Synthesis of Novel Plant-Derived Encapsulated Radiolabeled Compounds for the Diagnosis of Parkinson’s Disease and the Evaluation of Biological Effects with In Vitro/In Vivo Methods

Parkinson’s disease (PD) is a neurodegenerative disorder that affects millions of individuals globally. It is characterized by the loss of dopaminergic neurons in Substantia Nigra pars compacta (SNc) and striatum. Neuroimaging techniques such as single-photon emission computed tomography (SPECT), po...

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Veröffentlicht in:	Molecular neurobiology 2024-11, Vol.61 (11), p.8851-8871
Hauptverfasser:	Uygur, Emre, Karatay, Kadriye Büşra, Derviş, Emine, Evren, Vedat, Kılçar, Ayfer Yurt, Güldü, Özge Kozguş, Sezgin, Ceren, Çinleti, Burcu Acar, Tekin, Volkan, Muftuler, Fazilet Zumrut Biber
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biodistribution Biological activity Biomedical and Life Sciences Biomedicine Cell Biology Cell culture Cell Line, Tumor Cell lines Chromatography Computed tomography Cytotoxicity Diagnosis Diagnostic agents Dopamine receptors Drug delivery Drug delivery systems High-performance liquid chromatography Humans Levodopa Magnetic resonance imaging Male Mass spectroscopy Mesencephalon Movement disorders Neostriatum Neurobiology Neurodegenerative diseases Neuroimaging Neurology Neurosciences NMR Nuclear magnetic resonance Original Original Article Parkinson Disease - diagnostic imaging Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease PC12 Cells Plants Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Positron emission tomography Rats Rats, Sprague-Dawley Single photon emission computed tomography Statistical analysis Technetium - chemistry Tissue Distribution Tomography
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