The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, underscoring the urgent need for in-depth biological research. The phenomenon of alternative RNA splicing dysregulation is a common hallmark in cancer, including PDAC, presenting new avenues for understanding and developing d...

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Veröffentlicht in:	Cancer gene therapy 2024-11, Vol.31 (11), p.1646-1657
Hauptverfasser:	Blázquez-Encinas, Ricardo, Alors-Pérez, Emilia, Moreno-Montilla, María Trinidad, García-Vioque, Víctor, Sánchez-Frías, Marina Esther, Mafficini, Andrea, López-Cánovas, Juan L., Bousquet, Corinne, Gahete, Manuel D., Lawlor, Rita T., Luque, Raúl M., Scarpa, Aldo, Arjona‐Sánchez, Álvaro, Pedraza-Arevalo, Sergio, Ibáñez-Costa, Alejandro, Castaño, Justo P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/89 38/39 38/91 45/41 45/77 45/90 631/337/505 631/67/1504/1713 64/60 Adenocarcinoma Alternative splicing Animals Biomedical and Life Sciences Biomedicine Cancer Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Behavior Cell Line, Tumor Cell Proliferation - genetics Cellular Biology DEAD-box RNA Helicases Eukaryotic Initiation Factor-4A - genetics Eukaryotic Initiation Factor-4A - metabolism Exons Female Gene Expression Gene Expression Regulation, Neoplastic Gene silencing Gene Therapy Homeostasis Humans Life Sciences Malignancy Medical diagnosis Mice Pancreas Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Ribonucleic acid RNA RNA Splicing RNA-mediated interference Tumor cell lines Tumors
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