Body composition of infants at 6 months of age using a 3-compartment model
Background/Objectives Two compartment (2 C) models of body composition, including Air Displacement Plethysmography (ADP) and Deuterium Dilution (DD), assume constant composition of fat-free mass (FFM), while 3-compartment (3 C) model overcomes some of these assumptions; studies are limited in infant...
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| Veröffentlicht in: | European journal of clinical nutrition 2024-11, Vol.78 (11), p.936-942 |
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| creator | Kuriyan, Rebecca Hills, Andrew P. Murphy-Alford, Alexia Padmanabha, Ramya Nyati, Lukhanyo H. Byrne, Nuala M. Kurpad, Anura V. Norris, Shane |
| description | Background/Objectives
Two compartment (2 C) models of body composition, including Air Displacement Plethysmography (ADP) and Deuterium Dilution (DD), assume constant composition of fat-free mass (FFM), while 3-compartment (3 C) model overcomes some of these assumptions; studies are limited in infants. The objective of the present study is to compare 3 C estimates of body composition in 6-mo. old infants from Australia, India, and South Africa, including FFM density and hydration, compare with published literature and to evaluate agreement of body composition estimates from ADP and DD.
Methods
Body volume and water were measured in 176 healthy infants using ADP and DD. 3C-model estimates of fat mass (FM), FFM and its composition were calculated, compared between countries (age and sex adjusted) and with published literature. Agreement between estimates from ADP and DD were compared by Bland–Altman and correlation analyses.
Results
South African infants had significantly higher % FM (11.5%) and density of FFM compared to Australian infants. Australian infants had significantly higher % FFM (74.7 ± 4.4%) compared to South African infants (71.4 ± 5.0) and higher FFMI (12.7 ± 0.8 kg/m
2
) compared to South African (12.3 ± 1.2 kg/m
2
) and Indian infants (11.9 ± 1.0 kg/m
2
). FFM composition of present study differed significantly from literature. Pooled three country estimates of FM and FFM were comparable between ADP and DD; mean difference of −0.05 (95% CI: −0.64, +0.55) kg and +0.05 (95% CI: −0.55, +0.64) kg.
Conclusions
3C-model estimates of body composition in infants differed between countries; future studies are needed to confirm these findings and investigate causes for the differences. |
| doi_str_mv | 10.1038/s41430-023-01351-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11537952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2877380048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-1ed89025b733d426b84f052cf9a201cdfa0f9da2bfbf8cb4977beda978bb845f3</originalsourceid><addsrcrecordid>eNp9kc1O3DAUha0KVKbAC3RRWWLTjcv1X-ysqoKgBY3EBtaWk9hDUGIPdoLE29fDTCntgpWle757fK4OQp8pfKPA9WkWVHAgwDgByiUl7ANaUKEqIisBe2gBtRSEA6gD9CnnB4AiKvYRHXClOZdVtUDXZ7F7xm0c1zH3Ux8Djh73wdswZWwnXOExhuk-b8Z25fCc-7DCFnOy2bFpGl2YCtO54Qjteztkd7x7D9Hd5cXt-S-yvPl5df5jSVqh5ESo63QNTDaK806wqtHCg2Stry0D2nbegq87yxrfeN02olaqcZ2tlW4KKj0_RN-3vuu5GV3XlgDJDmad-tGmZxNtb_5VQn9vVvHJUCq5qiUrDl93Dik-zi5PZuxz64bBBhfnbJhWimsAoQt68h_6EOcUyn2GUyYYhapWhWJbqk0x5-T8axoKZtOV2XZlSlfmpSuzSfHl7R2vK3_KKQDfArlIYeXS37_fsf0N8zWfYg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3124210697</pqid></control><display><type>article</type><title>Body composition of infants at 6 months of age using a 3-compartment model</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kuriyan, Rebecca ; Hills, Andrew P. ; Murphy-Alford, Alexia ; Padmanabha, Ramya ; Nyati, Lukhanyo H. ; Byrne, Nuala M. ; Kurpad, Anura V. ; Norris, Shane</creator><creatorcontrib>Kuriyan, Rebecca ; Hills, Andrew P. ; Murphy-Alford, Alexia ; Padmanabha, Ramya ; Nyati, Lukhanyo H. ; Byrne, Nuala M. ; Kurpad, Anura V. ; Norris, Shane ; Multi-Center Infant Body Composition Reference Study (MIBCRS)</creatorcontrib><description>Background/Objectives
Two compartment (2 C) models of body composition, including Air Displacement Plethysmography (ADP) and Deuterium Dilution (DD), assume constant composition of fat-free mass (FFM), while 3-compartment (3 C) model overcomes some of these assumptions; studies are limited in infants. The objective of the present study is to compare 3 C estimates of body composition in 6-mo. old infants from Australia, India, and South Africa, including FFM density and hydration, compare with published literature and to evaluate agreement of body composition estimates from ADP and DD.
