Phylogenomic instructed target analysis reveals ELAV complex binding to multiple optimally spaced U-rich motifs

ELAV/Hu RNA-binding proteins are gene-specific regulators of alternative pre-mRNA processing. ELAV/Hu family proteins bind to short AU-rich motifs which are abundant in pre-mRNA, making it unclear how they achieve gene specificity. ELAV/Hu proteins multimerize, but how multimerization contributes to...

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Veröffentlicht in:	Nucleic acids research 2024-11, Vol.52 (20), p.12712-12726
Hauptverfasser:	McQuarrie, David W J, Soller, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - metabolism Binding Sites Humans Nucleic Acid Conformation Nucleotide Motifs Phylogeny Poly A - metabolism Protein Binding RNA and RNA-protein complexes RNA Precursors - chemistry RNA Precursors - genetics RNA Precursors - metabolism RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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