Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding

Complement activation through antibody-antigen complexes is crucial in various pathophysiological processes and utilized in immunotherapies to eliminate infectious agents, regulatory immune cells, or cancer cells. The tertiary structures of the four IgG antibody subclasses are largely comparable, wi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-10, Vol.121 (44), p.e2406192121
Hauptverfasser:	Frischauf, Nikolaus, Strasser, Jürgen, Borg, Ellen G F, Labrijn, Aran F, Beurskens, Frank J, Preiner, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigen-Antibody Complex - chemistry Antigen-Antibody Complex - immunology Antigen-Antibody Complex - metabolism Antigens Antigens - immunology Antigens - metabolism Atomic force microscopy Binding Biological Sciences Cell activation Cell Line, Tumor Complement Complement activation Complement Activation - immunology Complement C1 - immunology Complement C1 - metabolism Complement component C1 Flexibility Force distribution Humans IgG antibody Immune system Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunotherapy Lysis Microscopy, Atomic Force Oligomerization Oligomers Protein Binding Protein Multimerization Quartz crystal microbalance Quartz crystals Rate constants Real time Tumor cell lines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!