The Application of Untargeted Metabolomic Approaches for the Search of Common Bioavailable Metabolites in Human Plasma Samples from Lippia citriodora and Olea europaea Extracts

Lippia citriodora and Olea europaea are known for their shared common bioactivities. Although both matrices are rich in similar families of bioactive compounds, their specific phytochemical compounds are mostly different. Since these compounds can be metabolized in the organism, this study hypothesi...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2024-11, Vol.72 (44), p.24879-24893
Hauptverfasser:	Villegas-Aguilar, María del Carmen, Cádiz-Gurrea, María de la Luz, Sánchez-Marzo, Noelia, Barrajón-Catalán, Enrique, Arráez-Román, David, Fernández-Ochoa, Álvaro, Segura-Carretero, Antonio
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Sprache:	eng
Schlagworte:	Adult Aloysia citrodora bioavailability Biological Availability blood Chromatography, High Pressure Liquid clinical trials Double-Blind Method Female food chemistry homovanillic acid Humans Lippia - chemistry Lippia - metabolism Male metabolites Metabolomics Olea - chemistry Olea - metabolism Olea europaea Omics Technologies Applied to Agriculture and Food phytochemicals Plant Extracts - blood Plant Extracts - chemistry Plant Extracts - metabolism sulfates Young Adult
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container_title	Journal of agricultural and food chemistry
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creator	Villegas-Aguilar, María del Carmen Cádiz-Gurrea, María de la Luz Sánchez-Marzo, Noelia Barrajón-Catalán, Enrique Arráez-Román, David Fernández-Ochoa, Álvaro Segura-Carretero, Antonio
description	Lippia citriodora and Olea europaea are known for their shared common bioactivities. Although both matrices are rich in similar families of bioactive compounds, their specific phytochemical compounds are mostly different. Since these compounds can be metabolized in the organism, this study hypothesized that common bioavailable metabolites may contribute to their similar bioactive effects. To test this, an acute double-blind intervention study in humans was conducted with blood samples collected at multiple time points. Using an untargeted metabolomic approach based on HPLC-ESI-QTOF-MS, 66 circulating metabolites were detected, including 9 common to both extracts, such as homovanillic acid sulfate and glucuronide derivates, hydroxytyrosol sulfate, etc. These common metabolites displayed significantly different T max values depending on the source, suggesting distinct metabolization pathways for each extract. The study highlights how shared bioavailable metabolites may underlie similar bioactivities observed between these two plant sources.
doi_str_mv	10.1021/acs.jafc.4c05325
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Agric. Food Chem</addtitle><description>Lippia citriodora and Olea europaea are known for their shared common bioactivities. Although both matrices are rich in similar families of bioactive compounds, their specific phytochemical compounds are mostly different. Since these compounds can be metabolized in the organism, this study hypothesized that common bioavailable metabolites may contribute to their similar bioactive effects. To test this, an acute double-blind intervention study in humans was conducted with blood samples collected at multiple time points. Using an untargeted metabolomic approach based on HPLC-ESI-QTOF-MS, 66 circulating metabolites were detected, including 9 common to both extracts, such as homovanillic acid sulfate and glucuronide derivates, hydroxytyrosol sulfate, etc. These common metabolites displayed significantly different T max values depending on the source, suggesting distinct metabolization pathways for each extract. 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Cádiz-Gurrea, María de la Luz ; Sánchez-Marzo, Noelia ; Barrajón-Catalán, Enrique ; Arráez-Román, David ; Fernández-Ochoa, Álvaro ; Segura-Carretero, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a308t-6c6d8432c12b3d4237fb6395b6873e55a3a1fce8e00da99d3655f0eb6ecb01d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aloysia citrodora</topic><topic>bioavailability</topic><topic>Biological Availability</topic><topic>blood</topic><topic>Chromatography, High Pressure Liquid</topic><topic>clinical trials</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>food chemistry</topic><topic>homovanillic acid</topic><topic>Humans</topic><topic>Lippia - chemistry</topic><topic>Lippia - metabolism</topic><topic>Male</topic><topic>metabolites</topic><topic>Metabolomics</topic><topic>Olea - chemistry</topic><topic>Olea - metabolism</topic><topic>Olea europaea</topic><topic>Omics Technologies Applied to Agriculture and Food</topic><topic>phytochemicals</topic><topic>Plant Extracts - blood</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - metabolism</topic><topic>sulfates</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villegas-Aguilar, María del Carmen</creatorcontrib><creatorcontrib>Cádiz-Gurrea, María de la Luz</creatorcontrib><creatorcontrib>Sánchez-Marzo, Noelia</creatorcontrib><creatorcontrib>Barrajón-Catalán, Enrique</creatorcontrib><creatorcontrib>Arráez-Román, David</creatorcontrib><creatorcontrib>Fernández-Ochoa, Álvaro</creatorcontrib><creatorcontrib>Segura-Carretero, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villegas-Aguilar, María del Carmen</au><au>Cádiz-Gurrea, María de la Luz</au><au>Sánchez-Marzo, Noelia</au><au>Barrajón-Catalán, Enrique</au><au>Arráez-Román, David</au><au>Fernández-Ochoa, Álvaro</au><au>Segura-Carretero, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Application of Untargeted Metabolomic Approaches for the Search of Common Bioavailable Metabolites in Human Plasma Samples from Lippia citriodora and Olea europaea Extracts</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2024-11-06</date><risdate>2024</risdate><volume>72</volume><issue>44</issue><spage>24879</spage><epage>24893</epage><pages>24879-24893</pages><issn>0021-8561</issn><issn>1520-5118</issn><eissn>1520-5118</eissn><abstract>Lippia citriodora and Olea europaea are known for their shared common bioactivities. Although both matrices are rich in similar families of bioactive compounds, their specific phytochemical compounds are mostly different. Since these compounds can be metabolized in the organism, this study hypothesized that common bioavailable metabolites may contribute to their similar bioactive effects. To test this, an acute double-blind intervention study in humans was conducted with blood samples collected at multiple time points. 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subjects	Adult Aloysia citrodora bioavailability Biological Availability blood Chromatography, High Pressure Liquid clinical trials Double-Blind Method Female food chemistry homovanillic acid Humans Lippia - chemistry Lippia - metabolism Male metabolites Metabolomics Olea - chemistry Olea - metabolism Olea europaea Omics Technologies Applied to Agriculture and Food phytochemicals Plant Extracts - blood Plant Extracts - chemistry Plant Extracts - metabolism sulfates Young Adult
title	The Application of Untargeted Metabolomic Approaches for the Search of Common Bioavailable Metabolites in Human Plasma Samples from Lippia citriodora and Olea europaea Extracts
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