Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia
Background and Purpose This study evaluated associations of brain amyloid with 2‐year objective and subjective cognitive measures in a trial‐ready older general population at risk for dementia. Methods Forty‐eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairme...
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| Veröffentlicht in: | European journal of neurology 2024-12, Vol.31 (12), p.e16436-n/a |
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| container_title | European journal of neurology |
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| creator | Saadmaan, Gazi Hall, Anette Ngandu, Tiia Kemppainen, Nina Mangialasche, Francesca Wittenberg, Gayle M. Matton, Anna Rinne, Juha O. Kivipelto, Miia Solomon, Alina |
| description | Background and Purpose
This study evaluated associations of brain amyloid with 2‐year objective and subjective cognitive measures in a trial‐ready older general population at risk for dementia.
Methods
Forty‐eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent 11C‐Pittsburgh compound B (PiB) positron emission tomography (PET) scans and assessment of cognition (modified Neuropsychological Test Battery [NTB]) and subjective memory complaints (Prospective and Retrospective Memory Questionnaire).
Results
Mean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB‐PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable 2‐year NTB total score and memory trajectories, but not with other objective or subjective cognitive measures. Overall, there was little cognitive decline during 2 years.
Conclusions
Amyloid accumulation may affect objective but not necessarily subjective cognition from a very early at‐risk stage, although substantial decline likely requires >2 years to occur. |
| doi_str_mv | 10.1111/ene.16436 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11554848</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3092009522</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3346-685d9c7277d15bb56d6f168ef2acd5036bf5d039ab134bbd62134166085dadfe3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi1ERUvhwAsgS1xAalqPHTvJqYJqoZUquMDZcuJJ8ZLEi50s2rdn2i0VIHUuM9Z883tGP2OvQJwCxRlOeAqmVOYJO4LS1AUoBU-pVhoKDQIO2fOc10IIWUnxjB2qBpRsquqIbT8kFybuxt0Qg-dDdP6E56VdYzeHLfIRx5h2vIvjZiBwzifcTZ7eN1O4A-bkbtmYAmZOSnHwmKjwYRv84obM3cxTyD94HxP3OOI0B_eCHfTUw5f3-Zh9-7j6enFZXH_5dHXx_rrolCpNYWrtm66SVeVBt6023vRgauyl67wWyrS99kI1rgVVtq03kjIYI2jO-R7VMTvf626WdkTf0efJDXaTwujSzkYX7L-dKXy3N3FrAbQu67Imhbf3Cin-XDDPdgy5w2FwE8YlWyUaKUSjpST0zX_oOi5povusAmlqSTcJot7tqS7FnBP2D9uAsLd2WrLT3tlJ7Ou_138g__hHwNke-BUG3D2uZFefV3vJ36iKq58</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3126823340</pqid></control><display><type>article</type><title>Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Wiley Open Access Journals</source><source>PubMed Central</source><creator>Saadmaan, Gazi ; Hall, Anette ; Ngandu, Tiia ; Kemppainen, Nina ; Mangialasche, Francesca ; Wittenberg, Gayle M. ; Matton, Anna ; Rinne, Juha O. ; Kivipelto, Miia ; Solomon, Alina</creator><creatorcontrib>Saadmaan, Gazi ; Hall, Anette ; Ngandu, Tiia ; Kemppainen, Nina ; Mangialasche, Francesca ; Wittenberg, Gayle M. ; Matton, Anna ; Rinne, Juha O. ; Kivipelto, Miia ; Solomon, Alina</creatorcontrib><description>Background and Purpose
This study evaluated associations of brain amyloid with 2‐year objective and subjective cognitive measures in a trial‐ready older general population at risk for dementia.
Methods
Forty‐eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent 11C‐Pittsburgh compound B (PiB) positron emission tomography (PET) scans and assessment of cognition (modified Neuropsychological Test Battery [NTB]) and subjective memory complaints (Prospective and Retrospective Memory Questionnaire).
Results
Mean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB‐PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable 2‐year NTB total score and memory trajectories, but not with other objective or subjective cognitive measures. Overall, there was little cognitive decline during 2 years.
