Knee Pain, Joint Loading, and Structural Abnormalities on MRI in 13-Year-Old Children in a Population-Based Birth Cohort
Background: Knee pain is a common problem in children and adolescents, and it often has a chronic character. Purpose: To examine the prevalence of knee pain in 13-year-old children and assess associations of knee pain with physical factors and the presence of structural abnormalities on magnetic res...
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| Veröffentlicht in: | The American journal of sports medicine 2024-10, Vol.52 (12), p.3046-3053 |
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| creator | van Leeuwen, Guido J. Kemmeren, Laura A.M. Piscaer, Tom M. Oei, Edwin H.G. Bindels, Patrick J.E. Bierma-Zeinstra, Sita M.A. van Middelkoop, Marienke |
| description | Background:
Knee pain is a common problem in children and adolescents, and it often has a chronic character.
Purpose:
To examine the prevalence of knee pain in 13-year-old children and assess associations of knee pain with physical factors and the presence of structural abnormalities on magnetic resonance imaging (MRI).
Study Design:
Cross-sectional study; Level of evidence, 3.
Methods:
Data from the Generation R Study, a population-based birth cohort, were used. Prevalence and characteristics of knee pain were assessed, using a pain mannequin, in children 13 years of age (N = 1849). Patient characteristics and data on physical activity were extracted from questionnaires. The body mass index standard deviation score and waist-hip ratio were calculated from objectively measured weight and height. Structural abnormalities were assessed by MRI. The differences between children with and without knee pain were also analyzed.
Results:
A prevalence of 8.0% was found for knee pain in children, of which 92.3% persisted for >3 months (ie, chronic); 37.5% of the children experienced pain daily, and the pain was almost always located on the anterior side of the knee (98.6%). Higher body mass index standard deviation scores were seen in children with knee pain than in the children without knee pain. No differences in physical activity were seen between children with and without knee pain. Moreover, in children with knee pain compared with children without knee pain, characteristics of Osgood-Schlatter disease (6.8% vs 1.9%) and bipartite patella type 3 (4.7% vs 0.3%) were more often seen on MRI.
Conclusion:
This study shows that knee pain is a relatively frequent problem in children. It is almost always located on the anterior aspect, has a chronic character, and is often experienced daily. However, the possible implication of structural abnormalities on MRI in children with knee pain and the possible relationship with the development of future knee complaints are still unclear. |
| doi_str_mv | 10.1177/03635465241274792 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11529129</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_03635465241274792</sage_id><sourcerecordid>3119233908</sourcerecordid><originalsourceid>FETCH-LOGICAL-c306t-e392eb4037bb8216e75adceaf3e2a938493474135507acc97e33d0e46e66fd413</originalsourceid><addsrcrecordid>eNp1kUtvEzEUhS1ERUPhB7BBltiw6LS2r2ccr1AbUWgb1IrHgpXlmblJXE3s1Pag8u9xlFJeYmXJ5zvH9_gS8oKzI86VOmbQQC2bWkgulFRaPCITXteiAmjqx2Sy1astsE-epnTDGOOqmT4h-6BBMCn0hNxdekR6bZ0_pBfB-UznwfbOLw-p9T39lOPY5THagZ60PsS1HVx2mGjw9MPHc-o85VB9RRurq6Gns5Ub-oh-e2_pddiMg80u-OrUJuzpqYt5RWdhFWJ-RvYWdkj4_P48IF_O3n6eva_mV-_OZyfzqgPW5ApBC2wlA9W2U8EbVLXtO7QLQGE1TKUGqSSHumbKdp1WCNAzlA02zaIvwgF5s8vdjO0ai9Xn0sZsolvb-N0E68yfincrswzfDOe10FzokvD6PiGG2xFTNmuXOhwG6zGMyQBnuvylVFDQV3-hN2GMvvQrFNcCQLNpofiO6mJIKeLiYRrOzHax5p_FFs_L32s8OH5usgBHOyDZJf569v-JPwBY4amx</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3119233908</pqid></control><display><type>article</type><title>Knee Pain, Joint Loading, and Structural Abnormalities on MRI in 13-Year-Old Children in a Population-Based Birth Cohort</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>van Leeuwen, Guido J. ; Kemmeren, Laura A.M. ; Piscaer, Tom M. ; Oei, Edwin H.G. ; Bindels, Patrick J.E. ; Bierma-Zeinstra, Sita M.A. ; van Middelkoop, Marienke</creator><creatorcontrib>van Leeuwen, Guido J. ; Kemmeren, Laura A.M. ; Piscaer, Tom M. ; Oei, Edwin H.G. ; Bindels, Patrick J.E. ; Bierma-Zeinstra, Sita M.A. ; van Middelkoop, Marienke</creatorcontrib><description>Background:
Knee pain is a common problem in children and adolescents, and it often has a chronic character.
