GABAergic and glutamatergic effects on behaviour in fetal sheep
1. Studies were carried out in unanaesthetized fetal sheep at 125-135 days gestation to investigate neurotransmitters involved in behavioural state. 2. Catheters and electrodes were chronically placed to record tracheal and arterial pressure, electrocortical activity (ECoG), nuchal muscle activity a...
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| Veröffentlicht in: | The Journal of physiology 1995-09, Vol.487 (Pt 3), p.677-684 |
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| creator | Bissonnette, J M Hohimer, A R Knopp, S J |
| description | 1. Studies were carried out in unanaesthetized fetal sheep at 125-135 days gestation to investigate neurotransmitters involved
in behavioural state. 2. Catheters and electrodes were chronically placed to record tracheal and arterial pressure, electrocortical
activity (ECoG), nuchal muscle activity and to instill drugs into the cerebrospinal fluid (CSF) of the fourth ventricle. 3.
Administration of the N-methyl-D-aspartate receptor antagonists DL-2-amino-5-phosphopentanoic acid (AP5) or (+)-5-methyl-10,11-dihydro-5H-dibenzol[a,d]cyclohepten-5,10-
iminemoleate (MK-801) increased the incidence of fetal behaviour characterized by low voltage ECoG, nuchal muscle activity
and an increase in mean arterial blood pressure from 4.1 +/- 6 to 60.6 +/- 6.2% (mean +/- S.E.M.) (AP5; P = 0.003) and from
7.6 +/- 3.6 to 50.8 +/- 7.0% (MK-801; P = 0.004; values are expressed as the percentage of each 60 min period in which the
state was present). 4. The incidence of fetal breathing during periods of low voltage (LV)-ECoG and nuchal muscle activity
was 83.1 +/- 5.6%. The incidence of fetal breathing during LV-ECoG associated with nuchal muscle atonia was 63.1 +/- 5.0%
before AP5 or MK-801 and 64.4 +/- 9.8% after instillation of these drugs. The amplitude of fetal breaths increased from 4.0
+/- 0.3 mmHg in low voltage ECoG periods to 6.7 +/- 0.8 mmHg (P = 0.006) during periods of low voltage with nuchal muscle
activity. There was no significant change in breath timing during these periods. |
| doi_str_mv | 10.1113/jphysiol.1995.sp020909 |
| format | Article |
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in behavioural state. 2. Catheters and electrodes were chronically placed to record tracheal and arterial pressure, electrocortical
activity (ECoG), nuchal muscle activity and to instill drugs into the cerebrospinal fluid (CSF) of the fourth ventricle. 3.
Administration of the N-methyl-D-aspartate receptor antagonists DL-2-amino-5-phosphopentanoic acid (AP5) or (+)-5-methyl-10,11-dihydro-5H-dibenzol[a,d]cyclohepten-5,10-
iminemoleate (MK-801) increased the incidence of fetal behaviour characterized by low voltage ECoG, nuchal muscle activity
and an increase in mean arterial blood pressure from 4.1 +/- 6 to 60.6 +/- 6.2% (mean +/- S.E.M.) (AP5; P = 0.003) and from
7.6 +/- 3.6 to 50.8 +/- 7.0% (MK-801; P = 0.004; values are expressed as the percentage of each 60 min period in which the
state was present). 4. The incidence of fetal breathing during periods of low voltage (LV)-ECoG and nuchal muscle activity
was 83.1 +/- 5.6%. The incidence of fetal breathing during LV-ECoG associated with nuchal muscle atonia was 63.1 +/- 5.0%
before AP5 or MK-801 and 64.4 +/- 9.8% after instillation of these drugs. The amplitude of fetal breaths increased from 4.0
+/- 0.3 mmHg in low voltage ECoG periods to 6.7 +/- 0.8 mmHg (P = 0.006) during periods of low voltage with nuchal muscle
