Diospyros kaki fruit extract produces antiarthritic and antinociceptive effects in rats with complete Freund's adjuvant‐induced arthritis
Current treatments for rheumatoid arthritis produce untoward effects; thus, considerable effort has been made to recognize effective herbal medicines against the condition. In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's ad...
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| creator | Forouzanfar, Fatemeh Mirdoosti, Motahareh Akaberi, Maryam Rezaee, Ramin Esmaeili, Seyed‐Alireza Saburi, Ehsan Mahaki, Hanie |
| description | Current treatments for rheumatoid arthritis produce untoward effects; thus, considerable effort has been made to recognize effective herbal medicines against the condition. In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's adjuvant (CFA)‐induced arthritis in rats was investigated. The extract was characterized using liquid chromatography–electrospray mass spectrometry (LC‐ESIMS). Male Wistar rats were grouped as follows (eight rats in each): control, CFA, CFA + indomethacin (5 mg/kg), CFA + DFHE (50 mg/kg), and CFA + DFHE (100 mg/kg). Paw volume, mechanical allodynia, thermal hyperalgesia, and arthritis score were evaluated. Serum levels of malondialdehyde (MDA), thiol groups, tumor necrosis factor‐alpha (TNF‐α), as well as glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were evaluated. Carotenoids were found to be the major components of DFHE. Administration of DFHE (100 mg/kg) significantly decreased arthritis score, paw volume, and thermal hyperalgesia, and improved mechanical allodynia. MDA and TNF‐α levels were decreased while thiol levels and SOD and GPx activities were increased in DFHE‐treated groups compared to the CFA group. These results suggest that D. kaki extract caused an improvement in clinical signs of rheumatoid arthritis symptoms possibly through suppression of oxidative stress and inflammation.
Diospyros kaki fruit hydroalcoholic extract reduced arthritis score and pain and alleviated inflammation and oxidative stress status. |
| doi_str_mv | 10.1002/fsn3.4418 |
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Diospyros kaki fruit hydroalcoholic extract reduced arthritis score and pain and alleviated inflammation and oxidative stress status.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.4418</identifier><identifier>PMID: 39479654</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adjuvants ; Animals ; Arthritis ; Autoimmune diseases ; Carotenoids ; Chromatography ; Diospyros kaki ; Disease ; Drug dosages ; Erythema ; Free radicals ; Freund's adjuvant ; Fruits ; Glutathione ; Glutathione peroxidase ; Herbal medicine ; Hyperalgesia ; Illnesses ; Indomethacin ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; mechanical allodynia ; natural products ; Original ; Oxidative stress ; Pain perception ; Peroxidase ; persimmon ; Rheumatoid arthritis ; Serum levels ; Solvents ; Superoxide dismutase ; thermal hyperalgesia ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Variance analysis</subject><ispartof>Food science & nutrition, 2024-10, Vol.12 (10), p.8084-8092</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3348-69916edcceea9ac20e8875485bde69ca7a1847a2708bc541bf99b5ed6d097efe3</cites><orcidid>0000-0003-0023-6470</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521739/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521739/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11543,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39479654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forouzanfar, Fatemeh</creatorcontrib><creatorcontrib>Mirdoosti, Motahareh</creatorcontrib><creatorcontrib>Akaberi, Maryam</creatorcontrib><creatorcontrib>Rezaee, Ramin</creatorcontrib><creatorcontrib>Esmaeili, Seyed‐Alireza</creatorcontrib><creatorcontrib>Saburi, Ehsan</creatorcontrib><creatorcontrib>Mahaki, Hanie</creatorcontrib><title>Diospyros kaki fruit extract produces antiarthritic and antinociceptive effects in rats with complete Freund's adjuvant‐induced arthritis</title><title>Food science & nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Current treatments for rheumatoid arthritis produce untoward effects; thus, considerable effort has been made to recognize effective herbal medicines against the condition. In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's adjuvant (CFA)‐induced arthritis in rats was investigated. The extract was characterized using liquid chromatography–electrospray mass spectrometry (LC‐ESIMS). Male Wistar rats were grouped as follows (eight rats in each): control, CFA, CFA + indomethacin (5 mg/kg), CFA + DFHE (50 mg/kg), and CFA + DFHE (100 mg/kg). Paw volume, mechanical allodynia, thermal hyperalgesia, and arthritis score were evaluated. Serum levels of malondialdehyde (MDA), thiol groups, tumor necrosis factor‐alpha (TNF‐α), as well as glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were evaluated. Carotenoids were found to be the major components of DFHE. Administration of DFHE (100 mg/kg) significantly decreased arthritis score, paw volume, and thermal hyperalgesia, and improved mechanical allodynia. MDA and TNF‐α levels were decreased while thiol levels and SOD and GPx activities were increased in DFHE‐treated groups compared to the CFA group. These results suggest that D. kaki extract caused an improvement in clinical signs of rheumatoid arthritis symptoms possibly through suppression of oxidative stress and inflammation.
