Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study
Background/Purpose Extranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2024-08, Vol.31 (8), p.569-580 |
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| container_title | Journal of hepato-biliary-pancreatic sciences |
| container_volume | 31 |
| creator | Sung, Min Kyu Chun, Jihyun Park, Yejong Kwak, Bong Jun Lee, Woohyung Song, Ki Byung Lee, Jae Hoon Kim, Song Cheol Hong, Seung Mo Hwang, Dae Wook |
| description | Background/Purpose
Extranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC prognosis.
Methods
We analyzed data collected from electronic medical records of patients with PBTC who underwent distal pancreatectomy at a single center between January 2011 and December 2015. The patients were categorized based on ENE presence and prognostic implications were evaluated using Kaplan–Meier survival curves and Cox proportional hazards model.
Results
PBTC cases involving lymph node (LN) metastasis and ENE exhibited significantly lower disease‐free (DFS) and overall survival (OS) rates compared to cases without LN metastasis or ENE (median DFS; N0, 23 months; LN+/ENE−, 10 months; LN+/ENE+, 5 months; p |
| doi_str_mv | 10.1002/jhbp.12008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11503450</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3096434797</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3388-1a4e329c3f5ba2b96da3ee8e30fac71eafde16a9c5f69908842c64d23db604813</originalsourceid><addsrcrecordid>eNp9kUFrGzEQhUVpaILjS39AEeRSAk6k1Vor5RIck8QpgfbQnoVWOxvLrKWtpHXjf18lTkyaQwWDxMzH440eQp8pOaOEFOerZd2f0YIQ8QEdUcHFhEtRfNy_q_IQjWNckXwYZZKRT-iQCVGxqhBHqL1-TEE73-gOw2MCF6132Lq2G8AZiLgP_sH5aGNu4l47E0Ana3Dtm-150rbDJjchXOAZDpCCjz2YZDeAjV_6kHBMQ7M9Rget7iKMX-4R-nVz_XO-mNx_v72bz-4nhmVPE6pLYIU0rJ3WuqglbzQDEMBIq01FQbcNUK6lmbZcSiJEWRheNgVrak5KQdkIXe50-6FeQ2PA5e061Qe71mGrvLbq34mzS_XgN4rSKWFlrhH6-qIQ_O8BYlJrGw10nXbgh6gY4aKaCkFYRk_eoSs_BJf3y5TkJSsrWWXqdEeZ_DcxQLt3Q4l6ilA9RaieI8zwl7f-9-hrYBmgO-CP7WD7Hyn1bXH1Yyf6F70kqP0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3096434797</pqid></control><display><type>article</type><title>Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Sung, Min Kyu ; Chun, Jihyun ; Park, Yejong ; Kwak, Bong Jun ; Lee, Woohyung ; Song, Ki Byung ; Lee, Jae Hoon ; Kim, Song Cheol ; Hong, Seung Mo ; Hwang, Dae Wook</creator><creatorcontrib>Sung, Min Kyu ; Chun, Jihyun ; Park, Yejong ; Kwak, Bong Jun ; Lee, Woohyung ; Song, Ki Byung ; Lee, Jae Hoon ; Kim, Song Cheol ; Hong, Seung Mo ; Hwang, Dae Wook</creatorcontrib><description>Background/Purpose
Extranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC prognosis.
Methods
We analyzed data collected from electronic medical records of patients with PBTC who underwent distal pancreatectomy at a single center between January 2011 and December 2015. The patients were categorized based on ENE presence and prognostic implications were evaluated using Kaplan–Meier survival curves and Cox proportional hazards model.
Results
PBTC cases involving lymph node (LN) metastasis and ENE exhibited significantly lower disease‐free (DFS) and overall survival (OS) rates compared to cases without LN metastasis or ENE (median DFS; N0, 23 months; LN+/ENE−, 10 months; LN+/ENE+, 5 months; p < .001). No statistically significant difference was observed in DFS and OS rates between patients with N1/N2 in the group without ENE and those with ENE+. Multivariate analysis confirmed ENE as a significant adverse prognostic factor.
Conclusions
ENE significantly predicts poor prognosis in PBTC, particularly in cases with nodal metastasis. The current cancer staging system for PBTC should incorporate ENE status. Moreover, different staging systems should be considered for PHC and PBTC.
