Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells

Intracellular pH (pHi) dynamics regulate normal cell function, and dysregulated pHi dynamics is an emerging hallmark of cancer (constitutively increased pHi) and neurodegeneration (constitutively decreased pHi). However, the molecular mechanisms by which pHi dynamics regulate cell biology are poorly...

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Veröffentlicht in:	The Journal of biological chemistry 2024-10, Vol.300 (10), p.107658, Article 107658
Hauptverfasser:	Romero-Moreno, Ricardo, Czowski, Brandon J., Harris, Lindsey, Kuehn, Jessamine F., White, Katharine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Epithelial Cells - metabolism Glycolysis Humans Hydrogen-Ion Concentration intracellular pH lactate Lactic Acid - metabolism metabolism Notch1 signaling pyruvate Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Signal Transduction Transcription, Genetic
Online-Zugang:	Volltext
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