Exploration of One-Pot, Tandem Sulfamoylation and aza-Michael Cyclization Reactions for the Syntheses of Oxathiazinane Dioxide Heterocycles

Exploration of One-Pot, Tandem Sulfamoylation and aza-Michael Cyclization Reactions for the Syntheses of Oxathiazinane Dioxide Heterocycles

We show the first examples of one-pot tandem sulfamoylation/aza-Michael reactions for the preparation of oxathiazinane dioxide heterocycles from linear alkenyl alcohol precursors. Our optimized protocols are tolerant of a variety of functional groups and provide products that are amenable for furthe...

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Veröffentlicht in:Journal of organic chemistry 2024-11, Vol.89 (22), p.16774-16778
Hauptverfasser: Nirpal, Appasaheb K., Joshi, Harshit, Kelley, Steven P., Sathyamoorthi, Shyam
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container_start_page 16774
container_title Journal of organic chemistry
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creator Nirpal, Appasaheb K.
Joshi, Harshit
Kelley, Steven P.
Sathyamoorthi, Shyam
description We show the first examples of one-pot tandem sulfamoylation/aza-Michael reactions for the preparation of oxathiazinane dioxide heterocycles from linear alkenyl alcohol precursors. Our optimized protocols are tolerant of a variety of functional groups and provide products that are amenable for further transformations. The reactions scale well, and no special precautions are required to exclude air or ambient moisture.
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title Exploration of One-Pot, Tandem Sulfamoylation and aza-Michael Cyclization Reactions for the Syntheses of Oxathiazinane Dioxide Heterocycles
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