Sung and colleagues identified extranodal extension as a significant adverse prognostic factor in patients with pancreatic body/tail cancer, concluding that extranodal extension should be incorporated into the current staging system. Additionally, the differences observed in subgroup analysis between pancreatic head and body/tail cancer suggest the necessity of separate staging systems.</description><identifier>ISSN: 1868-6974</identifier><identifier>ISSN: 1868-6982</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.12008</identifier><identifier>PMID: 38873728</identifier><language>eng</language><publisher>Japan: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Cancer ; Disease-Free Survival ; extranodal extension ; Extranodal Extension - pathology ; Female ; Humans ; Lymphatic Metastasis ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Neoplasm Staging ; Original ; Pancreatectomy ; pancreatic cancer ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Prognosis ; Retrospective Studies ; survival ; Survival Rate ; TNM staging system</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2024-08, Vol.31 (8), p.569-580</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato‐Biliary‐Pancreatic Surgery.</rights><rights>2024 The Author(s). Journal of Hepato‐Biliary‐Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato‐Biliary‐Pancreatic Surgery.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3388-1a4e329c3f5ba2b96da3ee8e30fac71eafde16a9c5f69908842c64d23db604813</cites><orcidid>0000-0002-8119-6943 ; 0000-0001-5422-5481 ; 0000-0002-1749-038X ; 0000-0001-8532-9531</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.12008$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.12008$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38873728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sung, Min Kyu</creatorcontrib><creatorcontrib>Chun, Jihyun</creatorcontrib><creatorcontrib>Park, Yejong</creatorcontrib><creatorcontrib>Kwak, Bong Jun</creatorcontrib><creatorcontrib>Lee, Woohyung</creatorcontrib><creatorcontrib>Song, Ki Byung</creatorcontrib><creatorcontrib>Lee, Jae Hoon</creatorcontrib><creatorcontrib>Kim, Song Cheol</creatorcontrib><creatorcontrib>Hong, Seung Mo</creatorcontrib><creatorcontrib>Hwang, Dae Wook</creatorcontrib><title>Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background/Purpose
Extranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC prognosis.
Methods
We analyzed data collected from electronic medical records of patients with PBTC who underwent distal pancreatectomy at a single center between January 2011 and December 2015. The patients were categorized based on ENE presence and prognostic implications were evaluated using Kaplan–Meier survival curves and Cox proportional hazards model.
Results
PBTC cases involving lymph node (LN) metastasis and ENE exhibited significantly lower disease‐free (DFS) and overall survival (OS) rates compared to cases without LN metastasis or ENE (median DFS; N0, 23 months; LN+/ENE−, 10 months; LN+/ENE+, 5 months; p < .001). No statistically significant difference was observed in DFS and OS rates between patients with N1/N2 in the group without ENE and those with ENE+. Multivariate analysis confirmed ENE as a significant adverse prognostic factor.
Conclusions
ENE significantly predicts poor prognosis in PBTC, particularly in cases with nodal metastasis. The current cancer staging system for PBTC should incorporate ENE status. Moreover, different staging systems should be considered for PHC and PBTC.
Sung and colleagues identified extranodal extension as a significant adverse prognostic factor in patients with pancreatic body/tail cancer, concluding that extranodal extension should be incorporated into the current staging system. Additionally, the differences observed in subgroup analysis between pancreatic head and body/tail cancer suggest the necessity of separate staging systems.</description><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Disease-Free Survival</subject><subject>extranodal extension</subject><subject>Extranodal Extension - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Original</subject><subject>Pancreatectomy</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>survival</subject><subject>Survival Rate</subject><subject>TNM staging system</subject><issn>1868-6974</issn><issn>1868-6982</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUFrGzEQhUVpaILjS39AEeRSAk6k1Vor5RIck8QpgfbQnoVWOxvLrKWtpHXjf18lTkyaQwWDxMzH440eQp8pOaOEFOerZd2f0YIQ8QEdUcHFhEtRfNy_q_IQjWNckXwYZZKRT-iQCVGxqhBHqL1-TEE73-gOw2MCF6132Lq2G8AZiLgP_sH5aGNu4l47E0Ana3Dtm-150rbDJjchXOAZDpCCjz2YZDeAjV_6kHBMQ7M9Rget7iKMX-4R-nVz_XO-mNx_v72bz-4nhmVPE6pLYIU0rJ3WuqglbzQDEMBIq01FQbcNUK6lmbZcSiJEWRheNgVrak5KQdkIXe50-6FeQ2PA5e061Qe71mGrvLbq34mzS_XgN4rSKWFlrhH6-qIQ_O8BYlJrGw10nXbgh6gY4aKaCkFYRk_eoSs_BJf3y5TkJSsrWWXqdEeZ_DcxQLt3Q4l6ilA9RaieI8zwl7f-9-hrYBmgO-CP7WD7Hyn1bXH1Yyf6F70kqP0</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Sung, Min