Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A
Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to...
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| creator | Ogwoni, H. A. Aja, P. M. Eze, Ejike Daniel Agu, P. C. Moyosore, Afodun Adam Ale, B. A. Ekpono, E. U. Awoke, J. N. Ogbu, Patience N. Ukachi, O. U. Orji, O. U. Nweke, P. C. Egwu, C. O. Ekpono, E. U. Ewa, G. O. Igwenyi, I. O. Alum, E. U. Chukwu, D. C. Aja, Lucy Ani, G. O. Offor, C. E. Yakubu, O. E. Maduagwuna, E. Akobi, J. B. Noreen, Sana Awuchi, Chinaza Godswill |
| description | Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to six experimental groups (n = 6), A, B, C, D, E, and F. Group A received 1 mL of olive oil. Groups B and C received 100 mL/kg body weight (BW) of BPA and 7.5 mL/kg BW CMSO, respectively. Rats in groups D, E, and F received preadministered doses of 100 mL/kg BW of BPA, 5 mL/kg BW of BPA, and 2.5 mL/kg BW of CMSO, respectively, followed by 6 weeks of exposure to those doses. Some mitochondrial enzymes, mitochondrial membrane potential (MMP), mitochondria testicular protein, and body weight of rats were determined using standard methods. BPA significantly reduced succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, NADH dehydrogenase, and monoamine oxidase activity. Also, BPA prominently decreased the MMP, mitochondrial testicular protein, and body weight of rats. Interestingly, coadministration of BPA and CMSO restored the dysregulated activities of the enzymes and levels of other biomarkers. We postulated that CMSO may be a promising drug for treating systemic toxicity caused by environmental toxicants such as BPA.
The study examined the effect of Cucumeropsis mannii seed oil (CMSO) on the biochemical toxicity produced by bisphenol A (BPA) in the testicular mitochondria of male albino rats. This study suggests that CMSO could be an effective treatment for systemic toxicity produced by environmental toxins such as BPA. |
| doi_str_mv | 10.1002/fsn3.4379 |
| format | Article |
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The study examined the effect of Cucumeropsis mannii seed oil (CMSO) on the biochemical toxicity produced by bisphenol A (BPA) in the testicular mitochondria of male albino rats. This study suggests that CMSO could be an effective treatment for systemic toxicity produced by environmental toxins such as BPA.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.4379</identifier><identifier>PMID: 39479659</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Amine oxidase (flavin-containing) ; Amino acids ; Animals ; Antioxidants ; Atherosclerosis ; Biochemistry ; Biomarkers ; Bisphenol A ; Body weight ; Cucumeropsis mannii ; Cucumeropsis mannii seed oil ; Dehydrogenase ; Dietary minerals ; Endocrine disruptors ; Enzymes ; Fatty acids ; Infertility ; Isocitrate dehydrogenase ; Laboratories ; Malate dehydrogenase ; Males ; Membrane potential ; Mitochondria ; mitochondrial enzymes ; mitochondrial membrane potential ; NADH dehydrogenase ; Nicotinamide adenine dinucleotide ; nutraceutical ; Oilseeds ; Olive oil ; Original ; Phytochemicals ; Proteins ; Seeds ; Succinate dehydrogenase ; Testes ; Toxicants ; Toxicity</subject><ispartof>Food science & nutrition, 2024-10, Vol.12 (10), p.7854-7863</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3889-123e7ed2f2b804d46b301e3232b69ce6751b412bf773cc0c977b7e843a46f6c43</cites><orcidid>0000-0001-5071-8895 ; 0000-0001-7805-9027 ; 0000-0002-3060-066X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521674/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521674/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39479659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogwoni, H. A.</creatorcontrib><creatorcontrib>Aja, P. M.</creatorcontrib><creatorcontrib>Eze, Ejike Daniel</creatorcontrib><creatorcontrib>Agu, P. C.</creatorcontrib><creatorcontrib>Moyosore, Afodun Adam</creatorcontrib><creatorcontrib>Ale, B. A.</creatorcontrib><creatorcontrib>Ekpono, E. U.</creatorcontrib><creatorcontrib>Awoke, J. N.</creatorcontrib><creatorcontrib>Ogbu, Patience N.</creatorcontrib><creatorcontrib>Ukachi, O. U.</creatorcontrib><creatorcontrib>Orji, O. U.