Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics
Study design Cross-sectional cohort study. Objectives To examine: (1) the self-reported frequency of specific prescription benzodiazepine use, (2) concurrent benzodiazepine and opioid use, and (3) sociodemographic, SCI, and opioid use factors associated with frequent benzodiazepine use. Setting Comm...
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| Veröffentlicht in: | Spinal cord 2024-11, Vol.62 (11), p.667-673 |
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| creator | DiPiro, Nicole D. Dismuke-Greer, Clara E. Krause, James S. |
| description | Study design
Cross-sectional cohort study.
Objectives
To examine: (1) the self-reported frequency of specific prescription benzodiazepine use, (2) concurrent benzodiazepine and opioid use, and (3) sociodemographic, SCI, and opioid use factors associated with frequent benzodiazepine use.
Setting
Community.
Methods
Participants included 918 community dwelling adults with chronic ( > 1 year) traumatic SCI originally identified from a specialty hospital or a state-based surveillance system. Self-reported frequency of specific prescription benzodiazepines and opioids used, concurrent use, and factors associated with use were assessed.
Results
Twenty percent reported any benzodiazepine use in the past year and 13% reported at least weekly use. Concurrent daily or weekly use of benzodiazepines and opioids was reported by 6.5%, with those individuals taking an average of 1.1 (0.4) benzodiazepines and 1.4 (0.6) opioids. Compared to younger adults, those 50–65 years old had lower odds of at least weekly benzodiazepine use (OR = 0.50, 95% CI, 0.29–0.89,
p
-value = 0.02). Non-Hispanic Blacks reported lower use of benzodiazepines compared to non-Hispanic whites (OR = 0.32, 95% CI, 0.15–0.68,
p
-value = |
| doi_str_mv | 10.1038/s41393-024-01030-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549035</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3126244527</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-8f252e9867820960a2051e506cb0f463ee2febfc4d7e7827caf662a02537c33e3</originalsourceid><addsrcrecordid>eNp9kstu1TAQhiMEoqXwAiyQJTYsGvA9CZuqqspFqsSidG3NcSYnPsqxg-2A2mfiIev2HMplwWoszzf_jD1_Vb1k9C2jon2XJBOdqCmXNS0XtJaPqkMmG10rzeXjchaa17IwB9WzlDaU0o517dPqQHS8YU3XHFY_L3Ea6ohziBl7skJ_E3oHNzg7j2RJSGAb_JpAv0w5kR8uj8SOMXhnSSoMTMSG2BPnN0u8LoHkEUkKSwmQMkZPri5P3xNIKVgH2QW_V-lxG9YR5tHZ4335MQHfkzC74Pr73naECLaouJSdTc-rJwNMCV_s41F19eH869mn-uLLx89npxe1FUrnuh244ti1umk57TQFThVDRbVd0UFqgcgHXA1W9g0WpLEwaM2BciUaKwSKo-pkpzsvqy32Fn2OMJk5ui3EaxPAmb8z3o1mHb4bxpTsqFBF4c1eIYZvC6Zsti5ZnCbwGJZkBKNSiZaptqCv_0E3YYnlY-8oXhYpFW8KxXeUjSGliMPDNIyaOzeYnRtMcYO5d4ORpejVn-94KPm1_gKIHZBKyq8x_u79H9lbtZXEiw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3126244527</pqid></control><display><type>article</type><title>Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>DiPiro, Nicole D. ; Dismuke-Greer, Clara E. ; Krause, James S.</creator><creatorcontrib>DiPiro, Nicole D. ; Dismuke-Greer, Clara E. ; Krause, James S.</creatorcontrib><description>Study design
Cross-sectional cohort study.
Objectives
To examine: (1) the self-reported frequency of specific prescription benzodiazepine use, (2) concurrent benzodiazepine and opioid use, and (3) sociodemographic, SCI, and opioid use factors associated with frequent benzodiazepine use.
Setting
Community.
Methods
Participants included 918 community dwelling adults with chronic ( > 1 year) traumatic SCI originally identified from a specialty hospital or a state-based surveillance system. Self-reported frequency of specific prescription benzodiazepines and opioids used, concurrent use, and factors associated with use were assessed.
Results
Twenty percent reported any benzodiazepine use in the past year and 13% reported at least weekly use. Concurrent daily or weekly use of benzodiazepines and opioids was reported by 6.5%, with those individuals taking an average of 1.1 (0.4) benzodiazepines and 1.4 (0.6) opioids. Compared to younger adults, those 50–65 years old had lower odds of at least weekly benzodiazepine use (OR = 0.50, 95% CI, 0.29–0.89,
p
-value = 0.02). Non-Hispanic Blacks reported lower use of benzodiazepines compared to non-Hispanic whites (OR = 0.32, 95% CI, 0.15–0.68,
p
-value = <0.01). Weekly opioid use was associated with higher odds of using benzodiazepines (OR = 3.10, 95%CI, 1.95–4.95,
p
-value = <0.01).
