Tanshinol ameliorates imiquimod-induced psoriasis by inhibiting M1 macrophage polarization through suppression of the notch signaling pathway

Background Psoriasis is a common immune-related chronic inflammatory skin disease, often accompanied by significant itching, and once diseased, the course of the disease lasts for most of the lifetime. Tanshinol (TAN) is an active ingredient of Salvia miltiorrhiza , which possesses pharmacological e...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-11, Vol.397 (11), p.8745-8758
Hauptverfasser:	Liu, Junhao, Yong, Shuangshuang, Yin, Sisi, Feng, Jinhong, Lian, Caihua, Chen, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell activation Cytokines Imiquimod Immune clearance Macrophages Neurosciences Pharmacology/Toxicology Phenotypes Polarization Psoriasis Signal transduction Skin diseases Skin lesions
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