activity. There was no significant change in breath timing during these periods.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1995.sp020909</identifier><identifier>PMID: 8544130</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Arousal - drug effects ; Arousal - physiology ; Behavior, Animal - physiology ; Blood Gas Analysis ; Blood Pressure - physiology ; Electroencephalography - drug effects ; Female ; Fetal Movement - physiology ; gamma-Aminobutyric Acid - metabolism ; gamma-Aminobutyric Acid - physiology ; Glutamates - physiology ; Heart Rate, Fetal - drug effects ; Heart Rate, Fetal - physiology ; Oxygen Consumption - physiology ; Pregnancy ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Respiratory Muscles - drug effects ; Respiratory Muscles - physiology ; Sheep</subject><ispartof>The Journal of physiology, 1995-09, Vol.487 (Pt 3), p.677-684</ispartof><rights>1995 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5037-7c2d170868a3be921e53b1dacd4eafad511cd4e568c2a2cdab821281ec9465743</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156654/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156654/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8544130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bissonnette, J M</creatorcontrib><creatorcontrib>Hohimer, A R</creatorcontrib><creatorcontrib>Knopp, S J</creatorcontrib><title>GABAergic and glutamatergic effects on behaviour in fetal sheep</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. Studies were carried out in unanaesthetized fetal sheep at 125-135 days gestation to investigate neurotransmitters involved
in behavioural state. 2. Catheters and electrodes were chronically placed to record tracheal and arterial pressure, electrocortical
activity (ECoG), nuchal muscle activity and to instill drugs into the cerebrospinal fluid (CSF) of the fourth ventricle. 3.
Administration of the N-methyl-D-aspartate receptor antagonists DL-2-amino-5-phosphopentanoic acid (AP5) or (+)-5-methyl-10,11-dihydro-5H-dibenzol[a,d]cyclohepten-5,10-
iminemoleate (MK-801) increased the incidence of fetal behaviour characterized by low voltage ECoG, nuchal muscle activity
and an increase in mean arterial blood pressure from 4.1 +/- 6 to 60.6 +/- 6.2% (mean +/- S.E.M.) (AP5; P = 0.003) and from
7.6 +/- 3.6 to 50.8 +/- 7.0% (MK-801; P = 0.004; values are expressed as the percentage of each 60 min period in which the
state was present). 4. The incidence of fetal breathing during periods of low voltage (LV)-ECoG and nuchal muscle activity
was 83.1 +/- 5.6%. The incidence of fetal breathing during LV-ECoG associated with nuchal muscle atonia was 63.1 +/- 5.0%
before AP5 or MK-801 and 64.4 +/- 9.8% after instillation of these drugs. The amplitude of fetal breaths increased from 4.0
+/- 0.3 mmHg in low voltage ECoG periods to 6.7 +/- 0.8 mmHg (P = 0.006) during periods of low voltage with nuchal muscle
activity. There was no significant change in breath timing during these periods.</description><subject>Animals</subject><subject>Arousal - drug effects</subject><subject>Arousal - physiology</subject><subject>Behavior, Animal - physiology</subject><subject>Blood Gas Analysis</subject><subject>Blood Pressure - physiology</subject><subject>Electroencephalography - drug effects</subject><subject>Female</subject><subject>Fetal Movement - physiology</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Glutamates - physiology</subject><subject>Heart Rate, Fetal - drug effects</subject><subject>Heart Rate, Fetal - physiology</subject><subject>Oxygen Consumption - physiology</subject><subject>Pregnancy</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Respiratory Muscles - drug effects</subject><subject>Respiratory Muscles - physiology</subject><subject>Sheep</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFP3DAQha2qFWyhP6FVTj1UytZjx3F8oVpQgVZI5QBny3EmG6NsHOwEtP--ibIgeuvJo3nvfWM9Qr4AXQMA__7QN_vofLsGpcQ69pRRRdU7soIsV6mUir8nK0oZS7kUcEw-xvhAKXCq1BE5KkSWTfOK_LjanG8wbJ1NTFcl23YczM4MywbrGu0QE98lJTbmyfkxJK5LahxMm8QGsT8lH2rTRvx0eE_I_eXPu4vr9ObP1a-LzU1qBeUylZZVIGmRF4aXqBig4CVUxlYZmtpUAmAeRV5YZpitTFkwYAWgVVkuZMZPyNnC7cdyh5XFbgim1X1wOxP22hun_1U61-itf9IAIs_FDPh6AAT_OGIc9M5Fi21rOvRj1FLKDCjQyZgvRht8jAHr1yNA9Vy9fqlez9Xrl-qn4Oe3X3yNHbqe9PNFf3Yt7v-Tqu9-386LrJA8l3KCfFsgjds2zy6gXmLRW4fDXk8-fTtormfzX4GCp84</recordid><startdate>19950915</startdate><enddate>19950915</enddate><creator>Bissonnette, J M</creator><creator>Hohimer, A R</creator><creator>Knopp, S