Single-Nuclei Transcriptome Profiling Reveals Intra-Tumoral Heterogeneity and Characterizes Tumor Microenvironment Architecture in a Murine Melanoma Model

Malignant melanoma is an aggressive cancer, with a high risk of metastasis and mortality rates, characterized by cancer cell heterogeneity and complex tumor microenvironment (TME). Single cell biology is an ideal and powerful tool to address these features at a molecular level. However, this approac...

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Veröffentlicht in:	International journal of molecular sciences 2024-10, Vol.25 (20), p.11228
Hauptverfasser:	Parab, Sushant, Sarlo, Valery, Capellero, Sonia, Palmiotto, Luca, Bartolini, Alice, Cantarella, Daniela, Turi, Marcello, Gullà, Annamaria, Grassi, Elena, Lazzari, Chiara, Rubatto, Marco, Gregorc, Vanesa, Carnevale-Schianca, Fabrizio, Olivero, Martina, Bussolino, Federico, Comunanza, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Automation Biological markers Biomarkers Cancer Care and treatment Cell Line, Tumor Cells Development and progression Diagnosis Disease Models, Animal Fibroblasts Flow cytometry Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Genes Genetic aspects Genetic Heterogeneity Genomics Immunotherapy Investigations Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Melanoma, Experimental - genetics Melanoma, Experimental - pathology Metastasis Mice Mice, Inbred C57BL Mutation Patient outcomes Proto-Oncogene Proteins B-raf - genetics RNA sequencing Single-Cell Analysis - methods Skin Neoplasms - genetics Skin Neoplasms - pathology Transcriptome Tumor Microenvironment - genetics Tumors
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