Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy
Background and Purpose This study was undertaken to compare the sensitivity and specificity of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for multifocal motor neuropathy (MMN) with those of the American Association of Electrodiagnos...
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| Veröffentlicht in: | European journal of neurology 2024-12, Vol.31 (12), p.e16444-n/a |
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| creator | Doneddu, Pietro Emiliano Gallo, Chiara Gentile, Luca Cocito, Dario Falzone, Yuri Di Stefano, Vincenzo Inghilleri, Maurizio Cosentino, Giuseppe Matà, Sabrina Mazzeo, Anna Filosto, Massimiliano Peci, Erdita Sorrenti, Benedetta Brighina, Filippo Moret, Federica Vegezzi, Elisa Sperti, Martina Risi, Barbara Nobile‐Orazio, Eduardo |
| description | Background and Purpose
This study was undertaken to compare the sensitivity and specificity of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for multifocal motor neuropathy (MMN) with those of the American Association of Electrodiagnostic Medicine (AAEM).
Methods
Sensitivity and specificity of the two sets of criteria were retrospectively evaluated in 53 patients with MMN and 280 controls with axonal peripheral neuropathy, inflammatory demyelinating polyneuropathy, or amyotrophic lateral sclerosis. Comparison of the utility of nerve conduction studies with different numbers of nerves examined was also assessed.
Results
The 2010 EFNS/PNS criteria had a sensitivity of 47% for definite MMN and 57% for probable/definite MMN, whereas the AAEM criteria had a sensitivity of 28% for definite MMN and 53% for probable/definite MMN. The sensitivity of the AAEM criteria was higher when utilizing area compared to amplitude reduction to define conduction block. Using supportive criteria, the sensitivity of the 2010 EFNS/PNS criteria for probable/definite MMN increased to 64%, and an additional 36% patients fulfilled the criteria (possible MMN). Specificity values for definite and probable/definite MMN were slightly higher with the AAEM criteria (100%) compared to the EFNS/PNS criteria (98.5% and 97%). Extended nerve conduction studies yielded slightly increased diagnostic sensitivity for both sets of criteria without significantly affecting specificity.
Conclusions
In our patient populations, the 2010 EFNS/PNS criteria demonstrated higher sensitivity but slightly lower specificity compared to the AAEM criteria. Extended nerve conduction studies are advised to achieve slightly higher sensitivity while maintaining very high specificity. |
