Novel insights into causal effects of serum lipids, lipid metabolites, and lipid-modifying targets on the risk of intracerebral aneurysm
Different serum lipid and lipid-lowering agents are reported to be related to the occurrence of intracerebral aneurysm (IA). However, the causal relationship between them requires further investigation. Mendelian randomization (MR) analysis was performed on IA and its subtypes by using instrumental...
Gespeichert in:
| Veröffentlicht in: | European stroke journal 2024-07, p.23969873241265019 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 23969873241265019 |
| container_title | European stroke journal |
| container_volume | |
| creator | Qiu, Youjia Song, Bingyi Yin, Ziqian Wang, Menghan Tao, Yuchen Xie, Minjia Duan, Aojie Chen, Zhouqing Si, Ke Wang, Zhong |
| description | Different serum lipid and lipid-lowering agents are reported to be related to the occurrence of intracerebral aneurysm (IA). However, the causal relationship between them requires further investigation.
Mendelian randomization (MR) analysis was performed on IA and its subtypes by using instrumental variants associated with six serum lipids, 249 lipid metabolic traits, and 10 lipid-lowering agents that were extracted from the largest genome-wide association study. Phenome-wide MR analyses were conducted to identify potential phenotypes associated with significant lipid-lowering agents.
After multiple comparison adjustments (
|
| doi_str_mv | 10.1177/23969873241265019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11569451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3086382672</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-f66364e5ed15cb53d25d08f1bb7da8300090cb1444d54cde6e5ea7adc4a683653</originalsourceid><addsrcrecordid>eNplUcFO3DAQtVArQJQP6AX52EMDnjh2nBOqELRIiF7as-XYk11DEi92grR_wGfjaGFV1NOMnt-8N-NHyFdg5wB1fVHyRjaq5mUFpRQMmgNyvGBFoxR82vc1PyKnKT0wlikguYJDcsQbpoBxcUxe7sMz9tSPya_WU8rNFKg1czI9xa5Dm7HQ0YRxHmjvN96l77tKB5xMG3o_YYbM6HZwMQTnu60fV3QycYXL_EinNdLo0-OilS2isRixjdnEjDjHbRq-kM-d6ROevtUT8vfm-s_Vr-Lu98_bqx93heWinIpOSi4rFOhA2FZwVwrHVAdtWzujeL6yYbaFqqqcqKxDmammNs5WRiouBT8hlzvdzdwO6Cwu2_R6E_1g4lYH4_XHl9Gv9So8awAhm0pAVvj2phDD04xp0oNPFvs-nxLmpDlT-ZtLWZeZCjuqjSGliN3eB5heUtT_pZhnzv5dcD_xnhl_BYLGmzg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3086382672</pqid></control><display><type>article</type><title>Novel insights into causal effects of serum lipids, lipid metabolites, and lipid-modifying targets on the risk of intracerebral aneurysm</title><source>SAGE Complete A-Z List</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Qiu, Youjia ; Song, Bingyi ; Yin, Ziqian ; Wang, Menghan ; Tao, Yuchen ; Xie, Minjia ; Duan, Aojie ; Chen, Zhouqing ; Si, Ke ; Wang, Zhong</creator><creatorcontrib>Qiu, Youjia ; Song, Bingyi ; Yin, Ziqian ; Wang, Menghan ; Tao, Yuchen ; Xie, Minjia ; Duan, Aojie ; Chen, Zhouqing ; Si, Ke ; Wang, Zhong</creatorcontrib><description>Different serum lipid and lipid-lowering agents are reported to be related to the occurrence of intracerebral aneurysm (IA). However, the causal relationship between them requires further investigation.
Mendelian randomization (MR) analysis was performed on IA and its subtypes by using instrumental variants associated with six serum lipids, 249 lipid metabolic traits, and 10 lipid-lowering agents that were extracted from the largest genome-wide association study. Phenome-wide MR analyses were conducted to identify potential phenotypes associated with significant lipid-lowering agents.
After multiple comparison adjustments (
< 0.0083), genetically proxied triglyceride (TG) (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.07-1.47,
= 0.005) and high-density lipoprotein cholesterol (HDL-C) levels (OR 0.93, 95% CI 0.89-0.98,
= 0.008) showed causal relationships with the risk of IA. Four lipid metabolic traits showed a causal relationship with the risk of IA (
< 0.0002). As confirmed by drug target MR, the causal relationship between the HMGCR target and IA, HMGCR target and subarachnoid hemorrhage (SAH), ANGPTL3 target and SAH, CETP target, and SAH remained statistically significant after multiple adjustments (
< 0.005). Additionally, phenome-wide MR did not identify other diseases linked to the significant lipid-lowering agent (
< 6.39 × 10
).
