The Effect of FTY720 on Sphingolipid Imbalance and Cognitive Decline in Aged EFAD Mice

During Alzheimer's disease (AD) progression, there is a decline in the bioactive sphingolipid sphingosine-1-phosphate (S1P). Previous research showed that FTY720, an S1P mimetic, prevented cognitive decline and reduced ceramide levels in transgenic mice with familial AD carrying the human APOE4...

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Veröffentlicht in:	JAD reports 2024-01, Vol.8 (1), p.1317-1327
Hauptverfasser:	Luo, Qian, Crivelli, Simone M, Zong, Shenghua, Giovagnoni, Caterina, van Kruining, Daan, Mané-Damas, Marina, den Hoedt, Sandra, Berkes, Dusan, De Vries, Helga E, Mulder, Monique T, Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V, Dehairs, Jonas, Losen, Mario, Martinez-Martinez, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Report
Online-Zugang:	Volltext
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