| doi_str_mv | 10.1111/ene.16444 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11554852</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3101231907</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3344-27ff0b0b1f8293c60d4029b8ddc8b0335c170acc2ad944632ec190efd60461923</originalsourceid><addsrcrecordid>eNp1kk1vEzEQhlcIREvhwB9AlriUwzb-2o-cUBSlFKkUJOBseb2ziatde7G9Rfm9_BEmTRq1SPhia-bxO-_Yk2VvGb1guGbg4IKVUspn2SmTZZ0zIdhzPIuC5QWj7CR7FeMtpZRXnL7MTsSci1LQ6jT7s_TDqION3hHfkbQB0lq9dj4ma4g2ZgrabB9SnDJKVlPwI2hHLqGFoJPdX70BjPd-bY3uyXdvLCQLcfYNgh03yPVIhDs4pLZEu5YsBswalFrEiOGj1qoHk4J_5OQLtNZY98SdCTbhfU06H8gw9cl2fld88AkDbudn1GmzfZ296HQf4c1hP8t-Xq5-LK_y66-fPi8X17kRQsqcV11HG9qwruZzYUraSsrnTd22pm6oEIVhFcUX4bqdS1kKDobNKXRtSWXJ8EXPso973XFqBmgNuIRtqzHYQYet8tqqpxlnN2rt7xRjRSHrYqdwflAI_tcEManBRgN9rx34KSqBf8kFVq0Qff8Peuun4LA_pHhZc-xpR33YUyb4GAN0RzeMqt3sKJwddT87yL57bP9IPgwLArM98Nv2sP2_klrdrPaSfwGLGtOw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3126823347</pqid></control><display><type>article</type><title>Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>Wiley Online Library Journals Frontfile Complete</source><source>PubMed Central</source><creator>Doneddu, Pietro Emiliano ; Gallo, Chiara ; Gentile, Luca ; Cocito, Dario ; Falzone, Yuri ; Di Stefano, Vincenzo ; Inghilleri, Maurizio ; Cosentino, Giuseppe ; Matà, Sabrina ; Mazzeo, Anna ; Filosto, Massimiliano ; Peci, Erdita ; Sorrenti, Benedetta ; Brighina, Filippo ; Moret, Federica ; Vegezzi, Elisa ; Sperti, Martina ; Risi, Barbara ; Nobile‐Orazio, Eduardo</creator><creatorcontrib>Doneddu, Pietro Emiliano ; Gallo, Chiara ; Gentile, Luca ; Cocito, Dario ; Falzone, Yuri ; Di Stefano, Vincenzo ; Inghilleri, Maurizio ; Cosentino, Giuseppe ; Matà, Sabrina ; Mazzeo, Anna ; Filosto, Massimiliano ; Peci, Erdita ; Sorrenti, Benedetta ; Brighina, Filippo ; Moret, Federica ; Vegezzi, Elisa ; Sperti, Martina ; Risi, Barbara ; Nobile‐Orazio, Eduardo ; on the behalf of the Italian MMN Database Study Group</creatorcontrib><description>Background and Purpose
This study was undertaken to compare the sensitivity and specificity of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for multifocal motor neuropathy (MMN) with those of the American Association of Electrodiagnostic Medicine (AAEM).
Methods
Sensitivity and specificity of the two sets of criteria were retrospectively evaluated in 53 patients with MMN and 280 controls with axonal peripheral neuropathy, inflammatory demyelinating polyneuropathy, or amyotrophic lateral sclerosis. Comparison of the utility of nerve conduction studies with different numbers of nerves examined was also assessed.
Results
The 2010 EFNS/PNS criteria had a sensitivity of 47% for definite MMN and 57% for probable/definite MMN, whereas the AAEM criteria had a sensitivity of 28% for definite MMN and 53% for probable/definite MMN. The sensitivity of the AAEM criteria was higher when utilizing area compared to amplitude reduction to define conduction block. Using supportive criteria, the sensitivity of the 2010 EFNS/PNS criteria for probable/definite MMN increased to 64%, and an additional 36% patients fulfilled the criteria (possible MMN). Specificity values for definite and probable/definite MMN were slightly higher with the AAEM criteria (100%) compared to the EFNS/PNS criteria (98.5% and 97%). Extended nerve conduction studies yielded slightly increased diagnostic sensitivity for both sets of criteria without significantly affecting specificity.
