Chromatin lysine acylation: On the path to chromatin homeostasis and genome integrity

The fundamental role of cells in safeguarding the genome's integrity against DNA double‐strand breaks (DSBs) is crucial for maintaining chromatin homeostasis and the overall genomic stability. Aberrant responses to DNA damage, known as DNA damage responses (DDRs), can result in genomic instabil...

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Veröffentlicht in:	Cancer science 2024-11, Vol.115 (11), p.3506-3519
Hauptverfasser:	Chen, Feng, He, Xingkai, Xu, Wenchao, Zhou, Linmin, Liu, Qi, Chen, Weicheng, Zhu, Wei‐Guo, Zhang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acylation Animals Cell cycle Chromatin Chromatin - metabolism chromatin homeostasis Dehydrogenases DNA Breaks, Double-Stranded DNA Damage DNA damage response DNA Repair Drug resistance Enzymes genome integrity Genomes Genomic Instability Histones - metabolism Homeostasis Humans Kinases Lysine Lysine - metabolism lysine acylation Metabolism modification enzymes Phosphorylation Protein Processing, Post-Translational Proteins Review Therapeutic targets Tumorigenesis Yeast
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