Insights in AAV-mediated antigen-specific immunity and a strategy for AAV vaccine dose reduction through AAV-extracellular vesicle association

We previously showed therapeutic advantages of using a capsid-modified and encoded antigen-optimized AAV-based cancer vaccine to initiate strong antigen-specific immune responses and increase survival in a syngeneic mouse model of melanoma. In this study, we further explore AAV vaccine dose reductio...

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Veröffentlicht in:	Molecular therapy. Methods & clinical development 2024-12, Vol.32 (4), p.101358, Article 101358
Hauptverfasser:	Molina, Ester, Tejero, Marcos, Duzenli, Ozgun Firat, Kuoch, Hisae, Caine, Colin, Krotova, Karina, Paulaitis, Michael, Aslanidi, George
Format:	Artikel
Sprache:	eng
Schlagworte:	adeno-associated virus antigen-specific T cell cancer vaccine dendritic cell extracellular vesicles Original protective immune response
Online-Zugang:	Volltext
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