Progress in the Stereoselective Synthesis Methods of Pyrrolidine-Containing Drugs and Their Precursors
The presented review systematizes and summarizes the data on the synthesis of pyrrolidine derivatives, which are precursors for obtaining drugs. Based on the analysis of published data, the most promising directions in the synthesis of biologically active compounds containing a pyrrolidine ring are...
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| Veröffentlicht in: | International journal of molecular sciences 2024-10, Vol.25 (20), p.11158 |
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| container_title | International journal of molecular sciences |
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| creator | Smolobochkin, Andrey Gazizov, Almir Appazov, Nurbol Sinyashin, Oleg Burilov, Alexander |
| description | The presented review systematizes and summarizes the data on the synthesis of pyrrolidine derivatives, which are precursors for obtaining drugs. Based on the analysis of published data, the most promising directions in the synthesis of biologically active compounds containing a pyrrolidine ring are identified. Stereoselective synthesis methods are classified based on the source of the pyrrolidine ring. The first group includes methods that use a pyrrolidine ring as the starting compound. The second group combines stereoselective methods of cyclization of acyclic starting compounds, which lead to optically pure pyrrolidine derivatives. |
| doi_str_mv | 10.3390/ijms252011158 |
| format | Article |
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| subjects | Aluminum Amino acids Chemical properties Chemical research Chemical synthesis Chemistry Techniques, Synthetic - methods Chloride Cyclization Drugs Epilepsy Health aspects Hepatitis Heterocyclic compounds Hormones Methods Oxidation Peptides Pharmaceutical chemistry Psychotropic drugs Pyrrole Pyrrolidines - chemical synthesis Pyrrolidines - chemistry Review Stereoisomerism |
| title | Progress in the Stereoselective Synthesis Methods of Pyrrolidine-Containing Drugs and Their Precursors |
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