Detection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis

Background Within endemic regions in southern and eastern Germany, Borna disease virus 1 (BoDV-1) causes rare zoonotic spill-over infections in humans, leading to encephalitis with a high case-fatality risk. So far, intra-vitam diagnosis has mainly been based on RT-qPCR from cerebrospinal fluid (CSF...

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Veröffentlicht in:	Infection 2024-10, Vol.52 (5), p.1663-1670
Hauptverfasser:	Bauswein, Markus, Eid, Ehab, Eidenschink, Lisa, Schmidt, Barbara, Gessner, André, Tappe, Dennis, Cadar, Dániel, Böhmer, Merle M., Jockel, Laura, van Wickeren, Nora, Garibashvili, Tamara, Wiesinger, Isabel, Wendl, Christina, Heckmann, Josef G., Angstwurm, Klemens, Freyer, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Adult Borna disease Borna Disease - diagnosis Borna Disease - immunology Borna disease virus - immunology Borna virus Case Report Cerebrospinal fluid Diagnosis Early Diagnosis Encephalitis Encephalitis, Viral - diagnosis Encephalitis, Viral - immunology Encephalitis, Viral - virology Enzyme-linked immunosorbent assay Enzyme-Linked Immunospot Assay - methods Family Medicine Fatal Outcome General Practice Germany Health risks Humans Immune adsorption Immunoglobulin G Infectious Diseases Internal Medicine Lymphocytes Lymphocytes T Male Mechanical properties Mechanical ventilation Medical diagnosis Medicine Medicine & Public Health Middle Aged Peripheral blood Seroconversion Serology T-Lymphocytes - immunology Viruses Zoonoses
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