Hepatitis B Virus and Hepatitis C Virus Affect Mitochondrial Function Through Different Metabolic Pathways, Explaining Virus-Specific Clinical Features of Chronic Hepatitis

Abstract Background Hepatitis C virus (HCV) and hepatitis B virus (HBV) cause chronic hepatitis with important clinical differences. HCV causes hepatic steatosis and insulin resistance, while HBV confers increased risk of liver cancer. We hypothesized these differences may be due to virus-specific e...

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Veröffentlicht in:	The Journal of infectious diseases 2024-11, Vol.230 (5), p.e1012-e1022
Hauptverfasser:	Selvamani, Sakthi Priya, Khan, Anis, Tay, Enoch S E, Garvey, Matthew, Ajoyan, Harout, Diefenbach, Eve, Gloss, Brian S, Tu, Thomas, George, Jacob, Douglas, Mark W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Cellular stress response Chronic infection Disease resistance Fatty liver Glycolysis Hepacivirus - physiology Hepatitis B Hepatitis B virus - physiology Hepatitis B, Chronic - complications Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - virology Hepatitis C Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - virology Hepatocytes Humans Infections Insulin resistance Kinases Lactic acid Lactic Acid - metabolism Lipid peroxidation Liver cancer Liver diseases Major Mass spectroscopy Membrane potential Membrane Potential, Mitochondrial Metabolic Networks and Pathways Metabolic pathways Mitochondria Mitochondria - metabolism Oxidation Oxidative phosphorylation Phosphorylation Polymerase chain reaction Pyruvic acid Pyruvic Acid - metabolism Steatosis Viruses
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