Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study

Abstract Context Nicotinamide adenine dinucleotide (NAD) levels decline with aging and age-related decline in NAD has been postulated to contribute to age-related diseases. Objective We evaluated the safety and physiologic effects of NAD augmentation by administering its precursor, β-nicotinamide mo...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2023-08, Vol.108 (8), p.1968-1980
Hauptverfasser:	Pencina, Karol Mateusz, Valderrabano, Rodrigo, Wipper, Benjamin, Orkaby, Ariela R, Reid, Kieran F, Storer, Thomas, Lin, Alexander P, Merugumala, Sai, Wilson, Lauren, Latham, Nancy, Ghattas-Puylara, Catherine, Ozimek, Noelle E, Cheng, Ming, Bhargava, Avantika, Memish-Beleva, Yusnie, Lawney, Brian, Lavu, Siva, Swain, Pamela M, Apte, Rajendra S, Sinclair, David A, Livingston, David, Bhasin, Shalender
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Methylisoborneol Aerobic capacity Aged Aging Bioenergetics Blood cholesterol Blood pressure Body Weight Cholesterol Clinical High density lipoprotein Humans Insulin Insulin Resistance Lipids Liver Low density lipoprotein Low density lipoproteins Metabolites Middle age Middle Aged Muscle strength NAD NAD - metabolism NAD - therapeutic use Niacinamide Nicotinamide Mononucleotide - therapeutic use Obesity Older people Overweight Placebos Purines
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