Caspase-2 is a condensate-mediated deubiquitinase in protein quality control

Protein ubiquitination plays a critical role in protein quality control in response to cellular stress. The excessive accumulation of ubiquitinated conjugates can be detrimental to cells and is recognized as a hallmark of multiple neurodegenerative diseases. However, an in-depth understanding of how...

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Veröffentlicht in:	Nature cell biology 2024-11, Vol.26 (11), p.1943-1957
Hauptverfasser:	Ge, Yingwei, Zhou, Lijie, Fu, Yesheng, He, Lijuan, Chen, Yi, Li, Dingchang, Xie, Yuping, Yang, Jun, Wu, Haitao, Dai, Hongmiao, Peng, Zhiqiang, Zhang, Yong, Yi, Shaoqiong, Wu, Bo, Zhang, Xin, Zhang, Yangjun, Ying, Wantao, Cui, Chun-Ping, Liu, Cui Hua, Zhang, Lingqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14/19 42/109 631/45/474/1768 631/80/458/582 64/60 82/29 82/58 82/83 Accumulation Allosteric properties Animals Apoptosis Biomedical and Life Sciences Cancer Research Caspase 2 - genetics Caspase 2 - metabolism Caspase-2 Cell Biology Cellular stress response Condensates Conjugates Cysteine Endopeptidases Defects Deubiquitinating Enzymes - genetics Deubiquitinating Enzymes - metabolism Developmental Biology DNA-binding protein HEK293 Cells Homeostasis Humans Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Neurodegenerative diseases Overloading Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Proteasomes Protein deficiency Proteins Proteolysis Quality control Stem Cells Ubiquitin Ubiquitin - metabolism Ubiquitination
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