Silicon-Enriched Meat Ameliorates Diabetic Dyslipidemia by Improving Cholesterol, Bile Acid Metabolism and Ileal Barrier Integrity in Rats with Late-Stage Type 2 Diabetes
Silicon as a functional ingredient of restructured meat (RM) shows antidiabetic and hypocholesterolemic effects in a type 2 diabetes mellitus (T2DM) rat model. The present paper investigated the mechanisms involved in this cholesterol-lowering effect by studying the impact of silicon-RM consumption...
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| Veröffentlicht in: | International journal of molecular sciences 2024-11, Vol.25 (21), p.11405 |
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| creator | Hernández-Martín, Marina Garcimartín, Alba Bocanegra, Aránzazu Macho-González, Adrián García-Fernández, Rosa A de Pascual-Teresa, Sonia Redondo-Castillejo, Rocío Bastida, Sara Sánchez-Muniz, Francisco J Benedí, Juana López-Oliva, Mª Elvira |
| description | Silicon as a functional ingredient of restructured meat (RM) shows antidiabetic and hypocholesterolemic effects in a type 2 diabetes mellitus (T2DM) rat model. The present paper investigated the mechanisms involved in this cholesterol-lowering effect by studying the impact of silicon-RM consumption on bile acid (BA) and cholesterol metabolism. In addition, the main effects of cecal BA and short-chain fatty acids derived from the microbiota on intestinal barrier integrity were also tested. Rats were fed an RM high-saturated-fat, high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection (LD group) and for an 8 wk. period. Silicon-RM was included in the HSFHCD as a functional food (LD-Si group). An early-stage T2DM group fed a high-saturated-fat diet (ED group) was used as a reference. Silicon decreased the BA pool with a higher hydrophilic BA profile and a lower ability to digest fat and decreased the damaging effects, increasing the occludin levels and the integrity of the intestinal barrier. The ileal BA uptake and hepatic BA synthesis through CYP7A1 were reduced by FXR/FGF15 signaling activation. The silicon up-regulated the hepatic and ileal FXR and LXRα/β, improving transintestinal cholesterol (TICE), biliary BA and cholesterol effluxes. The inclusion of silicon in meat products could be used as a new therapeutic nutritional tool in the treatment of diabetic dyslipidemia. |
| doi_str_mv | 10.3390/ijms252111405 |
| format | Article |
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The present paper investigated the mechanisms involved in this cholesterol-lowering effect by studying the impact of silicon-RM consumption on bile acid (BA) and cholesterol metabolism. In addition, the main effects of cecal BA and short-chain fatty acids derived from the microbiota on intestinal barrier integrity were also tested. Rats were fed an RM high-saturated-fat, high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection (LD group) and for an 8 wk. period. Silicon-RM was included in the HSFHCD as a functional food (LD-Si group). An early-stage T2DM group fed a high-saturated-fat diet (ED group) was used as a reference. Silicon decreased the BA pool with a higher hydrophilic BA profile and a lower ability to digest fat and decreased the damaging effects, increasing the occludin levels and the integrity of the intestinal barrier. The ileal BA uptake and hepatic BA synthesis through CYP7A1 were reduced by FXR/FGF15 signaling activation. The silicon up-regulated the hepatic and ileal FXR and LXRα/β, improving transintestinal cholesterol (TICE), biliary BA and cholesterol effluxes. The inclusion of silicon in meat products could be used as a new therapeutic nutritional tool in the treatment of diabetic dyslipidemia.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252111405</identifier><identifier>PMID: 39518958</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Anticholesteremic agents ; Bile ; Bile acids ; Bile Acids and Salts - metabolism ; Cholesterol ; Cholesterol - metabolism ; Diabetes ; Diabetes Mellitus, Experimental - diet therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diet therapy ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diet ; Diet, High-Fat - adverse effects ; Dyslipidemias - diet therapy ; Dyslipidemias - drug therapy ; Dyslipidemias - metabolism ; Fatty acids ; Feces ; Functional foods ; Functional foods & nutraceuticals ; Glucose ; Hyperglycemia ; Ileum - drug effects ; Ileum - metabolism ; Ileum - pathology ; Insulin resistance ; Lipids ; Liver ; Male ; Meat ; Metabolic disorders ; Metabolites ; Physiological aspects ; Plasma ; Rats ; Rats, Wistar ; Silicon ; Silicon - pharmacology ; Small intestine ; Type 2 diabetes</subject><ispartof>International journal of molecular sciences, 2024-11, Vol.25 (21), p.11405</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c330t-189393c62887557f7326a55c82e7111291c2d5c605db8139044bee5686b92d7d3</cites><orcidid>0000-0002-0615-9149 ; 0000-0001-8546-8507 ; 0000-0001-7644-1759 ; 0000-0002-6987-4203 ; 0000-0001-6864-5719 ; 0000-0002-2660-5126 ; 0000-0001-7040-2126 ; 0000-0002-0363-3976</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547133/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547133/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39518958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernández-Martín, Marina</creatorcontrib><creatorcontrib>Garcimartín, Alba</creatorcontrib><creatorcontrib>Bocanegra, Aránzazu</creatorcontrib><creatorcontrib>Macho-González, Adrián</creatorcontrib><creatorcontrib>García-Fernández, Rosa A</creatorcontrib><creatorcontrib>de Pascual-Teresa, Sonia</creatorcontrib><creatorcontrib>Redondo-Castillejo, Rocío</creatorcontrib><creatorcontrib>Bastida, Sara</creatorcontrib><creatorcontrib>Sánchez-Muniz, Francisco J</creatorcontrib><creatorcontrib>Benedí, Juana</creatorcontrib><creatorcontrib>López-Oliva, Mª Elvira</creatorcontrib><title>Silicon-Enriched Meat Ameliorates Diabetic Dyslipidemia by Improving Cholesterol, Bile Acid Metabolism and Ileal Barrier Integrity in Rats with Late-Stage Type 2 Diabetes</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Silicon as a functional ingredient of restructured meat (RM) shows antidiabetic and hypocholesterolemic effects in a type 2 diabetes mellitus (T2DM) rat model. The present paper investigated the mechanisms involved in this cholesterol-lowering effect by studying the impact of silicon-RM consumption on bile acid (BA) and cholesterol metabolism. In addition, the main effects of cecal BA and short-chain fatty acids derived from the microbiota on intestinal barrier integrity were also tested. Rats were fed an RM high-saturated-fat, high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection (LD group) and for an 8 wk. period. Silicon-RM was included in the HSFHCD as a functional food (LD-Si group). An early-stage T2DM group fed a high-saturated-fat diet (ED group) was used as a reference. Silicon decreased the BA pool with a higher hydrophilic BA profile and a lower ability to digest fat and decreased the damaging effects, increasing the occludin levels and the integrity of the intestinal barrier. The ileal BA uptake and hepatic BA synthesis through CYP7A1 were reduced by FXR/FGF15 signaling activation. The silicon up-regulated the hepatic and ileal FXR and LXRα/β, improving transintestinal cholesterol (TICE), biliary BA and cholesterol effluxes. The inclusion of silicon in meat products could be used as a new therapeutic nutritional tool in the treatment of diabetic dyslipidemia.</description><subject>Animals</subject><subject>Anticholesteremic agents</subject><subject>Bile</subject><subject>Bile acids</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - diet therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diet therapy</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dyslipidemias - diet therapy</subject><subject>Dyslipidemias - drug therapy</subject><subject>Dyslipidemias - metabolism</subject><subject>Fatty acids</subject><subject>Feces</subject><subject>Functional foods</subject><subject>Functional foods & nutraceuticals</subject><subject>Glucose</subject><subject>Hyperglycemia</subject><subject>Ileum - 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| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2024-11, Vol.25 (21), p.11405 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11547133 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Anticholesteremic agents Bile Bile acids Bile Acids and Salts - metabolism Cholesterol Cholesterol - metabolism Diabetes Diabetes Mellitus, Experimental - diet therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diet therapy Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diet Diet, High-Fat - adverse effects Dyslipidemias - diet therapy Dyslipidemias - drug therapy Dyslipidemias - metabolism Fatty acids Feces Functional foods Functional foods & nutraceuticals Glucose Hyperglycemia Ileum - drug effects Ileum - metabolism Ileum - pathology Insulin resistance Lipids Liver Male Meat Metabolic disorders Metabolites Physiological aspects Plasma Rats Rats, Wistar Silicon Silicon - pharmacology Small intestine Type 2 diabetes |
| title | Silicon-Enriched Meat Ameliorates Diabetic Dyslipidemia by Improving Cholesterol, Bile Acid Metabolism and Ileal Barrier Integrity in Rats with Late-Stage Type 2 Diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T02%3A17%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Silicon-Enriched%20Meat%20Ameliorates%20Diabetic%20Dyslipidemia%20by%20Improving%20Cholesterol,%20Bile%20Acid%20Metabolism%20and%20Ileal%20Barrier%20Integrity%20in%20Rats%20with%20Late-Stage%20Type%202%20Diabetes&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Hern%C3%A1ndez-Mart%C3%ADn,%20Marina&rft.date=2024-11-01&rft.volume=25&rft.issue=21&rft.spage=11405&rft.pages=11405-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms252111405&rft_dat=%3Cgale_pubme%3EA815345818%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3126047249&rft_id=info:pmid/39518958&rft_galeid=A815345818&rfr_iscdi=true |