Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups
The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B (B ) levels). During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, m...
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creator | Ushiroda, Chihiro Deguchi, Kanako Yamamoto-Wada, Risako Tanaka, Hiroko Ono, Chisato Yoshida, Mitsuyoshi Sarai, Masayoshi Miyahara, Ryoji Sasaki, Hitomi Iizuka, Katsumi |
description | The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B
(B
) levels).
During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, masticatory performance, and swallowing ability (via the 10-item Eating Assessment Tool, EAT-10)) and chemical (
(HP) eradication history, HP antibody levels, and oral antacid (proton pump inhibitors) use) digestion parameters with serum ALB, PAB, and B
levels in 92 individuals (M:67, F:25).
Forty-eight percent of the participants were older than 65 years of age, 19% had decreased occlusal force, 3.2% had decreased masticatory strength, 3.2% had decreased swallowing function, 24% had a history of HP eradication, 23% were HP antibody positive, and 16% were taking oral antacid medication. Additionally, 14% and 11% of the patients had low serum ALB and PAB levels, respectively, and 14% of the patients had B
deficiency. Multivariate analysis adjusted for age, sex, body mass index, and C-reactive protein levels revealed that there were no significant associations between the physical digestion parameters and the serum PAB, ALB, or B
levels. On the other hand, there was a significant association between oral antacid use and PAB levels (β = -3.3,
= 0.04). Independent of physical or chemical digestion parameters, serum PAB and B
levels were significantly associated with protein and B
intake, respectively.
Oral antacid use may decrease serum PAB levels, indicating protein synthesis. |
doi_str_mv | 10.3390/nu16213715 |
format | Article |
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(B
) levels).
During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, masticatory performance, and swallowing ability (via the 10-item Eating Assessment Tool, EAT-10)) and chemical (
(HP) eradication history, HP antibody levels, and oral antacid (proton pump inhibitors) use) digestion parameters with serum ALB, PAB, and B
levels in 92 individuals (M:67, F:25).
Forty-eight percent of the participants were older than 65 years of age, 19% had decreased occlusal force, 3.2% had decreased masticatory strength, 3.2% had decreased swallowing function, 24% had a history of HP eradication, 23% were HP antibody positive, and 16% were taking oral antacid medication. Additionally, 14% and 11% of the patients had low serum ALB and PAB levels, respectively, and 14% of the patients had B
deficiency. Multivariate analysis adjusted for age, sex, body mass index, and C-reactive protein levels revealed that there were no significant associations between the physical digestion parameters and the serum PAB, ALB, or B
levels. On the other hand, there was a significant association between oral antacid use and PAB levels (β = -3.3,
= 0.04). Independent of physical or chemical digestion parameters, serum PAB and B
levels were significantly associated with protein and B
intake, respectively.
Oral antacid use may decrease serum PAB levels, indicating protein synthesis.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16213715</identifier><identifier>PMID: 39519547</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Administration, Oral ; Age ; Aged ; Albumin ; Amino acids ; Antacids ; Antacids - administration & dosage ; Antibodies ; Biological products ; Biomarkers - blood ; Bite Force ; Body mass index ; C-reactive protein ; Creatinine ; Deglutition ; Digestion ; East Asian People ; Female ; Food ; Glucose ; Helicobacter Infections - blood ; Helicobacter pylori ; Humans ; Japan ; Male ; Malnutrition ; Mastication ; Middle Aged ; Nutritional Status ; Prealbumin - analysis ; Prealbumin - metabolism ; Protein biosynthesis ; Protein synthesis ; Proteins ; Questionnaires ; Regression analysis ; Swallowing ; Uric acid ; Viral antibodies ; Vitamin B 12 - blood ; Vitamins</subject><ispartof>Nutrients, 2024-10, Vol.16 (21), p.3715</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c363t-a5c7c2b81226dfe58d1b54029b1df6fdf1748d0d98a5ff6c1fcc73eb9ca246663</cites><orcidid>0000-0002-6547-9732 ; 0000-0002-9837-6238</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547716/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547716/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39519547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ushiroda, Chihiro</creatorcontrib><creatorcontrib>Deguchi, Kanako</creatorcontrib><creatorcontrib>Yamamoto-Wada, Risako</creatorcontrib><creatorcontrib>Tanaka, Hiroko</creatorcontrib><creatorcontrib>Ono, Chisato</creatorcontrib><creatorcontrib>Yoshida, Mitsuyoshi</creatorcontrib><creatorcontrib>Sarai, Masayoshi</creatorcontrib><creatorcontrib>Miyahara, Ryoji</creatorcontrib><creatorcontrib>Sasaki, Hitomi</creatorcontrib><creatorcontrib>Iizuka, Katsumi</creatorcontrib><title>Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B
(B
) levels).
