Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets
High‐throughput sequencing has sparked increased research interest in RNA modifications, particularly tRNA methylation, and its connection to various diseases. However, the precise mechanisms underpinning the development of these diseases remain largely elusive. This review sheds light on the roles...
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| Veröffentlicht in: | Cell proliferation 2024-09, Vol.57 (9), p.e13692-n/a |
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| description | High‐throughput sequencing has sparked increased research interest in RNA modifications, particularly tRNA methylation, and its connection to various diseases. However, the precise mechanisms underpinning the development of these diseases remain largely elusive. This review sheds light on the roles of several tRNA methylations (m1A, m3C, m5C, m1G, m2G, m7G, m5U, and Nm) in diverse biological functions, including metabolic processing, stability, protein interactions, and mitochondrial activities. It further outlines diseases linked to aberrant tRNA modifications, related enzymes, and potential underlying mechanisms. Moreover, disruptions in tRNA regulation and abnormalities in tRNA‐derived small RNAs (tsRNAs) contribute to disease pathogenesis, highlighting their potential as biomarkers for disease diagnosis. The review also delves into the exploration of drugs development targeting tRNA methylation enzymes, emphasizing the therapeutic prospects of modulating these processes. Continued research is imperative for a comprehensive comprehension and integration of these molecular mechanisms in disease diagnosis and treatment.
Dysregulation of tRNA methylation modifications and their associated enzymes has been implicated in a spectrum of diseases, including cancer and neurological disorders. Further exploration is warranted to fully elucidate the diagnostic and therapeutic potential of tRNA methylations in human diseases. |
| doi_str_mv | 10.1111/cpr.13692 |
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Dysregulation of tRNA methylation modifications and their associated enzymes has been implicated in a spectrum of diseases, including cancer and neurological disorders. Further exploration is warranted to fully elucidate the diagnostic and therapeutic potential of tRNA methylations in human diseases.</description><identifier>ISSN: 0960-7722</identifier><identifier>ISSN: 1365-2184</identifier><identifier>EISSN: 1365-2184</identifier><identifier>DOI: 10.1111/cpr.13692</identifier><identifier>PMID: 38943267</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Abnormalities ; Apoptosis ; Biomarkers ; Cell cycle ; Diagnosis ; DNA methylation ; Drug delivery ; Drug development ; Enzymes ; Gene sequencing ; Lung cancer ; Medical prognosis ; Metabolism ; Metabolites ; Methylation ; Molecular modelling ; Mutation ; Neurological disorders ; Oxidative stress ; Pathogenesis ; Protein interaction ; Proteins ; Review ; Ribonucleic acid ; RNA ; Therapeutic targets ; Transfer RNA ; tRNA ; Tumorigenesis</subject><ispartof>Cell proliferation, 2024-09, Vol.57 (9), p.e13692-n/a</ispartof><rights>2024 The Author(s). published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3342-a55fd6c3ead32752c5dc475f39752d8636673ab230c5a7c623b6be0d3e6aeec63</cites><orcidid>0009-0004-9435-8843</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503269/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503269/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38943267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Zhijing</creatorcontrib><creatorcontrib>Zhou, Ruixin</creatorcontrib><creatorcontrib>Li, Baizao</creatorcontrib><creatorcontrib>Cao, Mingyu</creatorcontrib><creatorcontrib>Wang, Wenlong</creatorcontrib><creatorcontrib>Li, Xinying</creatorcontrib><title>Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets</title><title>Cell proliferation</title><addtitle>Cell Prolif</addtitle><description>High‐throughput sequencing has sparked increased research interest in RNA modifications, particularly tRNA methylation, and its connection to various diseases. However, the precise mechanisms underpinning the development of these diseases remain largely elusive. This review sheds light on the roles of several tRNA methylations (m1A, m3C, m5C, m1G, m2G, m7G, m5U, and Nm) in diverse biological functions, including metabolic processing, stability, protein interactions, and mitochondrial activities. It further outlines diseases linked to aberrant tRNA modifications, related enzymes, and potential underlying mechanisms. Moreover, disruptions in tRNA regulation and abnormalities in tRNA‐derived small RNAs (tsRNAs) contribute to disease pathogenesis, highlighting their potential as biomarkers for disease diagnosis. The review also delves into the exploration of drugs development targeting tRNA methylation enzymes, emphasizing the therapeutic prospects of modulating these processes. Continued research is imperative for a comprehensive comprehension and integration of these molecular mechanisms in disease diagnosis and treatment.
