Ferroptosis contributes to diabetes-induced visual pathway neuronal damage via iron accumulation and GPX4 inactivation

The damage of the diabetic visual pathway is one of the main causes of blindness in diabetic patients. Visual pathways include anatomic parts from the retina to the occipital lobe. This study investigated the involvement of ferroptosis, a planned cell death brought on by the buildup of free iron in...

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Veröffentlicht in:	Metabolic brain disease 2024-10, Vol.39 (7), p.1459-1468
Hauptverfasser:	Wang, Bowen, Jin, Ying, Ouyang, Xuan, Zhu, Ru, Wang, Xinghua, Li, Shuang, Jiang, Fagang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Cell death Damage Diabetes Diabetes mellitus Ferroptosis Glial fibrillary acidic protein Glutathione Glutathione peroxidase Immunofluorescence Inactivation Iron Metabolic Diseases Nerves Neurology Neuronal-glial interactions Neurosciences Occipital lobe Oncology Optic nerve Peroxidase Retina Streptozocin Transmission electron microscopy Vacuoles Visual observation Visual pathways Western blotting
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