Mechanism of action of a K+ channel activator BRL 38227 on ATP-sensitive K+ channels in mouse skeletal muscle fibres

1. Investigations were made into the effects of BRL 38227, a potassium channel activator, on ATP-sensitive potassium channels (K+ATP channels) in single fibres dissociated from the flexor digitorum brevis muscle of C57BL/6J mice. 2. In cell-attached patches BRL 38227 (100 microM) caused activation o...

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Veröffentlicht in:	The Journal of physiology 1994-08, Vol.478 (Pt 3), p.523-532
Hauptverfasser:	Hussain, M, Wareham, A C, Head, S I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Benzopyrans - pharmacology Cromakalim Female Glyburide - pharmacology Male Mice Mice, Inbred C57BL Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Patch-Clamp Techniques Potassium Channels - drug effects Pyrroles - pharmacology
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