Predominant CD8+ cell infiltration and low accumulation of regulatory T cells in immune checkpoint inhibitor‐induced tubulointerstitial nephritis

Immune checkpoint inhibitors (ICIs) can provide survival benefits to cancer patients; however, they sometimes result in the development of renal immune‐related adverse events (irAEs). Tubulointerstitial nephritis (TIN) is the most representative pathological feature of renal irAEs. However, the clin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pathology international 2024-06, Vol.74 (6), p.317-326
Hauptverfasser:	Tominaga, Kenta, Toda, Etsuko, Takeuchi, Kazuhiro, Takakuma, Shoichiro, Sakamoto, Emi, Kuno, Hideaki, Kajimoto, Yusuke, Terasaki, Yasuhiro, Kunugi, Shinobu, Mii, Akiko, Sakai, Yukinao, Terasaki, Mika, Shimizu, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adult Aged Aged, 80 and over CD25 antigen CD3 antigen CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Eosinophils Female Foxp3 protein Humans immune checkpoint inhibitor Immune checkpoint inhibitors Immune Checkpoint Inhibitors - adverse effects Immunoregulation Infiltration Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lymphocytes Lymphocytes B Lymphocytes T Macrophages Male Middle Aged Nephritis Nephritis, Interstitial - chemically induced Nephritis, Interstitial - immunology Nephritis, Interstitial - pathology Original Pathogenesis Plasma cells regulatory T cells Renal function T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology tubulointerstitial nephritis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!