This study not only supports that serum lipids (TG and HDL-C) are associated with IA but also confirms the positive effect and absence of safety concerns of intervening
,
, and
targets in IA and its subtypes, opening new avenues for IA treatment.</description><identifier>ISSN: 2396-9873</identifier><identifier>ISSN: 2396-9881</identifier><identifier>EISSN: 2396-9881</identifier><identifier>DOI: 10.1177/23969873241265019</identifier><identifier>PMID: 39081035</identifier><language>eng</language><publisher>England: SAGE Publications</publisher><subject>Original</subject><ispartof>European stroke journal, 2024-07, p.23969873241265019</ispartof><rights>European Stroke Organisation 2024 2024 European Stroke Organisation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c352t-f66364e5ed15cb53d25d08f1bb7da8300090cb1444d54cde6e5ea7adc4a683653</cites><orcidid>0000-0002-7342-0845</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569451/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569451/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39081035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Youjia</creatorcontrib><creatorcontrib>Song, Bingyi</creatorcontrib><creatorcontrib>Yin, Ziqian</creatorcontrib><creatorcontrib>Wang, Menghan</creatorcontrib><creatorcontrib>Tao, Yuchen</creatorcontrib><creatorcontrib>Xie, Minjia</creatorcontrib><creatorcontrib>Duan, Aojie</creatorcontrib><creatorcontrib>Chen, Zhouqing</creatorcontrib><creatorcontrib>Si, Ke</creatorcontrib><creatorcontrib>Wang, Zhong</creatorcontrib><title>Novel insights into causal effects of serum lipids, lipid metabolites, and lipid-modifying targets on the risk of intracerebral aneurysm</title><title>European stroke journal</title><addtitle>Eur Stroke J</addtitle><description>Different serum lipid and lipid-lowering agents are reported to be related to the occurrence of intracerebral aneurysm (IA). However, the causal relationship between them requires further investigation.
Mendelian randomization (MR) analysis was performed on IA and its subtypes by using instrumental variants associated with six serum lipids, 249 lipid metabolic traits, and 10 lipid-lowering agents that were extracted from the largest genome-wide association study. Phenome-wide MR analyses were conducted to identify potential phenotypes associated with significant lipid-lowering agents.
After multiple comparison adjustments (
< 0.0083), genetically proxied triglyceride (TG) (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.07-1.47,
= 0.005) and high-density lipoprotein cholesterol (HDL-C) levels (OR 0.93, 95% CI 0.89-0.98,
= 0.008) showed causal relationships with the risk of IA. Four lipid metabolic traits showed a causal relationship with the risk of IA (
< 0.0002). As confirmed by drug target MR, the causal relationship between the HMGCR target and IA, HMGCR target and subarachnoid hemorrhage (SAH), ANGPTL3 target and SAH, CETP target, and SAH remained statistically significant after multiple adjustments (
< 0.005). Additionally, phenome-wide MR did not identify other diseases linked to the significant lipid-lowering agent (
< 6.39 × 10
).
This study not only supports that serum lipids (TG and HDL-C) are associated with IA but also confirms the positive effect and absence of safety concerns of intervening
,
, and
targets in IA and its subtypes, opening new avenues for IA treatment.</description><subject>Original</subject><issn>2396-9873</issn><issn>2396-9881</issn><issn>2396-9881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNplUcFO3DAQtVArQJQP6AX52EMDnjh2nBOqELRIiF7as-XYk11DEi92grR_wGfjaGFV1NOMnt-8N-NHyFdg5wB1fVHyRjaq5mUFpRQMmgNyvGBFoxR82vc1PyKnKT0wlikguYJDcsQbpoBxcUxe7sMz9tSPya_WU8rNFKg1czI9xa5Dm7HQ0YRxHmjvN96l77tKB5xMG3o_YYbM6HZwMQTnu60fV3QycYXL_EinNdLo0-OilS2isRixjdnEjDjHbRq-kM-d6ROevtUT8vfm-s_Vr-Lu98_bqx93heWinIpOSi4rFOhA2FZwVwrHVAdtWzujeL6yYbaFqqqcqKxDmammNs5WRiouBT8hlzvdzdwO6Cwu2_R6E_1g4lYH4_XHl9Gv9So8awAhm0pAVvj2phDD04xp0oNPFvs-nxLmpDlT-ZtLWZeZCjuqjSGliN3eB5heUtT_pZhnzv5dcD_xnhl_BYLGmzg</recordid><startdate>20240730</startdate><enddate>20240730</enddate><creator>Qiu, Youjia</creator><creator>Song, Bingyi</creator><creator>Yin, Ziqian</creator><creator>Wang, Menghan</creator><creator>Tao, Yuchen</creator><creator>Xie, Minjia</creator><creator>Duan, Aojie</creator><creator>Chen, Zhouqing</creator><creator>Si, Ke</creator><creator>Wang, Zhong</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7342-0845</orcidid></search><sort><creationdate>20240730</creationdate><title>Novel