Conclusions
In our patient populations, the 2010 EFNS/PNS criteria demonstrated higher sensitivity but slightly lower specificity compared to the AAEM criteria. Extended nerve conduction studies are advised to achieve slightly higher sensitivity while maintaining very high specificity.</description><identifier>ISSN: 1351-5101</identifier><identifier>ISSN: 1468-1331</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.16444</identifier><identifier>PMID: 39236307</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - diagnosis ; Amyotrophic Lateral Sclerosis - physiopathology ; Criteria ; Demyelination ; diagnosis ; diagnostic criteria ; Diagnostic systems ; Electrodiagnosis - methods ; Electrodiagnosis - standards ; Europe ; Female ; guidelines ; Humans ; Male ; Middle Aged ; MMN ; Motor Neuron Disease - diagnosis ; Motor Neuron Disease - physiopathology ; multifocal motor neuropathy ; Nerve conduction ; Neural Conduction - physiology ; Neuropathies ; Original ; Peripheral nerves ; Peripheral neuropathy ; Polyneuropathies - diagnosis ; Polyneuropathies - physiopathology ; Polyneuropathy ; Population studies ; Progressive motor neuropathy ; Retrospective Studies ; Sensitivity analysis ; Sensitivity and Specificity ; Societies, Medical - standards ; United States</subject><ispartof>European journal of neurology, 2024-12, Vol.31 (12), p.e16444-n/a</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3344-27ff0b0b1f8293c60d4029b8ddc8b0335c170acc2ad944632ec190efd60461923</cites><orcidid>0000-0001-8776-6831 ; 0000-0002-2852-7512 ; 0000-0002-6964-618X ; 0000-0003-2624-8138 ; 0000-0001-9805-1655</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554852/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554852/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39236307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doneddu, Pietro Emiliano</creatorcontrib><creatorcontrib>Gallo, Chiara</creatorcontrib><creatorcontrib>Gentile, Luca</creatorcontrib><creatorcontrib>Cocito, Dario</creatorcontrib><creatorcontrib>Falzone, Yuri</creatorcontrib><creatorcontrib>Di Stefano, Vincenzo</creatorcontrib><creatorcontrib>Inghilleri, Maurizio</creatorcontrib><creatorcontrib>Cosentino, Giuseppe</creatorcontrib><creatorcontrib>Matà, Sabrina</creatorcontrib><creatorcontrib>Mazzeo, Anna</creatorcontrib><creatorcontrib>Filosto, Massimiliano</creatorcontrib><creatorcontrib>Peci, Erdita</creatorcontrib><creatorcontrib>Sorrenti, Benedetta</creatorcontrib><creatorcontrib>Brighina, Filippo</creatorcontrib><creatorcontrib>Moret, Federica</creatorcontrib><creatorcontrib>Vegezzi, Elisa</creatorcontrib><creatorcontrib>Sperti, Martina</creatorcontrib><creatorcontrib>Risi, Barbara</creatorcontrib><creatorcontrib>Nobile‐Orazio, Eduardo</creatorcontrib><creatorcontrib>on the behalf of the Italian MMN Database Study Group</creatorcontrib><title>Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and Purpose
This study was undertaken to compare the sensitivity and specificity of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for multifocal motor neuropathy (MMN) with those of the American Association of Electrodiagnostic Medicine (AAEM).
Methods
Sensitivity and specificity of the two sets of criteria were retrospectively evaluated in 53 patients with MMN and 280 controls with axonal peripheral neuropathy, inflammatory demyelinating polyneuropathy, or amyotrophic lateral sclerosis. Comparison of the utility of nerve conduction studies with different numbers of nerves examined was also assessed.
Results
The 2010 EFNS/PNS criteria had a sensitivity of 47% for definite MMN and 57% for probable/definite MMN, whereas the AAEM criteria had a sensitivity of 28% for definite MMN and 53% for probable/definite MMN. The sensitivity of the AAEM criteria was higher when utilizing area compared to amplitude reduction to define conduction block. Using supportive criteria, the sensitivity of the 2010 EFNS/PNS criteria for probable/definite MMN increased to 64%, and an additional 36% patients fulfilled the criteria (possible MMN). Specificity values for definite and probable/definite MMN were slightly higher with the AAEM criteria (100%) compared to the EFNS/PNS criteria (98.5% and 97%). Extended nerve conduction studies yielded slightly increased diagnostic sensitivity for both sets of criteria without significantly affecting specificity.