Conclusions
Benzodiazepine use was commonly reported among those with SCI. Despite the potential risks, a high portion of those who reported benzodiazepine use also reported prescription opioid use. The findings highlight the need for monitoring of prescription medication use to avoid potentially risky concurrent use and adverse outcomes.</description><identifier>ISSN: 1362-4393</identifier><identifier>ISSN: 1476-5624</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/s41393-024-01030-4</identifier><identifier>PMID: 39271797</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/700/155 ; Adult ; Adults ; Aged ; Analgesics, Opioid - adverse effects ; Analgesics, Opioid - therapeutic use ; Anatomy ; Benzodiazepines ; Benzodiazepines - adverse effects ; Biomedical and Life Sciences ; Biomedicine ; Chronic Disease ; Cohort Studies ; Cross-Sectional Studies ; Female ; Human Physiology ; Humans ; Male ; Middle Aged ; Narcotics ; Neurochemistry ; Neuropsychology ; Neurosciences ; Opioids ; Self Report ; Southeastern United States - epidemiology ; Spinal cord injuries ; Spinal Cord Injuries - epidemiology ; Surveillance systems ; Young Adult</subject><ispartof>Spinal cord, 2024-11, Vol.62 (11), p.667-673</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-8f252e9867820960a2051e506cb0f463ee2febfc4d7e7827caf662a02537c33e3</cites><orcidid>0000-0001-8129-5389 ; 0000-0003-1459-4690</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41393-024-01030-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41393-024-01030-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39271797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DiPiro, Nicole D.</creatorcontrib><creatorcontrib>Dismuke-Greer, Clara E.</creatorcontrib><creatorcontrib>Krause, James S.</creatorcontrib><title>Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study design
Cross-sectional cohort study.
Objectives
To examine: (1) the self-reported frequency of specific prescription benzodiazepine use, (2) concurrent benzodiazepine and opioid use, and (3) sociodemographic, SCI, and opioid use factors associated with frequent benzodiazepine use.
Setting
Community.
Methods
Participants included 918 community dwelling adults with chronic ( > 1 year) traumatic SCI originally identified from a specialty hospital or a state-based surveillance system. Self-reported frequency of specific prescription benzodiazepines and opioids used, concurrent use, and factors associated with use were assessed.
Results
Twenty percent reported any benzodiazepine use in the past year and 13% reported at least weekly use. Concurrent daily or weekly use of benzodiazepines and opioids was reported by 6.5%, with those individuals taking an average of 1.1 (0.4) benzodiazepines and 1.4 (0.6) opioids. Compared to younger adults, those 50–65 years old had lower odds of at least weekly benzodiazepine use (OR = 0.50, 95% CI, 0.29–0.89,
p
-value = 0.02). Non-Hispanic Blacks reported lower use of benzodiazepines compared to non-Hispanic whites (OR = 0.32, 95% CI, 0.15–0.68,
p
-value = <0.01). Weekly opioid use was associated with higher odds of using benzodiazepines (OR = 3.10, 95%CI, 1.95–4.95,
p
-value = <0.01).
Conclusions
Benzodiazepine use was commonly reported among those with SCI. Despite the potential risks, a high portion of those who reported benzodiazepine use also reported prescription opioid use. The findings highlight the need for monitoring of prescription medication use to avoid potentially risky concurrent use and adverse outcomes.</description><subject>692/499</subject><subject>692/700/155</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Anatomy</subject><subject>Benzodiazepines</subject><subject>Benzodiazepines - adverse effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chronic Disease</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Narcotics</subject><subject>Neurochemistry</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>Opioids</subject><subject>Self Report</subject><subject>Southeastern United States - epidemiology</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - epidemiology</subject><subject>Surveillance systems</subject><subject>Young Adult</subject><issn>1362-4393</issn><issn>1476-5624</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kstu1TAQhiMEoqXwAiyQJTYsGvA9CZuqqspFqsSidG3NcSYnPsqxg-2A2mfiIev2HMplwWoszzf_jD1_Vb1k9C2jon2XJBOdqCmXNS0XtJaPqkMmG10rzeXjchaa17IwB9WzlDaU0o517dPqQHS8YU3XHFY_L3Ea6ohziBl7skJ_E3oHNzg7j2RJSGAb_JpAv0w5kR8uj8SOMXhnSSoMTMSG2BPnN0u8LoHkEUkKSwmQMkZPri5P3xNIKVgH2QW_V-lxG9YR5tHZ4335MQHfkzC74Pr73naECLaouJSdTc-rJwNMCV_s41F19eH869mn-uLLx89npxe1FUrnuh244ti1umk57TQFThVDRbVd0UFqgcgHXA1W9g0WpLEwaM2BciUaKwSKo-pkpzsvqy32Fn2OMJk5ui3EaxPAmb8z3o1mHb4bxpTsqFBF4c1eIYZvC6Zsti5ZnCbwGJZkBKNSiZaptqCv_0E3YYnlY-8oXhYpFW8KxXeUjSGliMPDNIyaOzeYnRtMcYO5d4ORpejVn-94KPm1_gKIHZBKyq8x_u79H9lbtZXEiw</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>DiPiro, Nicole D.