Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue

A photoactive analogue of cisplatin was synthesized with two arylazopyrazole ligands, able to undergo trans–cis/cis–trans photoisomerizations. The cis photoisomer showed a dark half-life of 9 days. The cytotoxicities of both photoisomers of the complex were determined in several cancer and normal ce...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-11, Vol.67 (21), p.19103-19120
Hauptverfasser:	Stolarek, Marta, Kaminski, Kamil, Kaczor-Kamińska, Marta, Obłoza, Magdalena, Bonarek, Piotr, Czaja, Anna, Datta, Magdalena, Łach, Wojciech, Brela, Mateusz, Sikorski, Artur, Rak, Janusz, Nowakowska, Maria, Szczubiałka, Krzysztof
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Cisplatin - pharmacology DNA - chemistry DNA - metabolism Drug Screening Assays, Antitumor Glutathione - metabolism Humans Isomerism Light Mice Photochemical Processes Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - metabolism Pyrazoles - pharmacology Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism Stereoisomerism
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