insights into causal effects of serum lipids, lipid metabolites, and lipid-modifying targets on the risk of intracerebral aneurysm</title><author>Qiu, Youjia ; Song, Bingyi ; Yin, Ziqian ; Wang, Menghan ; Tao, Yuchen ; Xie, Minjia ; Duan, Aojie ; Chen, Zhouqing ; Si, Ke ; Wang, Zhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-f66364e5ed15cb53d25d08f1bb7da8300090cb1444d54cde6e5ea7adc4a683653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Youjia</creatorcontrib><creatorcontrib>Song, Bingyi</creatorcontrib><creatorcontrib>Yin, Ziqian</creatorcontrib><creatorcontrib>Wang, Menghan</creatorcontrib><creatorcontrib>Tao, Yuchen</creatorcontrib><creatorcontrib>Xie, Minjia</creatorcontrib><creatorcontrib>Duan, Aojie</creatorcontrib><creatorcontrib>Chen, Zhouqing</creatorcontrib><creatorcontrib>Si, Ke</creatorcontrib><creatorcontrib>Wang, Zhong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European stroke journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Youjia</au><au>Song, Bingyi</au><au>Yin, Ziqian</au><au>Wang, Menghan</au><au>Tao, Yuchen</au><au>Xie, Minjia</au><au>Duan, Aojie</au><au>Chen, Zhouqing</au><au>Si, Ke</au><au>Wang, Zhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel insights into causal effects of serum lipids, lipid metabolites, and lipid-modifying targets on the risk of intracerebral aneurysm</atitle><jtitle>European stroke journal</jtitle><addtitle>Eur Stroke J</addtitle><date>2024-07-30</date><risdate>2024</risdate><spage>23969873241265019</spage><pages>23969873241265019-</pages><issn>2396-9873</issn><issn>2396-9881</issn><eissn>2396-9881</eissn><abstract>Different serum lipid and lipid-lowering agents are reported to be related to the occurrence of intracerebral aneurysm (IA). However, the causal relationship between them requires further investigation.
Mendelian randomization (MR) analysis was performed on IA and its subtypes by using instrumental variants associated with six serum lipids, 249 lipid metabolic traits, and 10 lipid-lowering agents that were extracted from the largest genome-wide association study. Phenome-wide MR analyses were conducted to identify potential phenotypes associated with significant lipid-lowering agents.
After multiple comparison adjustments (
< 0.0083), genetically proxied triglyceride (TG) (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.07-1.47,
= 0.005) and high-density lipoprotein cholesterol (HDL-C) levels (OR 0.93, 95% CI 0.89-0.98,
= 0.008) showed causal relationships with the risk of IA. Four lipid metabolic traits showed a causal relationship with the risk of IA (
< 0.0002). As confirmed by drug target MR, the causal relationship between the HMGCR target and IA, HMGCR target and subarachnoid hemorrhage (SAH), ANGPTL3 target and SAH, CETP target, and SAH remained statistically significant after multiple adjustments (
< 0.005). Additionally, phenome-wide MR did not identify other diseases linked to the significant lipid-lowering agent (
< 6.39 × 10
).
This study not only supports that serum lipids (TG and HDL-C) are associated with IA but also confirms the positive effect and absence of safety concerns of intervening
,
, and
targets in IA and its subtypes, opening new avenues for IA treatment.</abstract><cop>England</cop><pub>SAGE Publications</pub><pmid>39081035</pmid><doi>10.1177/23969873241265019</doi><orcidid>https://orcid.org/0000-0002-7342-0845</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2396-9873 |
| ispartof | European stroke journal, 2024-07, p.23969873241265019 |
| issn | 2396-9873 2396-9881 2396-9881 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11569451 |
| source | SAGE Complete A-Z List; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Original |
| title | Novel insights into causal effects of serum lipids, lipid metabolites, and lipid-modifying targets on the risk of intracerebral aneurysm |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T21%3A47%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20insights%20into%20causal%20effects%20of%20serum%20lipids,%20lipid%20metabolites,%20and%20lipid-modifying%20targets%20on%20the%20risk%20of%20intracerebral%20aneurysm&rft.jtitle=European%20stroke%20journal&rft.au=Qiu,%20Youjia&rft.date=2024-07-30&rft.spage=23969873241265019&rft.pages=23969873241265019-&rft.issn=2396-9873&rft.eissn=2396-9881&rft_id=info:doi/10.1177/23969873241265019&rft_dat=%3Cproquest_pubme%3E3086382672%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3086382672&rft_id=info:pmid/39081035&rfr_iscdi=true |