</creatorcontrib><creatorcontrib>Nweke, P. C.</creatorcontrib><creatorcontrib>Egwu, C. O.</creatorcontrib><creatorcontrib>Ekpono, E. U.</creatorcontrib><creatorcontrib>Ewa, G. O.</creatorcontrib><creatorcontrib>Igwenyi, I. O.</creatorcontrib><creatorcontrib>Alum, E. U.</creatorcontrib><creatorcontrib>Chukwu, D. C.</creatorcontrib><creatorcontrib>Aja, Lucy</creatorcontrib><creatorcontrib>Ani, G. O.</creatorcontrib><creatorcontrib>Offor, C. E.</creatorcontrib><creatorcontrib>Yakubu, O. E.</creatorcontrib><creatorcontrib>Maduagwuna, E.</creatorcontrib><creatorcontrib>Akobi, J. B.</creatorcontrib><creatorcontrib>Noreen, Sana</creatorcontrib><creatorcontrib>Awuchi, Chinaza Godswill</creatorcontrib><title>Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A</title><title>Food science & nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to six experimental groups (n = 6), A, B, C, D, E, and F. Group A received 1 mL of olive oil. Groups B and C received 100 mL/kg body weight (BW) of BPA and 7.5 mL/kg BW CMSO, respectively. Rats in groups D, E, and F received preadministered doses of 100 mL/kg BW of BPA, 5 mL/kg BW of BPA, and 2.5 mL/kg BW of CMSO, respectively, followed by 6 weeks of exposure to those doses. Some mitochondrial enzymes, mitochondrial membrane potential (MMP), mitochondria testicular protein, and body weight of rats were determined using standard methods. BPA significantly reduced succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, NADH dehydrogenase, and monoamine oxidase activity. Also, BPA prominently decreased the MMP, mitochondrial testicular protein, and body weight of rats. Interestingly, coadministration of BPA and CMSO restored the dysregulated activities of the enzymes and levels of other biomarkers. We postulated that CMSO may be a promising drug for treating systemic toxicity caused by environmental toxicants such as BPA.
The study examined the effect of Cucumeropsis mannii seed oil (CMSO) on the biochemical toxicity produced by bisphenol A (BPA) in the testicular mitochondria of male albino rats. This study suggests that CMSO could be an effective treatment for systemic toxicity produced by environmental toxins such as BPA.</description><subject>Amine oxidase (flavin-containing)</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Atherosclerosis</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Bisphenol A</subject><subject>Body weight</subject><subject>Cucumeropsis mannii</subject><subject>Cucumeropsis mannii seed oil</subject><subject>Dehydrogenase</subject><subject>Dietary minerals</subject><subject>Endocrine disruptors</subject><subject>Enzymes</subject><subject>Fatty acids</subject><subject>Infertility</subject><subject>Isocitrate dehydrogenase</subject><subject>Laboratories</subject><subject>Malate dehydrogenase</subject><subject>Males</subject><subject>Membrane potential</subject><subject>Mitochondria</subject><subject>mitochondrial enzymes</subject><subject>mitochondrial membrane potential</subject><subject>NADH dehydrogenase</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>nutraceutical</subject><subject>Oilseeds</subject><subject>Olive oil</subject><subject>Original</subject><subject>Phytochemicals</subject><subject>Proteins</subject><subject>Seeds</subject><subject>Succinate dehydrogenase</subject><subject>Testes</subject><subject>Toxicants</subject><subject>Toxicity</subject><issn>2048-7177</issn><issn>2048-7177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1ks1O3DAQgKOqVUGUQ1-gstQLHBbin7WTU4VWpUWi5QA9W7Yz2TVy7NROoOEVeak6XUAUCR_skebz5_FoiuIjLo9wWZLjNnl6xKio3xS7pGTVQmAh3j6Ld4r9lK7LvGqGOSHvix1aM1HzZb1b3K9GM3YQQ59sQp3y3lqUABoUrEMHqx-XF4coQhpC3tCQA2tGpyLq7BDMJvgmWuVQM6V29GawwSekJ9SFJlOD9Ws0bACpnLmxg82K0M5whPWcz8-8qgR_N3X5gvW5LJcdTlsfUFRDQvCnD2m-HJC2qd-ADw6dfCjetcol2H8494pfp1-vVt8X5xffzlYn5wtDq6peYEJBQENaoquSNYxrWmKghBLNawNcLLFmmOhWCGpMaWohtICKUcV4yw2je8WXrbcfdQeNAT9E5WQfbafiJIOy8v-Mtxu5DjcS4yXBXMyGgwdDDL_H3AHZ2WTAOeUhjElSTAhnnFYko59foNdhjD7_b6awYIxgmqnDLWViSLm77VM1uJTzmMh5TOQ8Jpn99Lz8J_JxKDJwvAVurYPpdZM8vfxJ_yn_ApPKzRU</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Ogwoni, H. 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A.</au><au>Aja, P. M.