Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells

Vascular calcification is a complication that is frequently encountered in patients affected by atherosclerosis, diabetes, and chronic kidney disease (CKD), and that is characterized by the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). At present, there remains a pressing...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2024-12, Vol.81 (1), p.448, Article 448
Hauptverfasser:	Li, Long, Liu, Huimin, Chai, Quanyou, Wei, Junyi, Qin, Yuqiao, Yang, Jingyao, Liu, He, Qi, Jia, Guo, Chunling, Lu, Zhaoyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis Atherosclerosis Attenuation Benzhydryl Compounds - pharmacology Biochemistry Biomedical and Life Sciences Biomedicine Calcification Calcification (ectopic) Cardiovascular diseases Cell Biology Cell Transdifferentiation - drug effects Cells, Cultured Cobalt Cobalt chloride Deacetylation Diabetes mellitus Dietary restrictions Glucose Glucose - metabolism Glucose transporter Glucosides - pharmacology Humans Hypoxia Hypoxia-inducible factor 1a In vivo methods and tests Inhibitors Kidney diseases Life Sciences Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscles Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Nicotinamide adenine dinucleotide Original Original Article Osteogenesis - drug effects Proteasome inhibitors Proteasomes Signal Transduction - drug effects siRNA SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Smooth muscle Sodium-glucose cotransporter Sodium-Glucose Transporter 2 - genetics Sodium-Glucose Transporter 2 - metabolism Sodium-Glucose Transporter 2 Inhibitors - pharmacology Vascular Calcification - drug therapy Vascular Calcification - metabolism Vascular Calcification - pathology
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