Purpose:
To examine the prevalence of knee pain in 13-year-old children and assess associations of knee pain with physical factors and the presence of structural abnormalities on magnetic resonance imaging (MRI).
Study Design:
Cross-sectional study; Level of evidence, 3.
Methods:
Data from the Generation R Study, a population-based birth cohort, were used. Prevalence and characteristics of knee pain were assessed, using a pain mannequin, in children 13 years of age (N = 1849). Patient characteristics and data on physical activity were extracted from questionnaires. The body mass index standard deviation score and waist-hip ratio were calculated from objectively measured weight and height. Structural abnormalities were assessed by MRI. The differences between children with and without knee pain were also analyzed.
Results:
A prevalence of 8.0% was found for knee pain in children, of which 92.3% persisted for >3 months (ie, chronic); 37.5% of the children experienced pain daily, and the pain was almost always located on the anterior side of the knee (98.6%). Higher body mass index standard deviation scores were seen in children with knee pain than in the children without knee pain. No differences in physical activity were seen between children with and without knee pain. Moreover, in children with knee pain compared with children without knee pain, characteristics of Osgood-Schlatter disease (6.8% vs 1.9%) and bipartite patella type 3 (4.7% vs 0.3%) were more often seen on MRI.
Conclusion:
This study shows that knee pain is a relatively frequent problem in children. It is almost always located on the anterior aspect, has a chronic character, and is often experienced daily. However, the possible implication of structural abnormalities on MRI in children with knee pain and the possible relationship with the development of future knee complaints are still unclear.</description><identifier>ISSN: 0363-5465</identifier><identifier>ISSN: 1552-3365</identifier><identifier>EISSN: 1552-3365</identifier><identifier>DOI: 10.1177/03635465241274792</identifier><identifier>PMID: 39320429</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Arthralgia - diagnostic imaging ; Arthralgia - epidemiology ; Birth Cohort ; Body Mass Index ; Cross-Sectional Studies ; Exercise ; Female ; Humans ; Knee ; Knee Joint - diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Pain ; Prevalence ; Weight-Bearing</subject><ispartof>The American journal of sports medicine, 2024-10, Vol.52 (12), p.3046-3053</ispartof><rights>2024 The Author(s)</rights><rights>2024 The Author(s) 2024 American Orthopaedic Society for Sports Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c306t-e392eb4037bb8216e75adceaf3e2a938493474135507acc97e33d0e46e66fd413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03635465241274792$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03635465241274792$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39320429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Leeuwen, Guido J.</creatorcontrib><creatorcontrib>Kemmeren, Laura A.M.</creatorcontrib><creatorcontrib>Piscaer, Tom M.</creatorcontrib><creatorcontrib>Oei, Edwin H.G.</creatorcontrib><creatorcontrib>Bindels, Patrick J.E.</creatorcontrib><creatorcontrib>Bierma-Zeinstra, Sita M.A.</creatorcontrib><creatorcontrib>van Middelkoop, Marienke</creatorcontrib><title>Knee Pain, Joint Loading, and Structural Abnormalities on MRI in 13-Year-Old Children in a Population-Based Birth Cohort</title><title>The American journal of sports medicine</title><addtitle>Am J Sports Med</addtitle><description>Background:
Knee pain is a common problem in children and adolescents, and it often has a chronic character.