Conclusions
In our patient populations, the 2010 EFNS/PNS criteria demonstrated higher sensitivity but slightly lower specificity compared to the AAEM criteria. Extended nerve conduction studies are advised to achieve slightly higher sensitivity while maintaining very high specificity.</description><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - diagnosis</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Criteria</subject><subject>Demyelination</subject><subject>diagnosis</subject><subject>diagnostic criteria</subject><subject>Diagnostic systems</subject><subject>Electrodiagnosis - methods</subject><subject>Electrodiagnosis - standards</subject><subject>Europe</subject><subject>Female</subject><subject>guidelines</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MMN</subject><subject>Motor Neuron Disease - diagnosis</subject><subject>Motor Neuron Disease - physiopathology</subject><subject>multifocal motor neuropathy</subject><subject>Nerve conduction</subject><subject>Neural Conduction - physiology</subject><subject>Neuropathies</subject><subject>Original</subject><subject>Peripheral nerves</subject><subject>Peripheral neuropathy</subject><subject>Polyneuropathies - diagnosis</subject><subject>Polyneuropathies - physiopathology</subject><subject>Polyneuropathy</subject><subject>Population studies</subject><subject>Progressive motor neuropathy</subject><subject>Retrospective Studies</subject><subject>Sensitivity analysis</subject><subject>Sensitivity and Specificity</subject><subject>Societies, Medical - standards</subject><subject>United States</subject><issn>1351-5101</issn><issn>1468-1331</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kk1vEzEQhlcIREvhwB9AlriUwzb-2o-cUBSlFKkUJOBseb2ziatde7G9Rfm9_BEmTRq1SPhia-bxO-_Yk2VvGb1guGbg4IKVUspn2SmTZZ0zIdhzPIuC5QWj7CR7FeMtpZRXnL7MTsSci1LQ6jT7s_TDqION3hHfkbQB0lq9dj4ma4g2ZgrabB9SnDJKVlPwI2hHLqGFoJPdX70BjPd-bY3uyXdvLCQLcfYNgh03yPVIhDs4pLZEu5YsBswalFrEiOGj1qoHk4J_5OQLtNZY98SdCTbhfU06H8gw9cl2fld88AkDbudn1GmzfZ296HQf4c1hP8t-Xq5-LK_y66-fPi8X17kRQsqcV11HG9qwruZzYUraSsrnTd22pm6oEIVhFcUX4bqdS1kKDobNKXRtSWXJ8EXPso973XFqBmgNuIRtqzHYQYet8tqqpxlnN2rt7xRjRSHrYqdwflAI_tcEManBRgN9rx34KSqBf8kFVq0Qff8Peuun4LA_pHhZc-xpR33YUyb4GAN0RzeMqt3sKJwddT87yL57bP9IPgwLArM98Nv2sP2_klrdrPaSfwGLGtOw</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Doneddu, Pietro Emiliano</creator><creator>Gallo, Chiara</creator><creator>Gentile, Luca</creator><creator>Cocito, Dario</creator><creator>Falzone, Yuri</creator><creator>Di Stefano, Vincenzo</creator><creator>Inghilleri, Maurizio</creator><creator>Cosentino, Giuseppe</creator><creator>Matà, Sabrina</creator><creator>Mazzeo, Anna</creator><creator>Filosto, Massimiliano</creator><creator>Peci, Erdita</creator><creator>Sorrenti, Benedetta</creator><creator>Brighina, Filippo</creator><creator>Moret, Federica</creator><creator>Vegezzi, Elisa</creator><creator>Sperti, Martina</creator><creator>Risi, Barbara</creator><creator>Nobile‐Orazio, Eduardo</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8776-6831</orcidid><orcidid>https://orcid.org/0000-0002-2852-7512</orcidid><orcidid>https://orcid.org/0000-0002-6964-618X</orcidid><orcidid>https://orcid.org/0000-0003-2624-8138</orcidid><orcidid>https://orcid.org/0000-0001-9805-1655</orcidid></search><sort><creationdate>202412</creationdate><title>Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy</title><author>Doneddu, Pietro Emiliano ; Gallo, Chiara ; Gentile, Luca ; Cocito, Dario ; Falzone, Yuri ; Di Stefano, Vincenzo ; Inghilleri, Maurizio ; Cosentino, Giuseppe ; Matà, Sabrina ; Mazzeo, Anna ; Filosto, Massimiliano ; Peci, Erdita ; Sorrenti, Benedetta ; Brighina, Filippo ; Moret, Federica ; Vegezzi, Elisa ; Sperti, Martina ; Risi, Barbara ; Nobile‐Orazio, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3344-27ff0b0b1f8293c60d4029b8ddc8b0335c170acc2ad944632ec190efd60461923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - diagnosis</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Criteria</topic><topic>Demyelination</topic><topic>diagnosis</topic><topic>diagnostic criteria</topic><topic>Diagnostic systems</topic><topic>Electrodiagnosis - methods</topic><topic>Electrodiagnosis - standards</topic><topic>Europe</topic><topic>Female</topic><topic>guidelines</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MMN</topic><topic>Motor Neuron Disease - diagnosis</topic><topic>Motor Neuron Disease - physiopathology</topic><topic>multifocal motor neuropathy</topic><topic>Nerve conduction</topic><topic>Neural Conduction - physiology</topic><topic>Neuropathies</topic><topic>Original</topic><topic>Peripheral nerves</topic><topic>Peripheral neuropathy</topic><topic>Polyneuropathies - diagnosis</topic><topic>Polyneuropathies - physiopathology</topic><topic>Polyneuropathy</topic><topic>Population studies</topic><topic>Progressive motor neuropathy</topic><topic>Retrospective Studies</topic><topic>Sensitivity analysis</topic><topic>Sensitivity and Specificity</topic><topic>Societies, Medical - standards</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doneddu, Pietro Emiliano</creatorcontrib><creatorcontrib>Gallo, Chiara</creatorcontrib><creatorcontrib>Gentile, Luca</creatorcontrib><creatorcontrib>Cocito, Dario</creatorcontrib><creatorcontrib>Falzone, Yuri</creatorcontrib><creatorcontrib>Di Stefano, Vincenzo</creatorcontrib><creatorcontrib>Inghilleri, Maurizio</creatorcontrib><creatorcontrib>Cosentino, Giuseppe</creatorcontrib><creatorcontrib>Matà, Sabrina</creatorcontrib><creatorcontrib>Mazzeo, Anna</creatorcontrib><creatorcontrib>Filosto, Massimiliano</creatorcontrib><creatorcontrib>Peci, Erdita</creatorcontrib><creatorcontrib>Sorrenti, Benedetta</creatorcontrib><creatorcontrib>Brighina, Filippo</creatorcontrib><creatorcontrib>Moret, Federica</creatorcontrib><creatorcontrib>Vegezzi, Elisa</creatorcontrib><creatorcontrib>Sperti, Martina</creatorcontrib><creatorcontrib>Risi, Barbara</creatorcontrib><creatorcontrib>Nobile‐Orazio, Eduardo</creatorcontrib><creatorcontrib>on the behalf of the Italian MMN Database Study Group</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doneddu, Pietro Emiliano</au><au>Gallo, Chiara</au><au>Gentile, Luca</au><au>Cocito, Dario</au><au>Falzone, Yuri</au><au>Di Stefano, Vincenzo</au><au>Inghilleri, Maurizio</au><au>Cosentino, Giuseppe</au><au>Matà, Sabrina</au><au>Mazzeo, Anna</au><au>Filosto, Massimiliano</au><au>Peci, Erdita</au><au>Sorrenti, Benedetta</au><au>Brighina, Filippo</au><au>Moret, Federica</au><au>Vegezzi, Elisa</au><au>Sperti, Martina</au><au>Risi, Barbara</au><au>Nobile‐Orazio, Eduardo</au><aucorp>on the behalf of the Italian MMN Database Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>31</volume><issue>12</issue><spage>e16444</spage><epage>n/a</epage><pages>e16444-n/a</pages><issn>1351-5101</issn><issn>1468-1331</issn><eissn>1468-1331</eissn><abstract>Background and Purpose
This study was undertaken to compare the sensitivity and specificity of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for multifocal motor neuropathy (MMN) with those of the American Association of Electrodiagnostic Medicine (AAEM).
