A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma

Although the fecal immunochemical test for hemoglobin (FIT) is a widely used screening test for colorectal cancer, it is not sensitive enough to detect advanced colorectal adenoma. To address this issue, we performed this study to investigate whether combining the FIT and fecal DNA testing of methyl...

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Veröffentlicht in:	Cancer science 2024-11, Vol.115 (11), p.3682-3694
Hauptverfasser:	Inoue, Yukari, Ishiguro, Akiyo, Suehiro, Yutaka, Kunimune, Yuki, Yamaoka, Yuko, Hashimoto, Shinichi, Nakamura, Katsuhiko, Goto, Atsushi, Hamabe, Koichi, Matsumoto, Toshihiko, Tomochika, Shinobu, Higaki, Shingo, Fujii, Ikuei, Suzuki, Chieko, Koga, Michiko, Tsutsumi, Takeya, Lim, Lay Ahyoung, Matsubara, Yasuo, Yotsuyanagi, Hiroshi, Nagano, Hiroaki, Yamamoto, Naoki, Sakaida, Isao, Takami, Taro, Nishioka, Mitsuaki, Yamasaki, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Adenoma - diagnosis Adult advanced colorectal adenoma Age Factors Aged Aged, 80 and over Biomarkers, Tumor - analysis Colonoscopy Colonoscopy - methods Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis DNA Methylation Early Detection of Cancer - methods Enzymes fecal DNA test fecal immunochemical test for hemoglobin Feces Feces - chemistry Female Genetic screening Genetic testing Hemoglobin Hemoglobins - analysis Humans Male Medical laboratories methylation Middle Aged Multivariate analysis Occult Blood Original ORIGINAL ARTICLE Patients Regression analysis Sensitivity analysis Sensitivity and Specificity Software Somatostatin Somatostatin - analysis SST Telomerase Tumors
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