Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups

The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B (B ) levels). During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, m...

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Veröffentlicht in:Nutrients 2024-10, Vol.16 (21), p.3715
Hauptverfasser: Ushiroda, Chihiro, Deguchi, Kanako, Yamamoto-Wada, Risako, Tanaka, Hiroko, Ono, Chisato, Yoshida, Mitsuyoshi, Sarai, Masayoshi, Miyahara, Ryoji, Sasaki, Hitomi, Iizuka, Katsumi
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container_end_page
container_issue 21
container_start_page 3715
container_title Nutrients
container_volume 16
creator Ushiroda, Chihiro
Deguchi, Kanako
Yamamoto-Wada, Risako
Tanaka, Hiroko
Ono, Chisato
Yoshida, Mitsuyoshi
Sarai, Masayoshi
Miyahara, Ryoji
Sasaki, Hitomi
Iizuka, Katsumi
description The aim of this study is to investigate the association between physical and chemical digestion and nutrition markers (serum albumin (ALB), prealbumin (PAB), and vitamin B (B ) levels). During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, masticatory performance, and swallowing ability (via the 10-item Eating Assessment Tool, EAT-10)) and chemical ( (HP) eradication history, HP antibody levels, and oral antacid (proton pump inhibitors) use) digestion parameters with serum ALB, PAB, and B levels in 92 individuals (M:67, F:25). Forty-eight percent of the participants were older than 65 years of age, 19% had decreased occlusal force, 3.2% had decreased masticatory strength, 3.2% had decreased swallowing function, 24% had a history of HP eradication, 23% were HP antibody positive, and 16% were taking oral antacid medication. Additionally, 14% and 11% of the patients had low serum ALB and PAB levels, respectively, and 14% of the patients had B deficiency. Multivariate analysis adjusted for age, sex, body mass index, and C-reactive protein levels revealed that there were no significant associations between the physical digestion parameters and the serum PAB, ALB, or B levels. On the other hand, there was a significant association between oral antacid use and PAB levels (β = -3.3, = 0.04). Independent of physical or chemical digestion parameters, serum PAB and B levels were significantly associated with protein and B intake, respectively. Oral antacid use may decrease serum PAB levels, indicating protein synthesis.
doi_str_mv 10.3390/nu16213715
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During a detailed checkup at Fujita Health University, we examined the associations of physical (occlusal force, masticatory performance, and swallowing ability (via the 10-item Eating Assessment Tool, EAT-10)) and chemical ( (HP) eradication history, HP antibody levels, and oral antacid (proton pump inhibitors) use) digestion parameters with serum ALB, PAB, and B levels in 92 individuals (M:67, F:25). Forty-eight percent of the participants were older than 65 years of age, 19% had decreased occlusal force, 3.2% had decreased masticatory strength, 3.2% had decreased swallowing function, 24% had a history of HP eradication, 23% were HP antibody positive, and 16% were taking oral antacid medication. Additionally, 14% and 11% of the patients had low serum ALB and PAB levels, respectively, and 14% of the patients had B deficiency. 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subjects Administration, Oral
Age
Aged
Albumin
Amino acids
Antacids
Antacids - administration & dosage
Antibodies
Biological products
Biomarkers - blood
Bite Force
Body mass index
C-reactive protein
Creatinine
Deglutition
Digestion
East Asian People
Female
Food
Glucose
Helicobacter Infections - blood
Helicobacter pylori
Humans
Japan
Male
Malnutrition
Mastication
Middle Aged
Nutritional Status
Prealbumin - analysis
Prealbumin - metabolism
Protein biosynthesis
Protein synthesis
Proteins
Questionnaires
Regression analysis
Swallowing
Uric acid
Viral antibodies
Vitamin B 12 - blood
Vitamins
title Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups
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