USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis

The aim of this study is to explore the function of USP14 on the sensitivity of retinoblastoma (RB) to cisplatin (DDP) and the underlying mechanism. USP14 was knockdown in Y79 cells by transfecting three siRNAs (si-USP14-1, si-USP14-2, and si-USP14-3), with si-USP14 NC as the negative control. si-US...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-11, Vol.397 (11), p.8671-8680
Hauptverfasser:	Liu, Han, Gan, Qiang, Lai, Yongping, Pan, Zhenhui, Jin, Qifang, Li, Jiayue, Wang, Nanye, Jiao, Shoufeng, Chai, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomedical and Life Sciences Biomedicine Cell cycle Cholecystokinin Cisplatin Cyclooxygenase-2 ERCC1 protein Ferroptosis Flow cytometry G1 phase Lipid metabolism Neurosciences Pharmacology/Toxicology Proteins Retinoblastoma S phase siRNA Survivin Western blotting
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