</au><au>Eze, Ejike Daniel</au><au>Agu, P. C.</au><au>Moyosore, Afodun Adam</au><au>Ale, B. A.</au><au>Ekpono, E. U.</au><au>Awoke, J. N.</au><au>Ogbu, Patience N.</au><au>Ukachi, O. U.</au><au>Orji, O. U.</au><au>Nweke, P. C.</au><au>Egwu, C. O.</au><au>Ekpono, E. U.</au><au>Ewa, G. O.</au><au>Igwenyi, I. O.</au><au>Alum, E. U.</au><au>Chukwu, D. C.</au><au>Aja, Lucy</au><au>Ani, G. O.</au><au>Offor, C. E.</au><au>Yakubu, O. E.</au><au>Maduagwuna, E.</au><au>Akobi, J. B.</au><au>Noreen, Sana</au><au>Awuchi, Chinaza Godswill</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A</atitle><jtitle>Food science & nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2024-10</date><risdate>2024</risdate><volume>12</volume><issue>10</issue><spage>7854</spage><epage>7863</epage><pages>7854-7863</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to six experimental groups (n = 6), A, B, C, D, E, and F. Group A received 1 mL of olive oil. Groups B and C received 100 mL/kg body weight (BW) of BPA and 7.5 mL/kg BW CMSO, respectively. Rats in groups D, E, and F received preadministered doses of 100 mL/kg BW of BPA, 5 mL/kg BW of BPA, and 2.5 mL/kg BW of CMSO, respectively, followed by 6 weeks of exposure to those doses. Some mitochondrial enzymes, mitochondrial membrane potential (MMP), mitochondria testicular protein, and body weight of rats were determined using standard methods. BPA significantly reduced succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, NADH dehydrogenase, and monoamine oxidase activity. Also, BPA prominently decreased the MMP, mitochondrial testicular protein, and body weight of rats. Interestingly, coadministration of BPA and CMSO restored the dysregulated activities of the enzymes and levels of other biomarkers. We postulated that CMSO may be a promising drug for treating systemic toxicity caused by environmental toxicants such as BPA.
The study examined the effect of Cucumeropsis mannii seed oil (CMSO) on the biochemical toxicity produced by bisphenol A (BPA) in the testicular mitochondria of male albino rats. This study suggests that CMSO could be an effective treatment for systemic toxicity produced by environmental toxins such as BPA.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>39479659</pmid><doi>10.1002/fsn3.4379</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5071-8895</orcidid><orcidid>https://orcid.org/0000-0001-7805-9027</orcidid><orcidid>https://orcid.org/0000-0002-3060-066X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2048-7177 |
| ispartof | Food science & nutrition, 2024-10, Vol.12 (10), p.7854-7863 |
| issn | 2048-7177 2048-7177 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11521674 |
| source | Wiley-Blackwell Open Access Collection; Wiley Online Library All Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Amine oxidase (flavin-containing) Amino acids Animals Antioxidants Atherosclerosis Biochemistry Biomarkers Bisphenol A Body weight Cucumeropsis mannii Cucumeropsis mannii seed oil Dehydrogenase Dietary minerals Endocrine disruptors Enzymes Fatty acids Infertility Isocitrate dehydrogenase Laboratories Malate dehydrogenase Males Membrane potential Mitochondria mitochondrial enzymes mitochondrial membrane potential NADH dehydrogenase Nicotinamide adenine dinucleotide nutraceutical Oilseeds Olive oil Original Phytochemicals Proteins Seeds Succinate dehydrogenase Testes Toxicants Toxicity |
| title | Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T21%3A00%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cucumeropsis%20mannii%20seed%20oil%20(CMSO)%20restores%20testicular%20mitochondrial%20dysfunctions%20by%20modulating%20the%20activities%20of%20dysregulated%20testicular%20mitochondrial%20enzymes%20in%20male%20albino%20rats%20exposed%20to%20bisphenol%20A&rft.jtitle=Food%20science%20&%20nutrition&rft.au=Ogwoni,%20H.%20A.&rft.date=2024-10&rft.volume=12&rft.issue=10&rft.spage=7854&rft.epage=7863&rft.pages=7854-7863&rft.issn=2048-7177&rft.eissn=2048-7177&rft_id=info:doi/10.1002/fsn3.4379&rft_dat=%3Cproquest_pubme%3E3121744213%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3121744213&rft_id=info:pmid/39479659&rfr_iscdi=true |