Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats
Age-related cognitive impairment is a prevalent issue in developed societies. Gamma oscil2lations at 40 Hz have been identified as a potential therapeutic approach for age-related cognitive decline and can be induced through various modalities, including auditory, visual, electrical, and magnetic st...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2025-02, Vol.26 (1), p.11, Article 11 |
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| creator | Liu, Mingsong Li, Lei Chen, Ruizhe Wang, Qilin Zeng, Tongfei Hu, Junhong Yan, Changzhi Xiao, Jing Xia, Xuewei |
| description | Age-related cognitive impairment is a prevalent issue in developed societies. Gamma oscil2lations at 40 Hz have been identified as a potential therapeutic approach for age-related cognitive decline and can be induced through various modalities, including auditory, visual, electrical, and magnetic stimulation. In this study, we investigated a novel modality of stimulation: whole-body vibration at 40 Hz. We examined the effects of 40 Hz vibration on cognitive performance and associated neuronal activity in the brains of aged male rats. Our findings revealed that only vibration at 40 Hz, rather than 20 Hz or 80 Hz, elicited cortical gamma oscillations in aged male rats. Additionally, following 8 weeks of prolonged treatment, the implementation of 40 Hz whole-body vibration significantly augmented the cognitive function of aged male rats as evidenced by behavioral assessments. Mechanistic studies demonstrated that these beneficial effects were attributed to the reduction of neuronal apoptosis in hippocampal CA1 through regulation of synaptic connections between astrocytes and neurons via 40 Hz gamma oscillations. Collectively, this suggests a promising intervention for age-related cognitive decline and identifies neuron-astrocyte synapses as potential therapeutic targets. |
| doi_str_mv | 10.1007/s10522-024-10154-2 |
| format | Article |
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Gamma oscil2lations at 40 Hz have been identified as a potential therapeutic approach for age-related cognitive decline and can be induced through various modalities, including auditory, visual, electrical, and magnetic stimulation. In this study, we investigated a novel modality of stimulation: whole-body vibration at 40 Hz. We examined the effects of 40 Hz vibration on cognitive performance and associated neuronal activity in the brains of aged male rats. Our findings revealed that only vibration at 40 Hz, rather than 20 Hz or 80 Hz, elicited cortical gamma oscillations in aged male rats. Additionally, following 8 weeks of prolonged treatment, the implementation of 40 Hz whole-body vibration significantly augmented the cognitive function of aged male rats as evidenced by behavioral assessments. Mechanistic studies demonstrated that these beneficial effects were attributed to the reduction of neuronal apoptosis in hippocampal CA1 through regulation of synaptic connections between astrocytes and neurons via 40 Hz gamma oscillations. Collectively, this suggests a promising intervention for age-related cognitive decline and identifies neuron-astrocyte synapses as potential therapeutic targets.</description><identifier>ISSN: 1389-5729</identifier><identifier>ISSN: 1573-6768</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-024-10154-2</identifier><identifier>PMID: 39546054</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Age ; Aging - physiology ; Animals ; Apoptosis ; Astrocytes ; Biomedical and Life Sciences ; Cell Biology ; Cognition - physiology ; Cognitive ability ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - therapy ; Developmental Biology ; Gamma Rhythm - physiology ; Geriatrics/Gerontology ; Hippocampus ; Hippocampus - physiopathology ; Life Sciences ; Magnetic fields ; Male ; Oscillations ; Rats ; Rats, Sprague-Dawley ; Research Article ; Sensory integration ; Synapses ; Synapses - physiology ; Therapeutic targets ; Vibration ; Visual stimuli</subject><ispartof>Biogerontology (Dordrecht), 2025-02, Vol.26 (1), p.11, Article 11</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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Gamma oscil2lations at 40 Hz have been identified as a potential therapeutic approach for age-related cognitive decline and can be induced through various modalities, including auditory, visual, electrical, and magnetic stimulation. In this study, we investigated a novel modality of stimulation: whole-body vibration at 40 Hz. We examined the effects of 40 Hz vibration on cognitive performance and associated neuronal activity in the brains of aged male rats. Our findings revealed that only vibration at 40 Hz, rather than 20 Hz or 80 Hz, elicited cortical gamma oscillations in aged male rats. Additionally, following 8 weeks of prolonged treatment, the implementation of 40 Hz whole-body vibration significantly augmented the cognitive function of aged male rats as evidenced by behavioral assessments. Mechanistic studies demonstrated that these beneficial effects were attributed to the reduction of neuronal apoptosis in hippocampal CA1 through regulation of synaptic connections between astrocytes and neurons via 40 Hz gamma oscillations. Collectively, this suggests a promising intervention for age-related cognitive decline and identifies neuron-astrocyte synapses as potential therapeutic targets.