Pathophysiological role of ion channels and transporters in hepatocellular carcinoma
The incidence of hepatocellular carcinoma (HCC) has continued to increase annually worldwide, and HCC has become a common cause of cancer-related death. Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge....
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| Veröffentlicht in: | Cancer gene therapy 2024-11, Vol.31 (11), p.1611-1618 |
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| creator | Zhang, Li Gu, Hong Li, Xin Wang, Yongfeng Yao, Shun Chen, Xingyue Zheng, Liming Yang, Xingyue Du, Qian An, Jiaxing Wen, Guorong Zhu, Jiaxing Jin, Hai Tuo, Biguang |
| description | The incidence of hepatocellular carcinoma (HCC) has continued to increase annually worldwide, and HCC has become a common cause of cancer-related death. Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed. |
| doi_str_mv | 10.1038/s41417-024-00782-8 |
| format | Article |
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Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed.</description><identifier>ISSN: 0929-1903</identifier><identifier>ISSN: 1476-5500</identifier><identifier>EISSN: 1476-5500</identifier><identifier>DOI: 10.1038/s41417-024-00782-8</identifier><identifier>PMID: 39048663</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>13/2 ; 38/35 ; 42/89 ; 631/67/1059/602 ; 692/699/67/1059/602 ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell adhesion & migration ; Electrolyte balance ; Gene Expression ; Gene Therapy ; Hepatocellular carcinoma ; Homeostasis ; Humans ; Ion channels ; Ion Channels - metabolism ; Liver cancer ; Liver diseases ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Membrane Transport Proteins - genetics ; Membrane Transport Proteins - metabolism ; Molecular modelling ; Pathophysiology ; Review ; Review Article ; Targeted cancer therapy ; Therapeutic targets</subject><ispartof>Cancer gene therapy, 2024-11, Vol.31 (11), p.1611-1618</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed.</description><subject>13/2</subject><subject>38/35</subject><subject>42/89</subject><subject>631/67/1059/602</subject><subject>692/699/67/1059/602</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell adhesion & migration</subject><subject>Electrolyte balance</subject><subject>Gene Expression</subject><subject>Gene Therapy</subject><subject>Hepatocellular carcinoma</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Ion channels</subject><subject>Ion Channels - metabolism</subject><subject>Liver cancer</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Membrane Transport Proteins - genetics</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Molecular modelling</subject><subject>Pathophysiology</subject><subject>Review</subject><subject>Review Article</subject><subject>Targeted cancer therapy</subject><subject>Therapeutic targets</subject><issn>0929-1903</issn><issn>1476-5500</issn><issn>1476-5500</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU9PHSEUxYmp0af2C7hoSLrpZurlzzCwMsa0tYlJXeia8BjmDYYHU5gx8dsXfVbbLrqC5Pzu4R4OQqcEPhNg8qxwwknXAOUNQCdpI_fQivBONG0L8A6tQFHVEAXsEB2Vcg9QxY4doEOmgEsh2Ard3ph5TNP4WHwKaeOtCTin4HAasE8R29HE6ELBJvZ4ziaWKeXZ5YJ9xKObzJysC2EJJmNrsvUxbc0J2h9MKO79y3mM7r5-ub28aq5_fPt-eXHdWNaKuXFcckGEsUL1VjghLTV2YBKIUFLY1oKgQCkZ-l7w3vSkleuhXtZO9UCsY8fofOc7Leut662LdcOgp-y3Jj_qZLz-W4l-1Jv0oAlpRacAqsOnF4ecfi6uzHrry1MgE11aimYg6392HfCKfvwHvU9LjjWfZoRKqUTXtpWiO8rmVEp2w-s2BPRTa3rXmq6t6efWtKxDH_7M8Tryu6YKsB1QqhQ3Lr-9_R_bXz9UpOA</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Zhang, Li</creator><creator>Gu, Hong</creator><creator>Li, Xin</creator><creator>Wang, Yongfeng</creator><creator>Yao, Shun</creator><creator>Chen, Xingyue</creator><creator>Zheng, Liming</creator><creator>Yang, Xingyue</creator><creator>Du, Qian</creator><creator>An, Jiaxing</creator><creator>Wen, Guorong</creator><creator>Zhu, Jiaxing</creator><creator>Jin, Hai</creator><creator>Tuo, Biguang</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2264-1699</orcidid><orcidid>https://orcid.org/0000-0003-3147-3487</orcidid><orcidid>https://orcid.org/0000-0002-5852-286X</orcidid></search><sort><creationdate>20241101</creationdate><title>Pathophysiological role of ion channels and transporters in hepatocellular carcinoma</title><author>Zhang, Li ; 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Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>39048663</pmid><doi>10.1038/s41417-024-00782-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2264-1699</orcidid><orcidid>https://orcid.org/0000-0003-3147-3487</orcidid><orcidid>https://orcid.org/0000-0002-5852-286X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 13/2 38/35 42/89 631/67/1059/602 692/699/67/1059/602 Animals Biomedical and Life Sciences Biomedicine Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Electrolyte balance Gene Expression Gene Therapy Hepatocellular carcinoma Homeostasis Humans Ion channels Ion Channels - metabolism Liver cancer Liver diseases Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Molecular modelling Pathophysiology Review Review Article Targeted cancer therapy Therapeutic targets |
| title | Pathophysiological role of ion channels and transporters in hepatocellular carcinoma |
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