Methods
Body volume and water were measured in 176 healthy infants using ADP and DD. 3C-model estimates of fat mass (FM), FFM and its composition were calculated, compared between countries (age and sex adjusted) and with published literature. Agreement between estimates from ADP and DD were compared by Bland–Altman and correlation analyses.
Results
South African infants had significantly higher % FM (11.5%) and density of FFM compared to Australian infants. Australian infants had significantly higher % FFM (74.7 ± 4.4%) compared to South African infants (71.4 ± 5.0) and higher FFMI (12.7 ± 0.8 kg/m
2
) compared to South African (12.3 ± 1.2 kg/m
2
) and Indian infants (11.9 ± 1.0 kg/m
2
). FFM composition of present study differed significantly from literature. Pooled three country estimates of FM and FFM were comparable between ADP and DD; mean difference of −0.05 (95% CI: −0.64, +0.55) kg and +0.05 (95% CI: −0.55, +0.64) kg.
Conclusions
3C-model estimates of body composition in infants differed between countries; future studies are needed to confirm these findings and investigate causes for the differences.</description><identifier>ISSN: 0954-3007</identifier><identifier>ISSN: 1476-5640</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-023-01351-2</identifier><identifier>PMID: 37833566</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/700/1720 ; 692/700/2814 ; Adipose Tissue - metabolism ; Australia ; Babies ; Body Composition ; Body fat ; Body measurements ; Body volume (biology) ; Body Water ; Clinical Nutrition ; Correlation analysis ; Deuterium - analysis ; Epidemiology ; Estimates ; Fat-free body mass ; Female ; Humans ; India ; Infant ; Infants ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Models, Biological ; Plethysmography ; Plethysmography - methods ; Public Health ; South Africa</subject><ispartof>European journal of clinical nutrition, 2024-11, Vol.78 (11), p.936-942</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-1ed89025b733d426b84f052cf9a201cdfa0f9da2bfbf8cb4977beda978bb845f3</citedby><cites>FETCH-LOGICAL-c475t-1ed89025b733d426b84f052cf9a201cdfa0f9da2bfbf8cb4977beda978bb845f3</cites><orcidid>0000-0001-7095-3796 ; 0000-0001-7998-2438 ; 0000-0002-3864-574X ; 0000-0003-0975-344X ; 0000-0002-7787-7201 ; 0000-0001-7124-3788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41430-023-01351-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41430-023-01351-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37833566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuriyan, Rebecca</creatorcontrib><creatorcontrib>Hills, Andrew P.</creatorcontrib><creatorcontrib>Murphy-Alford, Alexia</creatorcontrib><creatorcontrib>Padmanabha, Ramya</creatorcontrib><creatorcontrib>Nyati, Lukhanyo H.</creatorcontrib><creatorcontrib>Byrne, Nuala M.</creatorcontrib><creatorcontrib>Kurpad, Anura V.</creatorcontrib><creatorcontrib>Norris, Shane</creatorcontrib><creatorcontrib>Multi-Center Infant Body Composition Reference Study (MIBCRS)</creatorcontrib><title>Body composition of infants at 6 months of age using a 3-compartment model</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives
Two compartment (2 C) models of body composition, including Air Displacement Plethysmography (ADP) and Deuterium Dilution (DD), assume constant composition of fat-free mass (FFM), while 3-compartment (3 C) model overcomes some of these assumptions; studies are limited in infants. The objective of the present study is to compare 3 C estimates of body composition in 6-mo. old infants from Australia, India, and South Africa, including FFM density and hydration, compare with published literature and to evaluate agreement of body composition estimates from ADP and DD.
Methods
Body volume and water were measured in 176 healthy infants using ADP and DD. 3C-model estimates of fat mass (FM), FFM and its composition were calculated, compared between countries (age and sex adjusted) and with published literature. Agreement between estimates from ADP and DD were compared by Bland–Altman and correlation analyses.