Diospyros kaki fruit hydroalcoholic extract reduced arthritis score and pain and alleviated inflammation and oxidative stress status.</description><subject>Adjuvants</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Autoimmune diseases</subject><subject>Carotenoids</subject><subject>Chromatography</subject><subject>Diospyros kaki</subject><subject>Disease</subject><subject>Drug dosages</subject><subject>Erythema</subject><subject>Free radicals</subject><subject>Freund's adjuvant</subject><subject>Fruits</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Herbal medicine</subject><subject>Hyperalgesia</subject><subject>Illnesses</subject><subject>Indomethacin</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>mechanical allodynia</subject><subject>natural products</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Pain perception</subject><subject>Peroxidase</subject><subject>persimmon</subject><subject>Rheumatoid arthritis</subject><subject>Serum levels</subject><subject>Solvents</subject><subject>Superoxide dismutase</subject><subject>thermal hyperalgesia</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-TNF</subject><subject>Variance 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fruit extract produces antiarthritic and antinociceptive effects in rats with complete Freund's adjuvant‐induced arthritis</title><author>Forouzanfar, Fatemeh ; Mirdoosti, Motahareh ; Akaberi, Maryam ; Rezaee, Ramin ; Esmaeili, Seyed‐Alireza ; Saburi, Ehsan ; Mahaki, Hanie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3348-69916edcceea9ac20e8875485bde69ca7a1847a2708bc541bf99b5ed6d097efe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adjuvants</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Autoimmune diseases</topic><topic>Carotenoids</topic><topic>Chromatography</topic><topic>Diospyros kaki</topic><topic>Disease</topic><topic>Drug dosages</topic><topic>Erythema</topic><topic>Free radicals</topic><topic>Freund's adjuvant</topic><topic>Fruits</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Herbal 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Hanie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diospyros kaki fruit extract produces antiarthritic and antinociceptive effects in rats with complete Freund's adjuvant‐induced arthritis</atitle><jtitle>Food science & nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2024-10</date><risdate>2024</risdate><volume>12</volume><issue>10</issue><spage>8084</spage><epage>8092</epage><pages>8084-8092</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>Current treatments for rheumatoid arthritis produce untoward effects; thus, considerable effort has been made to recognize effective herbal medicines against the condition. In the present study, the therapeutic effect of Diospyros kaki fruit hydroalcoholic extract (DFHE) on complete Freund's adjuvant (CFA)‐induced arthritis in rats was investigated. The extract was characterized using liquid chromatography–electrospray mass spectrometry (LC‐ESIMS). Male Wistar rats were grouped as follows (eight rats in each): control, CFA, CFA + indomethacin (5 mg/kg), CFA + DFHE (50 mg/kg), and CFA + DFHE (100 mg/kg). Paw volume, mechanical allodynia, thermal hyperalgesia, and arthritis score were evaluated. Serum levels of malondialdehyde (MDA), thiol groups, tumor necrosis factor‐alpha (TNF‐α), as well as glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were evaluated. Carotenoids were found to be the major components of DFHE. Administration of DFHE (100 mg/kg) significantly decreased arthritis score, paw volume, and thermal hyperalgesia, and improved mechanical allodynia. MDA and TNF‐α levels were decreased while thiol levels and SOD and GPx activities were increased in DFHE‐treated groups compared to the CFA group. These results suggest that D. kaki extract caused an improvement in clinical signs of rheumatoid arthritis symptoms possibly through suppression of oxidative stress and inflammation.
Diospyros kaki fruit hydroalcoholic extract reduced arthritis score and pain and alleviated inflammation and oxidative stress status.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>39479654</pmid><doi>10.1002/fsn3.4418</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0023-6470</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adjuvants Animals Arthritis Autoimmune diseases Carotenoids Chromatography Diospyros kaki Disease Drug dosages Erythema Free radicals Freund's adjuvant Fruits Glutathione Glutathione peroxidase Herbal medicine Hyperalgesia Illnesses Indomethacin Liquid chromatography Mass spectrometry Mass spectroscopy mechanical allodynia natural products Original Oxidative stress Pain perception Peroxidase persimmon Rheumatoid arthritis Serum levels Solvents Superoxide dismutase thermal hyperalgesia Tumor necrosis factor Tumor necrosis factor-TNF Variance analysis |
| title | Diospyros kaki fruit extract produces antiarthritic and antinociceptive effects in rats with complete Freund's adjuvant‐induced arthritis |
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