Circadian Regulation of Lipid Metabolism during Pregnancy
A cluster of metabolic changes occur to provide energy for fetal growth and development during pregnancy. There is a burgeoning body of research highlighting the pivotal role of circadian rhythms in the pathogenesis of metabolic disorders and lipid homeostasis in mammals. Perturbations of the circad...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2024-11, Vol.25 (21), p.11491 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 21 |
| container_start_page | 11491 |
| container_title | International journal of molecular sciences |
| container_volume | 25 |
| creator | Luo, Yujie Meng, Xinhang Cui, Liyuan Wang, Songcun |
| description | A cluster of metabolic changes occur to provide energy for fetal growth and development during pregnancy. There is a burgeoning body of research highlighting the pivotal role of circadian rhythms in the pathogenesis of metabolic disorders and lipid homeostasis in mammals. Perturbations of the circadian system and lipid metabolism during gestation might be responsible for a variety of adverse reproductive outcomes comprising miscarriage, gestational diabetes mellitus, and preeclampsia. Growing studies have confirmed that resynchronizing circadian rhythms might alleviate metabolic disturbance. However, there is no clear evidence regarding the specific mechanisms by which the diurnal rhythm regulates lipid metabolism during pregnancy. In this review, we summarize previous knowledge on the strong interaction among the circadian clock, lipid metabolism, and pregnancy. Analyzing the circadian clock genes will improve our understanding of how circadian rhythms are implicated in complex lipid metabolic disorders during pregnancy. Exploring the potential of resynchronizing these circadian rhythms to disrupt abnormal lipid metabolism could also result in a breakthrough in reducing adverse pregnancy outcomes. |
| doi_str_mv | 10.3390/ijms252111491 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11545986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A815345380</galeid><sourcerecordid>A815345380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-a5f3151c1a2d47518b5052b7c0893b7277f37b2325faac1c71ce32ec84de52773</originalsourceid><addsrcrecordid>eNptkctLJDEQxoO4qKt79CoNXvbSbiqPTuckMrgPGFHEPYd0Ot1m6E7GpFvwv98MPtYRyaFC6ldfpepD6BjwGaUS_3CrMRFOAIBJ2EEHwAgpMa7E7rv7Pvqa0gpjQgmXe2ifSg4SM3aA5MJFo1unfXFr-3nQkwu-CF2xdGvXFld20k0YXBqLdo7O98VNtL3X3jwdoS-dHpL99hIP0d-fl3eL3-Xy-tefxcWyNLSSU6l5R4GDAU1aJjjUDcecNMLgWtJGECE6KprNxzqtDRgBxlJiTc1ay3OWHqLzZ9313Iy2NdZPUQ9qHd2o45MK2qntjHf3qg-PCoAzLusqK3x_UYjhYbZpUqNLxg6D9jbMSVEgtWAMqMzo6Qd0Febo83wbqsKsqiT9T_V6sMr5LuTGZiOqLmrglHFa40ydfULl09rRmeBt5_L7VkH5XGBiSCna7m1IwGpjttoyO_Mn7zfzRr-6S_8Bgd6isA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3126046693</pqid></control><display><type>article</type><title>Circadian Regulation of Lipid Metabolism during Pregnancy</title><source>MEDLINE</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Luo, Yujie ; Meng, Xinhang ; Cui, Liyuan ; Wang, Songcun</creator><creatorcontrib>Luo, Yujie ; Meng, Xinhang ; Cui, Liyuan ; Wang, Songcun</creatorcontrib><description>A cluster of metabolic changes occur to provide energy for fetal growth and development during pregnancy. There is a burgeoning body of research highlighting the pivotal role of circadian rhythms in the pathogenesis of metabolic disorders and lipid homeostasis in mammals. Perturbations of the circadian system and lipid metabolism during gestation might be responsible for a variety of adverse reproductive outcomes comprising miscarriage, gestational diabetes mellitus, and preeclampsia. Growing studies have confirmed that resynchronizing circadian rhythms might alleviate metabolic disturbance. However, there is no clear evidence regarding the specific mechanisms by which the diurnal rhythm regulates lipid metabolism during pregnancy. In this review, we summarize previous knowledge on the strong interaction among the circadian clock, lipid metabolism, and pregnancy. Analyzing the circadian clock genes will improve our understanding of how circadian rhythms are implicated in complex lipid metabolic disorders during pregnancy. Exploring the potential of resynchronizing these circadian rhythms to disrupt abnormal lipid metabolism could also result in a breakthrough in reducing adverse pregnancy outcomes.