Pathological Alterations in Heart Mitochondria in a Rat Model of Isoprenaline-Induced Myocardial Injury and Their Correction with Water-Soluble Taxifolin

Mitochondrial damage and associated oxidative stress are considered to be major contributory factors in cardiac pathology. One of the most potent naturally occurring antioxidants is taxifolin, especially in its water-soluble form. Herein, the effect of a 14-day course of the peroral application of t...

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Veröffentlicht in:	International journal of molecular sciences 2024-11, Vol.25 (21), p.11596
Hauptverfasser:	Belosludtseva, Natalia V, Uryupina, Tatyana A, Pavlik, Lyubov L, Mikheeva, Irina B, Talanov, Eugeny Yu, Venediktova, Natalya I, Serov, Dmitriy A, Stepanov, Mikhail R, Ananyan, Mikhail A, Mironova, Galina D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Cardiomyocytes Care and treatment Catecholamines Cell death Development and progression Disease Models, Animal Electrocardiography Enzymes Glutathione Peroxidase - metabolism Health aspects Heart attacks Heart failure Homeostasis Ischemia Isoproterenol - adverse effects Male Mitochondria Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Mortality Myocardium - metabolism Myocardium - pathology Myocardium - ultrastructure Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxidative stress Oxidative Stress - drug effects Pathology Physiological aspects Quercetin Quercetin - analogs & derivatives Quercetin - pharmacology Rats Rats, Wistar Superoxide Dismutase - metabolism
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