Conclusions
Amyloid accumulation may affect objective but not necessarily subjective cognition from a very early at‐risk stage, although substantial decline likely requires >2 years to occur.</description><identifier>ISSN: 1351-5101</identifier><identifier>ISSN: 1468-1331</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.16436</identifier><identifier>PMID: 39132977</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer disease ; amyloid ; Aniline Compounds ; Brain ; Brain - diagnostic imaging ; Brain - metabolism ; clinical trial ; Cognition ; Cognitive ability ; Dementia - diagnostic imaging ; Dementia - epidemiology ; Dementia - metabolism ; Dementia and Cognitive Disorders ; Dementia disorders ; Executive function ; Female ; Humans ; Male ; Memory ; Memory Disorders - diagnostic imaging ; Memory Disorders - metabolism ; Neuropsychological Tests ; PiB‐PET ; Population studies ; Positron emission ; Positron emission tomography ; Risk ; Short Communication ; Thiazoles</subject><ispartof>European journal of neurology, 2024-12, Vol.31 (12), p.e16436-n/a</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3346-685d9c7277d15bb56d6f168ef2acd5036bf5d039ab134bbd62134166085dadfe3</cites><orcidid>0000-0002-0925-7609</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554848/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554848/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11543,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39132977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saadmaan, Gazi</creatorcontrib><creatorcontrib>Hall, Anette</creatorcontrib><creatorcontrib>Ngandu, Tiia</creatorcontrib><creatorcontrib>Kemppainen, Nina</creatorcontrib><creatorcontrib>Mangialasche, Francesca</creatorcontrib><creatorcontrib>Wittenberg, Gayle M.</creatorcontrib><creatorcontrib>Matton, Anna</creatorcontrib><creatorcontrib>Rinne, Juha O.</creatorcontrib><creatorcontrib>Kivipelto, Miia</creatorcontrib><creatorcontrib>Solomon, Alina</creatorcontrib><title>Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and Purpose
This study evaluated associations of brain amyloid with 2‐year objective and subjective cognitive measures in a trial‐ready older general population at risk for dementia.
Methods
Forty‐eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent 11C‐Pittsburgh compound B (PiB) positron emission tomography (PET) scans and assessment of cognition (modified Neuropsychological Test Battery [NTB]) and subjective memory complaints (Prospective and Retrospective Memory Questionnaire).
Results
Mean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB‐PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable 2‐year NTB total score and memory trajectories, but not with other objective or subjective cognitive measures. Overall, there was little cognitive decline during 2 years.
Conclusions
Amyloid accumulation may affect objective but not necessarily subjective cognition from a very early at‐risk stage, although substantial decline likely requires >2 years to occur.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer disease</subject><subject>amyloid</subject><subject>Aniline Compounds</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>clinical trial</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Dementia - diagnostic imaging</subject><subject>Dementia - epidemiology</subject><subject>Dementia - metabolism</subject><subject>Dementia and Cognitive Disorders</subject><subject>Dementia disorders</subject><subject>Executive function</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Disorders - diagnostic imaging</subject><subject>Memory Disorders - metabolism</subject><subject>Neuropsychological Tests</subject><subject>PiB‐PET</subject><subject>Population studies</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Risk</subject><subject>Short Communication</subject><subject>Thiazoles</subject><issn>1351-5101</issn><issn>1468-1331</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi1ERUvhwAsgS1xAalqPHTvJqYJqoZUquMDZcuJJ8ZLEi50s2rdn2i0VIHUuM9Z883tGP2OvQJwCxRlOeAqmVOYJO4LS1AUoBU-pVhoKDQIO2fOc10IIWUnxjB2qBpRsquqIbT8kFybuxt0Qg-dDdP6E56VdYzeHLfIRx5h2vIvjZiBwzifcTZ7eN1O4A-bkbtmYAmZOSnHwmKjwYRv84obM3cxTyD94HxP3OOI0B_eCHfTUw5f3-Zh9-7j6enFZXH_5dHXx_rrolCpNYWrtm66SVeVBt6023vRgauyl67wWyrS99kI1rgVVtq03kjIYI2jO-R7VMTvf626WdkTf0efJDXaTwujSzkYX7L-dKXy3N3FrAbQu67Imhbf3Cin-XDDPdgy5w2FwE8YlWyUaKUSjpST0zX_oOi5povusAmlqSTcJot7tqS7FnBP2D9uAsLd2WrLT3tlJ7Ou_138g__hHwNke-BUG3D2uZFefV3vJ36iKq58</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Saadmaan, Gazi</creator><creator>Hall, Anette</creator><creator>Ngandu, Tiia</creator><creator>Kemppainen, Nina</creator><creator>Mangialasche, Francesca</creator><creator>Wittenberg, Gayle M.