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252111491</identifier><identifier>PMID: 39519044</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Body fat ; Cholesterol ; Circadian Clocks ; Circadian rhythm ; Circadian Rhythm - physiology ; Circadian rhythms ; Enzymes ; Fatty acids ; Female ; Genes ; Health aspects ; Humans ; Lipid Metabolism ; Lipids ; Lipoproteins ; Liver ; Metabolic disorders ; Miscarriage ; Oxidation ; Physiology ; Pregnancy ; Pregnant women ; Premature birth ; Proteins ; Review ; Womens health</subject><ispartof>International journal of molecular sciences, 2024-11, Vol.25 (21), p.11491</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c369t-a5f3151c1a2d47518b5052b7c0893b7277f37b2325faac1c71ce32ec84de52773</cites><orcidid>0000-0001-6484-4358</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545986/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545986/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39519044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Yujie</creatorcontrib><creatorcontrib>Meng, Xinhang</creatorcontrib><creatorcontrib>Cui, Liyuan</creatorcontrib><creatorcontrib>Wang, Songcun</creatorcontrib><title>Circadian Regulation of Lipid Metabolism during Pregnancy</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>A cluster of metabolic changes occur to provide energy for fetal growth and development during pregnancy. There is a burgeoning body of research highlighting the pivotal role of circadian rhythms in the pathogenesis of metabolic disorders and lipid homeostasis in mammals. Perturbations of the circadian system and lipid metabolism during gestation might be responsible for a variety of adverse reproductive outcomes comprising miscarriage, gestational diabetes mellitus, and preeclampsia. Growing studies have confirmed that resynchronizing circadian rhythms might alleviate metabolic disturbance. However, there is no clear evidence regarding the specific mechanisms by which the diurnal rhythm regulates lipid metabolism during pregnancy. In this review, we summarize previous knowledge on the strong interaction among the circadian clock, lipid metabolism, and pregnancy. Analyzing the circadian clock genes will improve our understanding of how circadian rhythms are implicated in complex lipid metabolic disorders during pregnancy. Exploring the potential of resynchronizing these circadian rhythms to disrupt abnormal lipid metabolism could also result in a breakthrough in reducing adverse pregnancy outcomes.</description><subject>Animals</subject><subject>Body fat</subject><subject>Cholesterol</subject><subject>Circadian Clocks</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>Enzymes</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Liver</subject><subject>Metabolic disorders</subject><subject>Miscarriage</subject><subject>Oxidation</subject><subject>Physiology</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Premature birth</subject><subject>Proteins</subject><subject>Review</subject><subject>Womens health</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkctLJDEQxoO4qKt79CoNXvbSbiqPTuckMrgPGFHEPYd0Ot1m6E7GpFvwv98MPtYRyaFC6ldfpepD6BjwGaUS_3CrMRFOAIBJ2EEHwAgpMa7E7rv7Pvqa0gpjQgmXe2ifSg4SM3aA5MJFo1unfXFr-3nQkwu-CF2xdGvXFld20k0YXBqLdo7O98VNtL3X3jwdoS-dHpL99hIP0d-fl3eL3-Xy-tefxcWyNLSSU6l5R4GDAU1aJjjUDcecNMLgWtJGECE6KprNxzqtDRgBxlJiTc1ay3OWHqLzZ9313Iy2NdZPUQ9qHd2o45MK2qntjHf3qg-PCoAzLusqK3x_UYjhYbZpUqNLxg6D9jbMSVEgtWAMqMzo6Qd0Febo83wbqsKsqiT9T_V6sMr5LuTGZiOqLmrglHFa40ydfULl09rRmeBt5_L7VkH5XGBiSCna7m1IwGpjttoyO_Mn7zfzRr-6S_8Bgd6isA</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Luo, Yujie</creator><creator>Meng, Xinhang</creator><creator>Cui, Liyuan</creator><creator>Wang, Songcun</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6484-4358</orcidid></search><sort><creationdate>20241101</creationdate><title>Circadian