Raised intracellular [Ca2+] abolishes excitation-contraction coupling in skeletal muscle fibres of rat and toad

1. Raising the intracellular [Ca2+] for 10 s at 23 degrees C abolished depolarization-induced force responses in mechanically skinned muscle fibres of toad and rat (half-maximal effect at 10 and 23 microM, respectively), without affecting the ability of caffeine or low [Mg2+] to open the ryanodine r...

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Veröffentlicht in:	The Journal of physiology 1995-12, Vol.489 (Pt 2), p.349-362
Hauptverfasser:	Lamb, G D, Junankar, P R, Stephenson, D G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibia Animals Bufonidae Caffeine - pharmacology Calcium - physiology Hydrogen-Ion Concentration Immunohistochemistry Microscopy, Confocal Microscopy, Electron Muscle Contraction - physiology Muscle Fibers, Skeletal - ultrastructure Muscle, Skeletal - physiology Rats
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