Selection for Late Reproduction Leads to Loss of Complex I Mitochondrial Capacity and Associated Increased Longevity in Seed Beetles

Abstract Mitochondria play a key role in aging. Here, we measured integrated mitochondrial functions in experimentally evolved lines of the seed beetle Acanthoscelides obtectus that were selected for early (E) or late (L) reproduction for nearly 4 decades. The 2 lines have markedly different lifespa...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2024-11, Vol.79 (11)
Hauptverfasser:	Mast, Heather E, Blier, Pierre U, Ɖorđević, Mirko, Savković, Uroš, Holody, Claudia D, Bourque, Stephane L, Lemieux, Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Coleoptera - physiology Electron Transport Complex I - metabolism Longevity - physiology Mitochondria - metabolism NAD - metabolism Reproduction - physiology Selection, Genetic THE JOURNAL OF GERONTOLOGY: Biological Sciences
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