Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion

Background Lymphocyte antigen 6 complex, locus E (Ly6E) has been initially demonstrated to involve in T cell activity and impair viral infectivity. Recently, high expression levels of Ly6E have been reported in tumor microenvironment (TME) of various types of cancers. However, the immunoregulatory m...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy : CII Immunotherapy : CII, 2024-11, Vol.74 (1), p.4, Article 4
Hauptverfasser:	Hailin, Lan, Yiting, Chen, Yue, Wu, Lijun, Li, Renlu, Zhang, Yunhan, Chen, Yanyang, Zhu, Qiuyu, Zhang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigens, Ly - immunology Antigens, Ly - metabolism Antigens, Surface Breast cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - pathology Cancer Cancer immunotherapy Cancer Research CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell culture Cell Line, Tumor Cell Proliferation Cell survival Culture media Female Flow cytometry GPI-Linked Proteins Humans Immunological memory Immunology Immunoregulation Immunotherapy Infectivity Infiltration Leukocyte migration Long term memory Lymphocytes Lymphocytes T Macrophages Medicine Medicine & Public Health Memory cells Metastases Mice Mice, Inbred C57BL Mice, Knockout Oncology Tumor cell lines Tumor cells Tumor microenvironment Tumor Microenvironment - immunology Tumors
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