Regulation of Lipid Metabolism during Pregnancy</title><author>Luo, Yujie ; Meng, Xinhang ; Cui, Liyuan ; Wang, Songcun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-a5f3151c1a2d47518b5052b7c0893b7277f37b2325faac1c71ce32ec84de52773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Body fat</topic><topic>Cholesterol</topic><topic>Circadian Clocks</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Circadian rhythms</topic><topic>Enzymes</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Genes</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Liver</topic><topic>Metabolic disorders</topic><topic>Miscarriage</topic><topic>Oxidation</topic><topic>Physiology</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Premature birth</topic><topic>Proteins</topic><topic>Review</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Yujie</creatorcontrib><creatorcontrib>Meng, Xinhang</creatorcontrib><creatorcontrib>Cui, Liyuan</creatorcontrib><creatorcontrib>Wang, Songcun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Yujie</au><au>Meng, Xinhang</au><au>Cui, Liyuan</au><au>Wang, Songcun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian Regulation of Lipid Metabolism during Pregnancy</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>25</volume><issue>21</issue><spage>11491</spage><pages>11491-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>A cluster of metabolic changes occur to provide energy for fetal growth and development during pregnancy. There is a burgeoning body of research highlighting the pivotal role of circadian rhythms in the pathogenesis of metabolic disorders and lipid homeostasis in mammals. Perturbations of the circadian system and lipid metabolism during gestation might be responsible for a variety of adverse reproductive outcomes comprising miscarriage, gestational diabetes mellitus, and preeclampsia. Growing studies have confirmed that resynchronizing circadian rhythms might alleviate metabolic disturbance. However, there is no clear evidence regarding the specific mechanisms by which the diurnal rhythm regulates lipid metabolism during pregnancy. In this review, we summarize previous knowledge on the strong interaction among the circadian clock, lipid metabolism, and pregnancy. Analyzing the circadian clock genes will improve our understanding of how circadian rhythms are implicated in complex lipid metabolic disorders during pregnancy. Exploring the potential of resynchronizing these circadian rhythms to disrupt abnormal lipid metabolism could also result in a breakthrough in reducing adverse pregnancy outcomes.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39519044</pmid><doi>10.3390/ijms252111491</doi><orcidid>https://orcid.org/0000-0001-6484-4358</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2024-11, Vol.25 (21), p.11491 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11545986 |
| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Body fat Cholesterol Circadian Clocks Circadian rhythm Circadian Rhythm - physiology Circadian rhythms Enzymes Fatty acids Female Genes Health aspects Humans Lipid Metabolism Lipids Lipoproteins Liver Metabolic disorders Miscarriage Oxidation Physiology Pregnancy Pregnant women Premature birth Proteins Review Womens health |
| title | Circadian Regulation of Lipid Metabolism during Pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T23%3A00%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circadian%20Regulation%20of%20Lipid%20Metabolism%20during%20Pregnancy&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Luo,%20Yujie&rft.date=2024-11-01&rft.volume=25&rft.issue=21&rft.spage=11491&rft.pages=11491-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms252111491&rft_dat=%3Cgale_pubme%3EA815345380%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3126046693&rft_id=info:pmid/39519044&rft_galeid=A815345380&rfr_iscdi=true |