Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases

The phosphatase activities of type 2A, type 1 and type 2C protein phosphatase preparations were measured against p-nitrophenyl phosphate (pNPP), a commonly used substrate for alkaline phosphatases. Of the three types of phosphatase examined, the type 2A phosphatase exhibited an especially high pNPP...

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Veröffentlicht in:	Biochemical journal 1991-04, Vol.275 (1), p.233-239
Hauptverfasser:	TAKAI, A, MIESKES, G
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitrophenylphosphatase - antagonists & inhibitors Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Dose-Response Relationship, Drug Enzymes and enzyme inhibitors Ethers, Cyclic - administration & dosage Ethers, Cyclic - pharmacology Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Hydrolases Kinetics Magnesium - pharmacology Nitrophenols - metabolism Okadaic Acid Organophosphorus Compounds - metabolism Phosphoprotein Phosphatases - antagonists & inhibitors Protein Phosphatase 1 Proteins - pharmacology Rabbits skeletal muscle
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