Results
South African infants had significantly higher % FM (11.5%) and density of FFM compared to Australian infants. Australian infants had significantly higher % FFM (74.7 ± 4.4%) compared to South African infants (71.4 ± 5.0) and higher FFMI (12.7 ± 0.8 kg/m
2
) compared to South African (12.3 ± 1.2 kg/m
2
) and Indian infants (11.9 ± 1.0 kg/m
2
). FFM composition of present study differed significantly from literature. Pooled three country estimates of FM and FFM were comparable between ADP and DD; mean difference of −0.05 (95% CI: −0.64, +0.55) kg and +0.05 (95% CI: −0.55, +0.64) kg.
Conclusions
3C-model estimates of body composition in infants differed between countries; future studies are needed to confirm these findings and investigate causes for the differences.</description><subject>692/700/1720</subject><subject>692/700/2814</subject><subject>Adipose Tissue - metabolism</subject><subject>Australia</subject><subject>Babies</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Body measurements</subject><subject>Body volume (biology)</subject><subject>Body Water</subject><subject>Clinical Nutrition</subject><subject>Correlation analysis</subject><subject>Deuterium - analysis</subject><subject>Epidemiology</subject><subject>Estimates</subject><subject>Fat-free body mass</subject><subject>Female</subject><subject>Humans</subject><subject>India</subject><subject>Infant</subject><subject>Infants</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Models, Biological</subject><subject>Plethysmography</subject><subject>Plethysmography - methods</subject><subject>Public Health</subject><subject>South Africa</subject><issn>0954-3007</issn><issn>1476-5640</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1O3DAUha0KVKbAC3RRWWLTjcv1X-ysqoKgBY3EBtaWk9hDUGIPdoLE29fDTCntgpWle757fK4OQp8pfKPA9WkWVHAgwDgByiUl7ANaUKEqIisBe2gBtRSEA6gD9CnnB4AiKvYRHXClOZdVtUDXZ7F7xm0c1zH3Ux8Djh73wdswZWwnXOExhuk-b8Z25fCc-7DCFnOy2bFpGl2YCtO54Qjteztkd7x7D9Hd5cXt-S-yvPl5df5jSVqh5ESo63QNTDaK806wqtHCg2Stry0D2nbegq87yxrfeN02olaqcZ2tlW4KKj0_RN-3vuu5GV3XlgDJDmad-tGmZxNtb_5VQn9vVvHJUCq5qiUrDl93Dik-zi5PZuxz64bBBhfnbJhWimsAoQt68h_6EOcUyn2GUyYYhapWhWJbqk0x5-T8axoKZtOV2XZlSlfmpSuzSfHl7R2vK3_KKQDfArlIYeXS37_fsf0N8zWfYg</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Kuriyan, Rebecca</creator><creator>Hills, Andrew P.</creator><creator>Murphy-Alford, Alexia</creator><creator>Padmanabha, Ramya</creator><creator>Nyati, Lukhanyo H.</creator><creator>Byrne, Nuala M.</creator><creator>Kurpad, Anura V.</creator><creator>Norris, Shane</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7095-3796</orcidid><orcidid>https://orcid.org/0000-0001-7998-2438</orcidid><orcidid>https://orcid.org/0000-0002-3864-574X</orcidid><orcidid>https://orcid.org/0000-0003-0975-344X</orcidid><orcidid>https://orcid.org/0000-0002-7787-7201</orcidid><orcidid>https://orcid.org/0000-0001-7124-3788</orcidid></search><sort><creationdate>20241101</creationdate><title>Body composition of infants at 6 months of age using a 3-compartment model</title><author>Kuriyan, Rebecca ; Hills, Andrew P. ; Murphy-Alford, Alexia ; Padmanabha, Ramya ; Nyati, Lukhanyo H. ; Byrne, Nuala M. ; Kurpad, Anura V. ; Norris, Shane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-1ed89025b733d426b84f052cf9a201cdfa0f9da2bfbf8cb4977beda978bb845f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/700/1720</topic><topic>692/700/2814</topic><topic>Adipose Tissue - metabolism</topic><topic>Australia</topic><topic>Babies</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body measurements</topic><topic>Body volume (biology)</topic><topic>Body Water</topic><topic>Clinical Nutrition</topic><topic>Correlation analysis</topic><topic>Deuterium - analysis</topic><topic>Epidemiology</topic><topic>Estimates</topic><topic>Fat-free body mass</topic><topic>Female</topic><topic>Humans</topic><topic>India</topic><topic>Infant</topic><topic>Infants</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Models, Biological</topic><topic>Plethysmography</topic><topic>Plethysmography - methods</topic><topic>Public Health</topic><topic>South Africa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuriyan, Rebecca</creatorcontrib><creatorcontrib>Hills, Andrew P.