Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids

The atrioventricular (AV) conduction axis provides electrical continuity between the atrial and ventricular chambers. The “nodal” cardiomyocytes populating this region (AV canal in the embryo, AV node from fetal stages onward) propagate impulses slowly, ensuring sequential contraction of the chamber...

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Veröffentlicht in:	Cell stem cell 2024-11, Vol.31 (11), p.1667-1684.e6
Hauptverfasser:	Li, Jiuru, Wiesinger, Alexandra, Fokkert, Lianne, Bakker, Priscilla, de Vries, Dylan K., Tijsen, Anke J., Pinto, Yigal M., Verkerk, Arie O., Christoffels, Vincent M., Boink, Gerard J.J., Devalla, Harsha D.
Format:	Artikel
Sprache:	eng
Schlagworte:	assembloid Atrioventricular Node atrioventricular canal Calcium - metabolism cardiomyocyte Cell Differentiation conduction differentiation electrophysiology Heart Conduction System heart disease Humans iPSC LMNA Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism
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