Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal

Abstract Mutations in CDKN1C, encoding p57KIP2, a canonical cell cycle inhibitor, underlie multiple pediatric endocrine syndromes. Despite this central role in disease, little is known about the structure and function of p57KIP2 in the human pancreatic beta cell. Since p57KIP2 is predominantly nucle...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2023-12, Vol.165 (2)
Hauptverfasser:	Choleva, Lauryn, Wang, Peng, Liu, Hongtao, Wood, Olivia, Lambertini, Luca, Scott, Donald K, Karakose, Esra, Stewart, Andrew F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Amino Acid Sequence Amino acids Amino Acids - metabolism Beta cells Cell cycle Cell Nucleus - metabolism Cell size Child Coding Function analysis Humans Immunocytochemistry Insulin-Secreting Cells - metabolism Localization Mutation Nuclear Localization Signals - genetics Nuclear Localization Signals - metabolism Pancreas Pediatrics Phenotypes Polymerase chain reaction Structure-function relationships
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