Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat

The requirement for carnitine and the malonyl-CoA sensitivity of carnitine palmitoyl-transferase I (EC 2.3.1.21) were measured in isolated mitochondria from eight tissues of animal or human origin using fixed concentrations of palmitoyl-CoA (50 microM) and albumin (147 microM). The Km for carnitine...

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Veröffentlicht in:	Biochemical journal 1983-07, Vol.214 (1), p.21-28
Hauptverfasser:	McGarry, J D, Mills, S E, Long, C S, Foster, D W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - pharmacology Acyltransferases - metabolism Animals carnitine Carnitine - metabolism Carnitine O-Palmitoyltransferase - antagonists & inhibitors Carnitine O-Palmitoyltransferase - metabolism carnitine palmitoyltransferase Dogs Female Guinea Pigs Humans In Vitro Techniques Kinetics Liver - enzymology Male Malonyl Coenzyme A - pharmacology malonyl-CoA man mitochondria Mitochondria - enzymology Muscles - enzymology Myocardium - enzymology Palmitoyl Coenzyme A - pharmacology Rats Rats, Inbred Strains Starvation - enzymology
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