Purpose:
To examine the prevalence of knee pain in 13-year-old children and assess associations of knee pain with physical factors and the presence of structural abnormalities on magnetic resonance imaging (MRI).
Study Design:
Cross-sectional study; Level of evidence, 3.
Methods:
Data from the Generation R Study, a population-based birth cohort, were used. Prevalence and characteristics of knee pain were assessed, using a pain mannequin, in children 13 years of age (N = 1849). Patient characteristics and data on physical activity were extracted from questionnaires. The body mass index standard deviation score and waist-hip ratio were calculated from objectively measured weight and height. Structural abnormalities were assessed by MRI. The differences between children with and without knee pain were also analyzed.
Results:
A prevalence of 8.0% was found for knee pain in children, of which 92.3% persisted for >3 months (ie, chronic); 37.5% of the children experienced pain daily, and the pain was almost always located on the anterior side of the knee (98.6%). Higher body mass index standard deviation scores were seen in children with knee pain than in the children without knee pain. No differences in physical activity were seen between children with and without knee pain. Moreover, in children with knee pain compared with children without knee pain, characteristics of Osgood-Schlatter disease (6.8% vs 1.9%) and bipartite patella type 3 (4.7% vs 0.3%) were more often seen on MRI.
Conclusion:
This study shows that knee pain is a relatively frequent problem in children. It is almost always located on the anterior aspect, has a chronic character, and is often experienced daily. However, the possible implication of structural abnormalities on MRI in children with knee pain and the possible relationship with the development of future knee complaints are still unclear.</description><subject>Adolescent</subject><subject>Arthralgia - diagnostic imaging</subject><subject>Arthralgia - epidemiology</subject><subject>Birth Cohort</subject><subject>Body Mass Index</subject><subject>Cross-Sectional Studies</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Knee</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Pain</subject><subject>Prevalence</subject><subject>Weight-Bearing</subject><issn>0363-5465</issn><issn>1552-3365</issn><issn>1552-3365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp1kUtvEzEUhS1ERUPhB7BBltiw6LS2r2ccr1AbUWgb1IrHgpXlmblJXE3s1Pag8u9xlFJeYmXJ5zvH9_gS8oKzI86VOmbQQC2bWkgulFRaPCITXteiAmjqx2Sy1astsE-epnTDGOOqmT4h-6BBMCn0hNxdekR6bZ0_pBfB-UznwfbOLw-p9T39lOPY5THagZ60PsS1HVx2mGjw9MPHc-o85VB9RRurq6Gns5Ub-oh-e2_pddiMg80u-OrUJuzpqYt5RWdhFWJ-RvYWdkj4_P48IF_O3n6eva_mV-_OZyfzqgPW5ApBC2wlA9W2U8EbVLXtO7QLQGE1TKUGqSSHumbKdp1WCNAzlA02zaIvwgF5s8vdjO0ai9Xn0sZsolvb-N0E68yfincrswzfDOe10FzokvD6PiGG2xFTNmuXOhwG6zGMyQBnuvylVFDQV3-hN2GMvvQrFNcCQLNpofiO6mJIKeLiYRrOzHax5p_FFs_L32s8OH5usgBHOyDZJf569v-JPwBY4amx</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>van Leeuwen, Guido J.</creator><creator>Kemmeren, Laura A.M.</creator><creator>Piscaer, Tom M.</creator><creator>Oei, Edwin H.G.</creator><creator>Bindels, Patrick J.E.</creator><creator>Bierma-Zeinstra, Sita M.A.</creator><creator>van Middelkoop, Marienke</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202410</creationdate><title>Knee Pain, Joint Loading, and Structural Abnormalities on MRI in 13-Year-Old Children in a Population-Based Birth Cohort</title><author>van Leeuwen, Guido J. ; Kemmeren, Laura A.M. ; Piscaer, Tom M. ; Oei, Edwin H.G. ; Bindels, Patrick J.E. ; Bierma-Zeinstra, Sita M.A. ; van Middelkoop, Marienke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-e392eb4037bb8216e75adceaf3e2a938493474135507acc97e33d0e46e66fd413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Arthralgia - diagnostic imaging</topic><topic>Arthralgia - epidemiology</topic><topic>Birth Cohort</topic><topic>Body Mass Index</topic><topic>Cross-Sectional Studies</topic><topic>Exercise</topic><topic>Female</topic><topic>Humans</topic><topic>Knee</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Pain</topic><topic>Prevalence</topic><topic>Weight-Bearing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Leeuwen, Guido J.