</creator><creator>Matton, Anna</creator><creator>Rinne, Juha O.</creator><creator>Kivipelto, Miia</creator><creator>Solomon, Alina</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0925-7609</orcidid></search><sort><creationdate>202412</creationdate><title>Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia</title><author>Saadmaan, Gazi ; Hall, Anette ; Ngandu, Tiia ; Kemppainen, Nina ; Mangialasche, Francesca ; Wittenberg, Gayle M. ; Matton, Anna ; Rinne, Juha O. ; Kivipelto, Miia ; Solomon, Alina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3346-685d9c7277d15bb56d6f168ef2acd5036bf5d039ab134bbd62134166085dadfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer disease</topic><topic>amyloid</topic><topic>Aniline Compounds</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>clinical trial</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Dementia - diagnostic imaging</topic><topic>Dementia - epidemiology</topic><topic>Dementia - metabolism</topic><topic>Dementia and Cognitive Disorders</topic><topic>Dementia disorders</topic><topic>Executive function</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Disorders - diagnostic imaging</topic><topic>Memory Disorders - metabolism</topic><topic>Neuropsychological Tests</topic><topic>PiB‐PET</topic><topic>Population studies</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Risk</topic><topic>Short Communication</topic><topic>Thiazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saadmaan, Gazi</creatorcontrib><creatorcontrib>Hall, Anette</creatorcontrib><creatorcontrib>Ngandu, Tiia</creatorcontrib><creatorcontrib>Kemppainen, Nina</creatorcontrib><creatorcontrib>Mangialasche, Francesca</creatorcontrib><creatorcontrib>Wittenberg, Gayle M.</creatorcontrib><creatorcontrib>Matton, Anna</creatorcontrib><creatorcontrib>Rinne, Juha O.</creatorcontrib><creatorcontrib>Kivipelto, Miia</creatorcontrib><creatorcontrib>Solomon, Alina</creatorcontrib><collection>Wiley Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saadmaan, Gazi</au><au>Hall, Anette</au><au>Ngandu, Tiia</au><au>Kemppainen, Nina</au><au>Mangialasche, Francesca</au><au>Wittenberg, Gayle M.</au><au>Matton, Anna</au><au>Rinne, Juha O.</au><au>Kivipelto, Miia</au><au>Solomon, Alina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>31</volume><issue>12</issue><spage>e16436</spage><epage>n/a</epage><pages>e16436-n/a</pages><issn>1351-5101</issn><issn>1468-1331</issn><eissn>1468-1331</eissn><abstract>Background and Purpose
This study evaluated associations of brain amyloid with 2‐year objective and subjective cognitive measures in a trial‐ready older general population at risk for dementia.
Methods
Forty‐eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent 11C‐Pittsburgh compound B (PiB) positron emission tomography (PET) scans and assessment of cognition (modified Neuropsychological Test Battery [NTB]) and subjective memory complaints (Prospective and Retrospective Memory Questionnaire).
Results
Mean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB‐PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable 2‐year NTB total score and memory trajectories, but not with other objective or subjective cognitive measures. Overall, there was little cognitive decline during 2 years.
Conclusions
Amyloid accumulation may affect objective but not necessarily subjective cognition from a very early at‐risk stage, although substantial decline likely requires >2 years to occur.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>39132977</pmid><doi>10.1111/ene.16436</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0925-7609</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Open Access Journals; PubMed Central |
| subjects | Aged Aged, 80 and over Alzheimer disease amyloid Aniline Compounds Brain Brain - diagnostic imaging Brain - metabolism clinical trial Cognition Cognitive ability Dementia - diagnostic imaging Dementia - epidemiology Dementia - metabolism Dementia and Cognitive Disorders Dementia disorders Executive function Female Humans Male Memory Memory Disorders - diagnostic imaging Memory Disorders - metabolism Neuropsychological Tests PiB‐PET Population studies Positron emission Positron emission tomography Risk Short Communication Thiazoles |
| title | Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia |
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