</creator><creator>Dismuke-Greer, Clara E.</creator><creator>Krause, James S.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8129-5389</orcidid><orcidid>https://orcid.org/0000-0003-1459-4690</orcidid></search><sort><creationdate>20241101</creationdate><title>Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics</title><author>DiPiro, Nicole D. ; Dismuke-Greer, Clara E. ; Krause, James S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8f252e9867820960a2051e506cb0f463ee2febfc4d7e7827caf662a02537c33e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/499</topic><topic>692/700/155</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Anatomy</topic><topic>Benzodiazepines</topic><topic>Benzodiazepines - adverse effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chronic Disease</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Narcotics</topic><topic>Neurochemistry</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>Opioids</topic><topic>Self Report</topic><topic>Southeastern United States - epidemiology</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - epidemiology</topic><topic>Surveillance systems</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DiPiro, Nicole D.</creatorcontrib><creatorcontrib>Dismuke-Greer, Clara E.</creatorcontrib><creatorcontrib>Krause, James S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DiPiro, Nicole D.</au><au>Dismuke-Greer, Clara E.</au><au>Krause, James S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>62</volume><issue>11</issue><spage>667</spage><epage>673</epage><pages>667-673</pages><issn>1362-4393</issn><issn>1476-5624</issn><eissn>1476-5624</eissn><abstract>Study design
Cross-sectional cohort study.
Objectives
To examine: (1) the self-reported frequency of specific prescription benzodiazepine use, (2) concurrent benzodiazepine and opioid use, and (3) sociodemographic, SCI, and opioid use factors associated with frequent benzodiazepine use.
Setting
Community.
Methods
Participants included 918 community dwelling adults with chronic ( > 1 year) traumatic SCI originally identified from a specialty hospital or a state-based surveillance system. Self-reported frequency of specific prescription benzodiazepines and opioids used, concurrent use, and factors associated with use were assessed.
Results
Twenty percent reported any benzodiazepine use in the past year and 13% reported at least weekly use. Concurrent daily or weekly use of benzodiazepines and opioids was reported by 6.5%, with those individuals taking an average of 1.1 (0.4) benzodiazepines and 1.4 (0.6) opioids. Compared to younger adults, those 50–65 years old had lower odds of at least weekly benzodiazepine use (OR = 0.50, 95% CI, 0.29–0.89,
p
-value = 0.02). Non-Hispanic Blacks reported lower use of benzodiazepines compared to non-Hispanic whites (OR = 0.32, 95% CI, 0.15–0.68,
p
-value = <0.01). Weekly opioid use was associated with higher odds of using benzodiazepines (OR = 3.10, 95%CI, 1.95–4.95,
p
-value = <0.01).
Conclusions
Benzodiazepine use was commonly reported among those with SCI. Despite the potential risks, a high portion of those who reported benzodiazepine use also reported prescription opioid use. The findings highlight the need for monitoring of prescription medication use to avoid potentially risky concurrent use and adverse outcomes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39271797</pmid><doi>10.1038/s41393-024-01030-4</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8129-5389</orcidid><orcidid>https://orcid.org/0000-0003-1459-4690</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1362-4393 |
| ispartof | Spinal cord, 2024-11, Vol.62 (11), p.667-673 |
| issn | 1362-4393 1476-5624 1476-5624 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549035 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 692/499 692/700/155 Adult Adults Aged Analgesics, Opioid - adverse effects Analgesics, Opioid - therapeutic use Anatomy Benzodiazepines Benzodiazepines - adverse effects Biomedical and Life Sciences Biomedicine Chronic Disease Cohort Studies Cross-Sectional Studies Female Human Physiology Humans Male Middle Aged Narcotics Neurochemistry Neuropsychology Neurosciences Opioids Self Report Southeastern United States - epidemiology Spinal cord injuries Spinal Cord Injuries - epidemiology Surveillance systems Young Adult |
| title | Self-reported benzodiazepine use among adults with chronic spinal cord injury in the southeastern USA: associations with demographic, injury, and opioid use characteristics |
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