Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction

Extracellular matrix protein 1 (ECM1) can inhibit TGFβ activation, but its antifibrotic action remains largely unknown. This study aims to investigate ECM1 function and its physical interaction with the profibrotic connective tissue growth factor (CTGF) in fibrosis and ductular reaction (DR). Ecm1 k...

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Veröffentlicht in:	Hepatology communications 2024-11, Vol.8 (11)
Hauptverfasser:	Sun, Chunbao, Fan, Weiguo, Basha, Sreenivasulu, Tian, Tian, Jin-Smith, Brady, Barkin, Joshua, Xie, Hanhui, Zhou, Junmei, Yin, Xiao-Ming, Ling, Chen, Sun, Bing, Petersen, Bryon, Pi, Liya
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylisothiocyanate Animals Cholestasis - metabolism Cholestasis - pathology Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism Disease Models, Animal Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Humans Liver - metabolism Liver - pathology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Mice Mice, Knockout Original Pyridines - pharmacology Transforming Growth Factor beta - metabolism
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