</description><subject>Age</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Astrocytes</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - therapy</subject><subject>Developmental Biology</subject><subject>Gamma Rhythm - physiology</subject><subject>Geriatrics/Gerontology</subject><subject>Hippocampus</subject><subject>Hippocampus - physiopathology</subject><subject>Life Sciences</subject><subject>Magnetic fields</subject><subject>Male</subject><subject>Oscillations</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Article</subject><subject>Sensory integration</subject><subject>Synapses</subject><subject>Synapses - physiology</subject><subject>Therapeutic targets</subject><subject>Vibration</subject><subject>Visual stimuli</subject><issn>1389-5729</issn><issn>1573-6768</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9Ustu1DAUjRCIlsIPsECW2LAx-BE78QqhClqkSmxALK07zk3iKomDnYw0_RoWfAlfVs9MKY8FKz_O495rn6J4ztlrzlj1JnGmhKBMlJQzrkoqHhSnXFWS6krXD_Ne1oaqSpiT4klK14xxLbR6XJxIo0rNVHla_PjahwHpJjQ7svWbCIsPE8HBO78kUrKf3y9viAtx8Q4G0sE4AgnJ-WE4MBOBqSEwZkHIWsznDmnEjGKTdd3kF79F4scZfBxxWsjSx7B2Pen9PAcHGRgIpCUGt1uQpN0Ec8o-fiIjDEiya3paPGphSPjsbj0rvnx4__n8kl59uvh4_u6KOqn0QqtWoGZlhZw1WpemMiJfKDBQg2yxbbUQjeDVplXAHBPcSNO6BhsAIxGYPCveHn3ndTNi43K7EQY7Rz9C3NkA3v6NTL63XdhazpWus2F2eHXnEMO3FdNiR58c5teaMKzJSi5qU9W12hd7-Q_1OqxxyvMdWHuaqDNLHFkuhpQitvfdcGb3KbDHFNicAntIgRVZ9OLPOe4lv749E-SRkDI0dRh_1_6P7S1JmcM9</recordid><startdate>20250201</startdate><enddate>20250201</enddate><creator>Liu, Mingsong</creator><creator>Li, Lei</creator><creator>Chen, Ruizhe</creator><creator>Wang, Qilin</creator><creator>Zeng, Tongfei</creator><creator>Hu, Junhong</creator><creator>Yan, Changzhi</creator><creator>Xiao, Jing</creator><creator>Xia, Xuewei</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20250201</creationdate><title>Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats</title><author>Liu, Mingsong ; Li, Lei ; Chen, Ruizhe ; Wang, Qilin ; Zeng, Tongfei ; Hu, Junhong ; Yan, Changzhi ; Xiao, Jing ; Xia, Xuewei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-7f2e6047e10d66497922e65a9a8a3feff622d217bf5a0c021939fcdedaa93ea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Age</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Astrocytes</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive Dysfunction - therapy</topic><topic>Developmental Biology</topic><topic>Gamma Rhythm - physiology</topic><topic>Geriatrics/Gerontology</topic><topic>Hippocampus</topic><topic>Hippocampus - physiopathology</topic><topic>Life Sciences</topic><topic>Magnetic fields</topic><topic>Male</topic><topic>Oscillations</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Research Article</topic><topic>Sensory integration</topic><topic>Synapses</topic><topic>Synapses - physiology</topic><topic>Therapeutic targets</topic><topic>Vibration</topic><topic>Visual stimuli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Mingsong</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><creatorcontrib>Chen, Ruizhe</creatorcontrib><creatorcontrib>Wang, Qilin</creatorcontrib><creatorcontrib>Zeng, Tongfei</creatorcontrib><creatorcontrib>Hu, Junhong</creatorcontrib><creatorcontrib>Yan, Changzhi</creatorcontrib><creatorcontrib>Xiao, Jing</creatorcontrib><creatorcontrib>Xia, Xuewei</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Mingsong</au><au>Li, Lei</au><au>Chen, Ruizhe</au><au>Wang, Qilin</au><au>Zeng, Tongfei</au><au>Hu, Junhong</au><au>Yan, Changzhi</au><au>Xiao, Jing</au><au>Xia, Xuewei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2025-02-01</date><risdate>2025</risdate><volume>26</volume><issue>1</issue><spage>11</spage><pages>11-</pages><artnum>11</artnum><issn>1389-5729</issn><issn>1573-6768</issn><eissn>1573-6768</eissn><abstract>Age-related cognitive impairment is a prevalent issue in developed societies. Gamma oscil2lations at 40 Hz have been identified as a potential therapeutic approach for age-related cognitive decline and can be induced through various modalities, including auditory, visual, electrical, and magnetic stimulation. In this study, we investigated a novel modality of stimulation: whole-body vibration at 40 Hz. We examined the effects of 40 Hz vibration on cognitive performance and associated neuronal activity in the brains of aged male rats. Our findings revealed that only vibration at 40 Hz, rather than 20 Hz or 80 Hz, elicited cortical gamma oscillations in aged male rats. Additionally, following 8 weeks of prolonged treatment, the implementation of 40 Hz whole-body vibration significantly augmented the cognitive function of aged male rats as evidenced by behavioral assessments. 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| subjects | Age Aging - physiology Animals Apoptosis Astrocytes Biomedical and Life Sciences Cell Biology Cognition - physiology Cognitive ability Cognitive Dysfunction - physiopathology Cognitive Dysfunction - therapy Developmental Biology Gamma Rhythm - physiology Geriatrics/Gerontology Hippocampus Hippocampus - physiopathology Life Sciences Magnetic fields Male Oscillations Rats Rats, Sprague-Dawley Research Article Sensory integration Synapses Synapses - physiology Therapeutic targets Vibration Visual stimuli |
| title | Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats |
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