J</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19950915</creationdate><title>GABAergic and glutamatergic effects on behaviour in fetal sheep</title><author>Bissonnette, J M ; Hohimer, A R ; Knopp, S J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5037-7c2d170868a3be921e53b1dacd4eafad511cd4e568c2a2cdab821281ec9465743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Arousal - drug effects</topic><topic>Arousal - physiology</topic><topic>Behavior, Animal - physiology</topic><topic>Blood Gas Analysis</topic><topic>Blood Pressure - physiology</topic><topic>Electroencephalography - drug effects</topic><topic>Female</topic><topic>Fetal Movement - physiology</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Glutamates - physiology</topic><topic>Heart Rate, Fetal - drug effects</topic><topic>Heart Rate, Fetal - physiology</topic><topic>Oxygen Consumption - physiology</topic><topic>Pregnancy</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Respiratory Muscles - drug effects</topic><topic>Respiratory Muscles - physiology</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bissonnette, J M</creatorcontrib><creatorcontrib>Hohimer, A R</creatorcontrib><creatorcontrib>Knopp, S J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bissonnette, J M</au><au>Hohimer, A R</au><au>Knopp, S J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GABAergic and glutamatergic effects on behaviour in fetal sheep</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1995-09-15</date><risdate>1995</risdate><volume>487</volume><issue>Pt 3</issue><spage>677</spage><epage>684</epage><pages>677-684</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. Studies were carried out in unanaesthetized fetal sheep at 125-135 days gestation to investigate neurotransmitters involved
in behavioural state. 2. Catheters and electrodes were chronically placed to record tracheal and arterial pressure, electrocortical
activity (ECoG), nuchal muscle activity and to instill drugs into the cerebrospinal fluid (CSF) of the fourth ventricle. 3.
Administration of the N-methyl-D-aspartate receptor antagonists DL-2-amino-5-phosphopentanoic acid (AP5) or (+)-5-methyl-10,11-dihydro-5H-dibenzol[a,d]cyclohepten-5,10-
iminemoleate (MK-801) increased the incidence of fetal behaviour characterized by low voltage ECoG, nuchal muscle activity
and an increase in mean arterial blood pressure from 4.1 +/- 6 to 60.6 +/- 6.2% (mean +/- S.E.M.) (AP5; P = 0.003) and from
7.6 +/- 3.6 to 50.8 +/- 7.0% (MK-801; P = 0.004; values are expressed as the percentage of each 60 min period in which the
state was present). 4. The incidence of fetal breathing during periods of low voltage (LV)-ECoG and nuchal muscle activity
was 83.1 +/- 5.6%. The incidence of fetal breathing during LV-ECoG associated with nuchal muscle atonia was 63.1 +/- 5.0%
before AP5 or MK-801 and 64.4 +/- 9.8% after instillation of these drugs. The amplitude of fetal breaths increased from 4.0
+/- 0.3 mmHg in low voltage ECoG periods to 6.7 +/- 0.8 mmHg (P = 0.006) during periods of low voltage with nuchal muscle
activity. There was no significant change in breath timing during these periods.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>8544130</pmid><doi>10.1113/jphysiol.1995.sp020909</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0022-3751 1469-7793 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Arousal - drug effects Arousal - physiology Behavior, Animal - physiology Blood Gas Analysis Blood Pressure - physiology Electroencephalography - drug effects Female Fetal Movement - physiology gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - physiology Glutamates - physiology Heart Rate, Fetal - drug effects Heart Rate, Fetal - physiology Oxygen Consumption - physiology Pregnancy Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Respiratory Muscles - drug effects Respiratory Muscles - physiology Sheep |
| title | GABAergic and glutamatergic effects on behaviour in fetal sheep |
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