Dysregulation of tRNA methylation modifications and their associated enzymes has been implicated in a spectrum of diseases, including cancer and neurological disorders. Further exploration is warranted to fully elucidate the diagnostic and therapeutic potential of tRNA methylations in human diseases.</description><subject>Abnormalities</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Cell cycle</subject><subject>Diagnosis</subject><subject>DNA methylation</subject><subject>Drug delivery</subject><subject>Drug development</subject><subject>Enzymes</subject><subject>Gene sequencing</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Methylation</subject><subject>Molecular modelling</subject><subject>Mutation</subject><subject>Neurological disorders</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Protein interaction</subject><subject>Proteins</subject><subject>Review</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Therapeutic targets</subject><subject>Transfer RNA</subject><subject>tRNA</subject><subject>Tumorigenesis</subject><issn>0960-7722</issn><issn>1365-2184</issn><issn>1365-2184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1vEzEQhi0EoqFw4A8gS1zoYVvbE9u7XFAVlQ-pfKiCs-XYs42rzXpre0H595ikVIDEXEbjefTqHb-EPOfslNc6c1M65aA68YAsapeN4O3yIVmwTrFGayGOyJOcbxjjwLV6TI6g7ZYglF6Q8SOWzW6wJcSRbqMPfXD7IdMw0nL16Zza0VObc3TBFvTUhxyTx5Rf09WcEo6FJsxok9vs0SmW-hbsQMsGk51wLsHRYtM1lvyUPOrtkPHZXT8m395efF29by4_v_uwOr9sHMBSNFbK3isHaD0ILYWT3i217KGrg28VKKXBrgUwJ612SsBarZF5QGURnYJj8uagO83rLXpXHSU7mCmFrU07E20wf2_GsDHX8bvhXLL6M11VeHWnkOLtjLmYbcgOh8GOGOdsgGnQHETLKvryH_Qmzmms9xnggoHkHNpKnRwol2LOCft7N5yZXzGaGqPZx1jZF3_avyd_51aBswPwIwy4-7-SWX25Okj-BJK4qWw</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Wu, Zhijing</creator><creator>Zhou, Ruixin</creator><creator>Li, Baizao</creator><creator>Cao, Mingyu</creator><creator>Wang, Wenlong</creator><creator>Li, Xinying</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0004-9435-8843</orcidid></search><sort><creationdate>202409</creationdate><title>Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets</title><author>Wu, Zhijing ; Zhou, Ruixin ; Li, Baizao ; Cao, Mingyu ; Wang, Wenlong ; Li, Xinying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3342-a55fd6c3ead32752c5dc475f39752d8636673ab230c5a7c623b6be0d3e6aeec63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abnormalities</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Cell cycle</topic><topic>Diagnosis</topic><topic>DNA methylation</topic><topic>Drug delivery</topic><topic>Drug development</topic><topic>Enzymes</topic><topic>Gene sequencing</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Methylation</topic><topic>Molecular modelling</topic><topic>Mutation</topic><topic>Neurological disorders</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Protein interaction</topic><topic>Proteins</topic><topic>Review</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Therapeutic targets</topic><topic>Transfer RNA</topic><topic>tRNA</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Zhijing</creatorcontrib><creatorcontrib>Zhou, Ruixin</creatorcontrib><creatorcontrib>Li, Baizao</creatorcontrib><creatorcontrib>Cao, Mingyu</creatorcontrib><creatorcontrib>Wang, Wenlong</creatorcontrib><creatorcontrib>Li, Xinying</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell proliferation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Zhijing</au><au>Zhou, Ruixin</au><au>Li, Baizao</au><au>Cao, Mingyu</au><au>Wang, Wenlong</au><au>Li, Xinying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets</atitle><jtitle>Cell proliferation</jtitle><addtitle>Cell Prolif</addtitle><date>2024-09</date><risdate>2024</risdate><volume>57</volume><issue>9</issue><spage>e13692</spage><epage>n/a</epage><pages>e13692-n/a</pages><issn>0960-7722</issn><issn>1365-2184</issn><eissn>1365-2184</eissn><abstract>High‐throughput sequencing has sparked increased research interest in RNA modifications, particularly tRNA methylation, and its connection to various diseases. However, the precise mechanisms underpinning the development of these diseases remain largely elusive. This review sheds light on the roles of several tRNA methylations (m1A, m3C, m5C, m1G, m2G, m7G, m5U, and Nm) in diverse biological functions, including metabolic processing, stability, protein interactions, and mitochondrial activities. It further outlines diseases linked to aberrant tRNA modifications, related enzymes, and potential underlying mechanisms. Moreover, disruptions in tRNA regulation and abnormalities in tRNA‐derived small RNAs (tsRNAs) contribute to disease pathogenesis, highlighting their potential as biomarkers for disease diagnosis. The review also delves into the exploration of drugs development targeting tRNA methylation enzymes, emphasizing the therapeutic prospects of modulating these processes. Continued research is imperative for a comprehensive comprehension and integration of these molecular mechanisms in disease diagnosis and treatment.
Dysregulation of tRNA methylation modifications and their associated enzymes has been implicated in a spectrum of diseases, including cancer and neurological disorders. Further exploration is warranted to fully elucidate the diagnostic and therapeutic potential of tRNA methylations in human diseases.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38943267</pmid><doi>10.1111/cpr.13692</doi><tpages>22</tpages><orcidid>https://orcid.org/0009-0004-9435-8843</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell proliferation, 2024-09, Vol.57 (9), p.e13692-n/a |
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| subjects | Abnormalities Apoptosis Biomarkers Cell cycle Diagnosis DNA methylation Drug delivery Drug development Enzymes Gene sequencing Lung cancer Medical prognosis Metabolism Metabolites Methylation Molecular modelling Mutation Neurological disorders Oxidative stress Pathogenesis Protein interaction Proteins Review Ribonucleic acid RNA Therapeutic targets Transfer RNA tRNA Tumorigenesis |
| title | Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets |
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