</creatorcontrib><creatorcontrib>Kemmeren, Laura A.M.</creatorcontrib><creatorcontrib>Piscaer, Tom M.</creatorcontrib><creatorcontrib>Oei, Edwin H.G.</creatorcontrib><creatorcontrib>Bindels, Patrick J.E.</creatorcontrib><creatorcontrib>Bierma-Zeinstra, Sita M.A.</creatorcontrib><creatorcontrib>van Middelkoop, Marienke</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of sports medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Leeuwen, Guido J.</au><au>Kemmeren, Laura A.M.</au><au>Piscaer, Tom M.</au><au>Oei, Edwin H.G.</au><au>Bindels, Patrick J.E.</au><au>Bierma-Zeinstra, Sita M.A.</au><au>van Middelkoop, Marienke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Knee Pain, Joint Loading, and Structural Abnormalities on MRI in 13-Year-Old Children in a Population-Based Birth Cohort</atitle><jtitle>The American journal of sports medicine</jtitle><addtitle>Am J Sports Med</addtitle><date>2024-10</date><risdate>2024</risdate><volume>52</volume><issue>12</issue><spage>3046</spage><epage>3053</epage><pages>3046-3053</pages><issn>0363-5465</issn><issn>1552-3365</issn><eissn>1552-3365</eissn><abstract>Background:
Knee pain is a common problem in children and adolescents, and it often has a chronic character.
Purpose:
To examine the prevalence of knee pain in 13-year-old children and assess associations of knee pain with physical factors and the presence of structural abnormalities on magnetic resonance imaging (MRI).
Study Design:
Cross-sectional study; Level of evidence, 3.
Methods:
Data from the Generation R Study, a population-based birth cohort, were used. Prevalence and characteristics of knee pain were assessed, using a pain mannequin, in children 13 years of age (N = 1849). Patient characteristics and data on physical activity were extracted from questionnaires. The body mass index standard deviation score and waist-hip ratio were calculated from objectively measured weight and height. Structural abnormalities were assessed by MRI. The differences between children with and without knee pain were also analyzed.
Results:
A prevalence of 8.0% was found for knee pain in children, of which 92.3% persisted for >3 months (ie, chronic); 37.5% of the children experienced pain daily, and the pain was almost always located on the anterior side of the knee (98.6%). Higher body mass index standard deviation scores were seen in children with knee pain than in the children without knee pain. No differences in physical activity were seen between children with and without knee pain. Moreover, in children with knee pain compared with children without knee pain, characteristics of Osgood-Schlatter disease (6.8% vs 1.9%) and bipartite patella type 3 (4.7% vs 0.3%) were more often seen on MRI.
Conclusion:
This study shows that knee pain is a relatively frequent problem in children. It is almost always located on the anterior aspect, has a chronic character, and is often experienced daily. However, the possible implication of structural abnormalities on MRI in children with knee pain and the possible relationship with the development of future knee complaints are still unclear.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>39320429</pmid><doi>10.1177/03635465241274792</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | SAGE Complete A-Z List; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Arthralgia - diagnostic imaging Arthralgia - epidemiology Birth Cohort Body Mass Index Cross-Sectional Studies Exercise Female Humans Knee Knee Joint - diagnostic imaging Magnetic Resonance Imaging Male Pain Prevalence Weight-Bearing |
| title | Knee Pain, Joint Loading, and Structural Abnormalities on MRI in 13-Year-Old Children in a Population-Based Birth Cohort |
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