During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, masticatory performance, and swallowing ability (via the 10-item Eating Assessment Tool, EAT-10)) and chemical (
(HP) eradication history, HP antibody levels, and oral antacid (proton pump inhibitors) use) digestion parameters with serum ALB, PAB, and B
levels in 92 individuals (M:67, F:25).
Forty-eight percent of the participants were older than 65 years of age, 19% had decreased occlusal force, 3.2% had decreased masticatory strength, 3.2% had decreased swallowing function, 24% had a history of HP eradication, 23% were HP antibody positive, and 16% were taking oral antacid medication. Additionally, 14% and 11% of the patients had low serum ALB and PAB levels, respectively, and 14% of the patients had B
deficiency. Multivariate analysis adjusted for age, sex, body mass index, and C-reactive protein levels revealed that there were no significant associations between the physical digestion parameters and the serum PAB, ALB, or B
levels. On the other hand, there was a significant association between oral antacid use and PAB levels (β = -3.3,
= 0.04). Independent of physical or chemical digestion parameters, serum PAB and B
levels were significantly associated with protein and B
intake, respectively.
Oral antacid use may decrease serum PAB levels, indicating protein synthesis.</description><subject>Administration, Oral</subject><subject>Age</subject><subject>Aged</subject><subject>Albumin</subject><subject>Amino acids</subject><subject>Antacids</subject><subject>Antacids - administration & dosage</subject><subject>Antibodies</subject><subject>Biological products</subject><subject>Biomarkers - blood</subject><subject>Bite Force</subject><subject>Body mass index</subject><subject>C-reactive protein</subject><subject>Creatinine</subject><subject>Deglutition</subject><subject>Digestion</subject><subject>East Asian People</subject><subject>Female</subject><subject>Food</subject><subject>Glucose</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Mastication</subject><subject>Middle Aged</subject><subject>Nutritional Status</subject><subject>Prealbumin - analysis</subject><subject>Prealbumin - metabolism</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Swallowing</subject><subject>Uric acid</subject><subject>Viral antibodies</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamins</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkt9vFCEQx4nR2Obsi3-AIfHFmFxdYBd2n8zlUm3NxZroPRMWhj3qLpywe-b-e9m09ocRHpgMn_kOMwxCr0lxzlhTfPAT4ZQwQapn6JQWgi45L9nzR_YJOkvpppiXKARnL9EJayrSVKU4RcfrqHq88qPSzuBtAnyV8Ffo1OgO0B_xKqWgnRrB4N9u3OHvEKcBf4ug-nYanMcbyFzC2fqi9srDrOCNOzgzqezfegOxC853-DLHZIX1DvTPaZ9eoRc2E3B2dy7Q9tPFj_XlcnP9-Wq92iw142xcqkoLTduaUMqNhao2pK3KgjYtMZZbY4koa1OYplaVtVwTq7Vg0DZa0ZJzzhbo463ufmoHMBr8mEuW--gGFY8yKCef3ni3k104SEJyhwSZFd7dKcTwa4I0ysElDX2fyw1TkozQWpTl_A0L9PYf9CZM0ef6ZornZ1NWPVCd6kE6b0NOrGdRuapzVlo0pcjU-X-ovA0MTgcP1mX_k4D3twE6hpQi2PsiSSHnYZEPw5LhN4_bco_-HQ32B-3lueg</recordid><startdate>20241030</startdate><enddate>20241030</enddate><creator>Ushiroda, Chihiro</creator><creator>Deguchi, Kanako</creator><creator>Yamamoto-Wada, Risako</creator><creator>Tanaka, Hiroko</creator><creator>Ono, Chisato</creator><creator>Yoshida, Mitsuyoshi</creator><creator>Sarai, Masayoshi</creator><creator>Miyahara, Ryoji</creator><creator>Sasaki, Hitomi</creator><creator>Iizuka, Katsumi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6547-9732</orcidid><orcidid>https://orcid.org/0000-0002-9837-6238</orcidid></search><sort><creationdate>20241030</creationdate><title>Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups</title><author>Ushiroda, Chihiro ; Deguchi, Kanako ; Yamamoto-Wada, Risako ; Tanaka, Hiroko ; Ono, Chisato ; Yoshida, Mitsuyoshi ; Sarai, Masayoshi ; Miyahara, Ryoji ; Sasaki, Hitomi ; Iizuka, Katsumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-a5c7c2b81226dfe58d1b54029b1df6fdf1748d0d98a5ff6c1fcc73eb9ca246663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Administration, Oral</topic><topic>Age</topic><topic>Aged</topic><topic>Albumin</topic><topic>Amino acids</topic><topic>Antacids</topic><topic>Antacids - administration & dosage</topic><topic>Antibodies</topic><topic>Biological products</topic><topic>Biomarkers - blood</topic><topic>Bite Force</topic><topic>Body mass index</topic><topic>C-reactive protein</topic><topic>Creatinine</topic><topic>Deglutition</topic><topic>Digestion</topic><topic>East Asian People</topic><topic>Female</topic><topic>Food</topic><topic>Glucose</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Mastication</topic><topic>Middle Aged</topic><topic>Nutritional Status</topic><topic>Prealbumin - analysis</topic><topic>Prealbumin - metabolism</topic><topic>Protein biosynthesis</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Swallowing</topic><topic>Uric acid</topic><topic>Viral antibodies</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ushiroda, Chihiro</creatorcontrib><creatorcontrib>Deguchi, Kanako</creatorcontrib><creatorcontrib>Yamamoto-Wada, Risako</creatorcontrib><creatorcontrib>Tanaka, Hiroko</creatorcontrib><creatorcontrib>Ono, Chisato</creatorcontrib><creatorcontrib>Yoshida, Mitsuyoshi</creatorcontrib><creatorcontrib>Sarai, Masayoshi</creatorcontrib><creatorcontrib>Miyahara, Ryoji</creatorcontrib><creatorcontrib>Sasaki, Hitomi</creatorcontrib><creatorcontrib>Iizuka, Katsumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ushiroda, Chihiro</au><au>Deguchi, Kanako</au><au>Yamamoto-Wada, Risako</au><au>Tanaka, Hiroko</au><au>Ono, Chisato</au><au>Yoshida, Mitsuyoshi</au><au>Sarai, Masayoshi</au><au>Miyahara, Ryoji</au><au>Sasaki, Hitomi</au><au>Iizuka, Katsumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2024-10-30</date><risdate>2024</risdate><volume>16</volume><issue>21</issue><spage>3715</spage><pages>3715-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B
(B
) levels).
During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, masticatory performance, and swallowing ability (via the 10-item Eating Assessment Tool, EAT-10)) and chemical (
(HP) eradication history, HP antibody levels, and oral antacid (proton pump inhibitors) use) digestion parameters with serum ALB, PAB, and B
levels in 92 individuals (M:67, F:25).
Forty-eight percent of the participants were older than 65 years of age, 19% had decreased occlusal force, 3.2% had decreased masticatory strength, 3.2% had decreased swallowing function, 24% had a history of HP eradication, 23% were HP antibody positive, and 16% were taking oral antacid medication. Additionally, 14% and 11% of the patients had low serum ALB and PAB levels, respectively, and 14% of the patients had B
deficiency. Multivariate analysis adjusted for age, sex, body mass index, and C-reactive protein levels revealed that there were no significant associations between the physical digestion parameters and the serum PAB, ALB, or B
levels. On the other hand, there was a significant association between oral antacid use and PAB levels (β = -3.3,
= 0.04). Independent of physical or chemical digestion parameters, serum PAB and B
levels were significantly associated with protein and B
intake, respectively.
Oral antacid use may decrease serum PAB levels, indicating protein synthesis.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39519547</pmid><doi>10.3390/nu16213715</doi><orcidid>https://orcid.org/0000-0002-6547-9732</orcidid><orcidid>https://orcid.org/0000-0002-9837-6238</orcidid><oa>free_for_read</oa></addata></record> |
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source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
subjects | Administration, Oral Age Aged Albumin Amino acids Antacids Antacids - administration & dosage Antibodies Biological products Biomarkers - blood Bite Force Body mass index C-reactive protein Creatinine Deglutition Digestion East Asian People Female Food Glucose Helicobacter Infections - blood Helicobacter pylori Humans Japan Male Malnutrition Mastication Middle Aged Nutritional Status Prealbumin - analysis Prealbumin - metabolism Protein biosynthesis Protein synthesis Proteins Questionnaires Regression analysis Swallowing Uric acid Viral antibodies Vitamin B 12 - blood Vitamins |
title | Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups |
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