</creatorcontrib><creatorcontrib>Murphy-Alford, Alexia</creatorcontrib><creatorcontrib>Padmanabha, Ramya</creatorcontrib><creatorcontrib>Nyati, Lukhanyo H.</creatorcontrib><creatorcontrib>Byrne, Nuala M.</creatorcontrib><creatorcontrib>Kurpad, Anura V.</creatorcontrib><creatorcontrib>Norris, Shane</creatorcontrib><creatorcontrib>Multi-Center Infant Body Composition Reference Study (MIBCRS)</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuriyan, Rebecca</au><au>Hills, Andrew P.</au><au>Murphy-Alford, Alexia</au><au>Padmanabha, Ramya</au><au>Nyati, Lukhanyo H.</au><au>Byrne, Nuala M.</au><au>Kurpad, Anura V.</au><au>Norris, Shane</au><aucorp>Multi-Center Infant Body Composition Reference Study (MIBCRS)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body composition of infants at 6 months of age using a 3-compartment model</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>78</volume><issue>11</issue><spage>936</spage><epage>942</epage><pages>936-942</pages><issn>0954-3007</issn><issn>1476-5640</issn><eissn>1476-5640</eissn><abstract>Background/Objectives
Two compartment (2 C) models of body composition, including Air Displacement Plethysmography (ADP) and Deuterium Dilution (DD), assume constant composition of fat-free mass (FFM), while 3-compartment (3 C) model overcomes some of these assumptions; studies are limited in infants. The objective of the present study is to compare 3 C estimates of body composition in 6-mo. old infants from Australia, India, and South Africa, including FFM density and hydration, compare with published literature and to evaluate agreement of body composition estimates from ADP and DD.
Methods
Body volume and water were measured in 176 healthy infants using ADP and DD. 3C-model estimates of fat mass (FM), FFM and its composition were calculated, compared between countries (age and sex adjusted) and with published literature. Agreement between estimates from ADP and DD were compared by Bland–Altman and correlation analyses.
Results
South African infants had significantly higher % FM (11.5%) and density of FFM compared to Australian infants. Australian infants had significantly higher % FFM (74.7 ± 4.4%) compared to South African infants (71.4 ± 5.0) and higher FFMI (12.7 ± 0.8 kg/m
2
) compared to South African (12.3 ± 1.2 kg/m
2
) and Indian infants (11.9 ± 1.0 kg/m
2
). FFM composition of present study differed significantly from literature. Pooled three country estimates of FM and FFM were comparable between ADP and DD; mean difference of −0.05 (95% CI: −0.64, +0.55) kg and +0.05 (95% CI: −0.55, +0.64) kg.
Conclusions
3C-model estimates of body composition in infants differed between countries; future studies are needed to confirm these findings and investigate causes for the differences.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37833566</pmid><doi>10.1038/s41430-023-01351-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7095-3796</orcidid><orcidid>https://orcid.org/0000-0001-7998-2438</orcidid><orcidid>https://orcid.org/0000-0002-3864-574X</orcidid><orcidid>https://orcid.org/0000-0003-0975-344X</orcidid><orcidid>https://orcid.org/0000-0002-7787-7201</orcidid><orcidid>https://orcid.org/0000-0001-7124-3788</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2024-11, Vol.78 (11), p.936-942 |
| issn | 0954-3007 1476-5640 1476-5640 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11537952 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 692/700/1720 692/700/2814 Adipose Tissue - metabolism Australia Babies Body Composition Body fat Body measurements Body volume (biology) Body Water Clinical Nutrition Correlation analysis Deuterium - analysis Epidemiology Estimates Fat-free body mass Female Humans India Infant Infants Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Models, Biological Plethysmography Plethysmography - methods Public Health South Africa |
| title | Body composition of infants at 6 months of age using a 3-compartment model |
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