Methods
Sensitivity and specificity of the two sets of criteria were retrospectively evaluated in 53 patients with MMN and 280 controls with axonal peripheral neuropathy, inflammatory demyelinating polyneuropathy, or amyotrophic lateral sclerosis. Comparison of the utility of nerve conduction studies with different numbers of nerves examined was also assessed.
Results
The 2010 EFNS/PNS criteria had a sensitivity of 47% for definite MMN and 57% for probable/definite MMN, whereas the AAEM criteria had a sensitivity of 28% for definite MMN and 53% for probable/definite MMN. The sensitivity of the AAEM criteria was higher when utilizing area compared to amplitude reduction to define conduction block. Using supportive criteria, the sensitivity of the 2010 EFNS/PNS criteria for probable/definite MMN increased to 64%, and an additional 36% patients fulfilled the criteria (possible MMN). Specificity values for definite and probable/definite MMN were slightly higher with the AAEM criteria (100%) compared to the EFNS/PNS criteria (98.5% and 97%). Extended nerve conduction studies yielded slightly increased diagnostic sensitivity for both sets of criteria without significantly affecting specificity.
Conclusions
In our patient populations, the 2010 EFNS/PNS criteria demonstrated higher sensitivity but slightly lower specificity compared to the AAEM criteria. Extended nerve conduction studies are advised to achieve slightly higher sensitivity while maintaining very high specificity.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>39236307</pmid><doi>10.1111/ene.16444</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8776-6831</orcidid><orcidid>https://orcid.org/0000-0002-2852-7512</orcidid><orcidid>https://orcid.org/0000-0002-6964-618X</orcidid><orcidid>https://orcid.org/0000-0003-2624-8138</orcidid><orcidid>https://orcid.org/0000-0001-9805-1655</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-5101 |
| ispartof | European journal of neurology, 2024-12, Vol.31 (12), p.e16444-n/a |
| issn | 1351-5101 1468-1331 1468-1331 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11554852 |
| source | MEDLINE; Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete; PubMed Central |
| subjects | Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - physiopathology Criteria Demyelination diagnosis diagnostic criteria Diagnostic systems Electrodiagnosis - methods Electrodiagnosis - standards Europe Female guidelines Humans Male Middle Aged MMN Motor Neuron Disease - diagnosis Motor Neuron Disease - physiopathology multifocal motor neuropathy Nerve conduction Neural Conduction - physiology Neuropathies Original Peripheral nerves Peripheral neuropathy Polyneuropathies - diagnosis Polyneuropathies - physiopathology Polyneuropathy Population studies Progressive motor neuropathy Retrospective Studies Sensitivity analysis Sensitivity and Specificity Societies, Medical - standards United States |
| title | Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T21%3A48%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20the%20diagnostic%20accuracy%20of%20the%202010%20European%20Federation%20of%20Neurological%20Societies/Peripheral%20Nerve%20Society%20and%20American%20Association%20of%20Electrodiagnostic%20Medicine%20diagnostic%20criteria%20for%20multifocal%20motor%20neuropathy&rft.jtitle=European%20journal%20of%20neurology&rft.au=Doneddu,%20Pietro%20Emiliano&rft.aucorp=on%20the%20behalf%20of%20the%20Italian%20MMN%20Database%20Study%20Group&rft.date=2024-12&rft.volume=31&rft.issue=12&rft.spage=e16444&rft.epage=n/a&rft.pages=e16444-n/a&rft.issn=1351-5101&rft.eissn=1468-1331&rft_id=info:doi/10.1111/ene.16444&rft_dat=%3Cproquest_pubme%3E3101231907%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3126823347&rft_id=info:pmid/39236307&rfr_iscdi=true |