Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying Its Stability In Vivo

What happens to macromolecules in vivo? What drives the structure–activity relationship and in vivo stability for antibody-drug conjugates (ADCs)? These interrelated questions are increasingly relevant due to the re-emerging importance of ADCs as an impactful therapeutic modality and the gaps that e...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Analytical chemistry (Washington) 2024-10, Vol.96 (42), p.16525-16533
Hauptverfasser:	Huang, Yue, Tan, Hui Yin, Yuan, Jiaqi, Mu, Ruipeng, Yang, Junyan, Ball, Kathryn, Vijayakrishnan, Balakumar, Masterson, Luke, Kinneer, Krista, Luheshi, Nadia, Liang, Meina, Rosenbaum, Anton I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biotransformation Conjugates Conjugation DNA topoisomerase Drug development Drug metabolism In vivo methods and tests Macromolecules Malignancy Structural analysis Structural stability Succinimide
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!