Kyu</creator><creator>Chun, Jihyun</creator><creator>Park, Yejong</creator><creator>Kwak, Bong Jun</creator><creator>Lee, Woohyung</creator><creator>Song, Ki Byung</creator><creator>Lee, Jae Hoon</creator><creator>Kim, Song Cheol</creator><creator>Hong, Seung Mo</creator><creator>Hwang, Dae Wook</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8119-6943</orcidid><orcidid>https://orcid.org/0000-0001-5422-5481</orcidid><orcidid>https://orcid.org/0000-0002-1749-038X</orcidid><orcidid>https://orcid.org/0000-0001-8532-9531</orcidid></search><sort><creationdate>202408</creationdate><title>Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study</title><author>Sung, Min Kyu ; Chun, Jihyun ; Park, Yejong ; Kwak, Bong Jun ; Lee, Woohyung ; Song, Ki Byung ; Lee, Jae Hoon ; Kim, Song Cheol ; Hong, Seung Mo ; Hwang, Dae Wook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3388-1a4e329c3f5ba2b96da3ee8e30fac71eafde16a9c5f69908842c64d23db604813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Disease-Free Survival</topic><topic>extranodal extension</topic><topic>Extranodal Extension - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Original</topic><topic>Pancreatectomy</topic><topic>pancreatic cancer</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>survival</topic><topic>Survival Rate</topic><topic>TNM staging system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sung, Min Kyu</creatorcontrib><creatorcontrib>Chun, Jihyun</creatorcontrib><creatorcontrib>Park, Yejong</creatorcontrib><creatorcontrib>Kwak, Bong Jun</creatorcontrib><creatorcontrib>Lee, Woohyung</creatorcontrib><creatorcontrib>Song, Ki Byung</creatorcontrib><creatorcontrib>Lee, Jae Hoon</creatorcontrib><creatorcontrib>Kim, Song Cheol</creatorcontrib><creatorcontrib>Hong, Seung Mo</creatorcontrib><creatorcontrib>Hwang, Dae Wook</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sung, Min Kyu</au><au>Chun, Jihyun</au><au>Park, Yejong</au><au>Kwak, Bong Jun</au><au>Lee, Woohyung</au><au>Song, Ki Byung</au><au>Lee, Jae Hoon</au><au>Kim, Song Cheol</au><au>Hong, Seung Mo</au><au>Hwang, Dae Wook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2024-08</date><risdate>2024</risdate><volume>31</volume><issue>8</issue><spage>569</spage><epage>580</epage><pages>569-580</pages><issn>1868-6974</issn><issn>1868-6982</issn><eissn>1868-6982</eissn><abstract>Background/Purpose
Extranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC prognosis.
Methods
We analyzed data collected from electronic medical records of patients with PBTC who underwent distal pancreatectomy at a single center between January 2011 and December 2015. The patients were categorized based on ENE presence and prognostic implications were evaluated using Kaplan–Meier survival curves and Cox proportional hazards model.
Results
PBTC cases involving lymph node (LN) metastasis and ENE exhibited significantly lower disease‐free (DFS) and overall survival (OS) rates compared to cases without LN metastasis or ENE (median DFS; N0, 23 months; LN+/ENE−, 10 months; LN+/ENE+, 5 months; p < .001). No statistically significant difference was observed in DFS and OS rates between patients with N1/N2 in the group without ENE and those with ENE+. Multivariate analysis confirmed ENE as a significant adverse prognostic factor.
Conclusions
ENE significantly predicts poor prognosis in PBTC, particularly in cases with nodal metastasis. The current cancer staging system for PBTC should incorporate ENE status. Moreover, different staging systems should be considered for PHC and PBTC.
Sung and colleagues identified extranodal extension as a significant adverse prognostic factor in patients with pancreatic body/tail cancer, concluding that extranodal extension should be incorporated into the current staging system. Additionally, the differences observed in subgroup analysis between pancreatic head and body/tail cancer suggest the necessity of separate staging systems.</abstract><cop>Japan</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38873728</pmid><doi>10.1002/jhbp.12008</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8119-6943</orcidid><orcidid>https://orcid.org/0000-0001-5422-5481</orcidid><orcidid>https://orcid.org/0000-0002-1749-038X</orcidid><orcidid>https://orcid.org/0000-0001-8532-9531</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of hepato-biliary-pancreatic sciences, 2024-08, Vol.31 (8), p.569-580 |
| issn | 1868-6974 1868-6982 1868-6982 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Cancer Disease-Free Survival extranodal extension Extranodal Extension - pathology Female Humans Lymphatic Metastasis Male Medical prognosis Metastasis Middle Aged Neoplasm Staging Original Pancreatectomy pancreatic cancer Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Prognosis Retrospective Studies survival Survival Rate TNM staging system |
| title | Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study |
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